姓    名: 高瑜
性    别:

 

职    称: 副教授
学    历: 博士
职    务: 福建省青年拔尖人才(创新)
电    话:
专    业: 药剂学
电子邮件: hellogaoyu@126.com
研究方向: 抗肿瘤纳米药物输送系统

教育工作经历
教育背景
☆ 2005.09–2010.07 中国科学院上海药物研究所 博士
专业:药剂学
☆ 2001.09–2005.07 福州大学 学士
专业:制药工程

工作经历
☆ 2010.07–2011.10 中国科学院上海药物研究所 助理研究员
☆ 2013.03–至今 福州大学 副教授
 

教学简介
研究生课程:《现代药剂学》、《新药研发的跨学科知识和技能》
本科生课程:《制药工程导论》、《综合化学实验》、《仪器分析实验》
助教课程:《无机和分析化学》、《仪器分析》


指导本科生科研项目
1、 基于PAMAM树状大分子的肿瘤靶向纳米药物的构建和体外抗肿瘤作用研究,国家基础科学人才培养基金《能力提高》项目(J1103303, J2013-026),2013.06-2015.05
2、 米非司酮壳聚糖微球的制备及体内药动学研究,福建省“大学生创新训练计划”项目(201410386055),2014.05-2015.05
3、 适配体修饰介孔二氧化硅纳米载体的构建及其抗肿瘤转移作用研究,第二十一期本科生科研训练计划项目(21035),2015.06-2016.05
4、 叶酸过表达肿瘤选择性靶向抗癌纳米药物的构建及其体外抗肿瘤活性研究,第二十一期本科生科研训练计划项目(21044),2015.06-2016.05


教研项目
1、福州大学2016年优质研究生课程建设项目;课程名称:新药研发的跨学科知识和技能;课程负责人:贾力,高瑜;2016.04-2018.04
 

科研简介
主要从事创新药物制剂的研究,以提高药物的有效性、降低毒副作用。以上学术成就已在国际重要学术期刊Biotechnol Adv、Drug Discov Today、ACS Nano、Biomaterials、J Controlled Release、Mol Pharmaceutics等上发表论文50余篇,累计影响因子达322分,第一作者以及通讯作者28篇,累计影响因子达163分,论文已被引用1000余次,其中影响因子5.0以上的论文31篇,有19篇论文刊登在《SCI-JCR期刊综合评价主题分区表》一区期刊。相关成果申请专利18件,已授权10件。主持国家自然科学基金面上项目1项,国家自然科学基金青年项目1项,福建省杰出青年科学基金1项,以学术骨干参与两项国家重大科学研究计划项目,参与多项国家自然科学基金面上项目、“973”项目及国家重大新药创制项目等;获福建省第二批“青年拔尖人才(创新)”称号;获中国药学会科技一等奖(2015,排名第五)、上海市药学科技一等奖(2013,排名第五)、上海市药学科技一等奖(2009,排名第三)、中科院百篇优秀博士论文(2011)、中科院院长奖优秀奖(2010)等奖项。先后受邀担任RSC Advances、Analytical Methods、Pharmaceutical Nanotechnology、Current Drug Delivery、Biotechnology and Bioprocess Engineering、Artificial Cells, Nanomedicine and Biotechnology、Acta Pharmacologica Sinica等多个国内外学术期刊的审稿人。 

社会兼职
☆ 美国药学会(AAPS)会员
☆ 福建省药学会药剂专业委员会委员
☆ 中国生物物理学会自由基生物学与自由基医学专业委员会青年委员
☆ 福建省药理学会会员
 

科研项目
1、 智能响应成像型分子靶向/基因治疗联用纳米给药系统一体化诊疗EGFR突变型肺癌研究(81571802),国家基金委自然科学基金面上项目,2016.01-2019.12,项目负责人
2、 还原响应性聚(β-氨基酯)衍生物共输送不同RNA 药物降低肿瘤耐药性研究(81102388),国家基金委青年科学基金项目,2012.01-2014.12,项目负责人
3、 基于循环肿瘤细胞的纳米药物:遏制肿瘤转移的前沿研究(2016J06020),福建省自然科学基金杰青项目,2016.04-2019.04,项目负责人
4、 新型还原响应性阳离子聚合物共输送不同shRNA药物降低肿瘤耐药性研究,中国科学院“优秀博士学位论文、院长奖获得者科研启动专项资金”,2012.01-2013.12,项目负责人
5、 靶向循环肿瘤细胞纳米载体的构建及抗粘附作用研究(2013-XQ-8),福州大学科技发展基金,2013.06-2015.08,项目负责人
6、 多功能介孔二氧化硅纳米载体的构建及其抗肿瘤转移研究(2014-XY-7),福州大学科技发展基金,2014.06-2017.08,项目负责人
7、 靶向循环肿瘤细胞纳米载体的构建及抗肿瘤转移研究(XRC-1323),福州大学人才基金,2013.06-2015.05,项目负责人
8、 基于PAMAM树状大分子的肿瘤靶向纳米药物的构建和体外抗肿瘤作用的研究(J1103303,2013-026),国家基础科学人才培养基金项目,2013.6-2015.5,子课题指导老师
9、 肝癌治疗的新型纳米药物研究 (2012CB932500),国家重大科学研究计划项目,2012.1-2016.8,学术骨干
10、 肺癌在体分子分型的新型纳米分子成像探针基础研究(2015CB931800),国家重大科学研究计划项目,2015.1-2019.8,学术骨干
 

代表性论文
2016年

1. Yu Gao1, Songen Gu1, Yingying Zhang, Xiaodong Xie, Ting Yu, Yusheng Lu, Yewei Zhu, Wenge Chen, Huijuan Zhang, Haiyan Dong, Patrick J. Sinko, and Lee Jia*. The architecture and function of monoclonal antibody-functionalized mesoporous silica nanoparticles loaded with mifepristone: repurposing abortifacient for cancer metastatic chemoprevention. Small. 12 (2016) 2595-2608. (IF = 8.315)
2. Guihua He#, Yu Gao#(co-first author), Cailong Li, Jianlei Wu, Yazhen Li, Longrong Dong, Haijun Chen*. A convenient and efficient approach to synthesize negletein from baicalin. Tetrahedron Letters. 57 (2016) 2001–2005. (IF = 2.347)
3. Xiaodong Xie, Fengqiao Li, Huijuan Zhang, Yusheng Lu, Shu Lian, Hang Lin, Yu Gao*, and Lee Jia*. EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery. Eur. J. Pharm. Sci. 83 (2016) 28-35. (IF = 3.773)
4. Haiyan Dong#, Yu Gao# (co-first author), Patrick Sinko, Zaisheng Wu, Jianguo Xu, Lee Jia*. The nanotechnology race between China and the United States. Nano Today. 11 (2016) 7-12. (IF = 13.157)


2015年

1. Yu Gao, Biyu Jin, Weiyu Shen, Patrick Sinko, Xiaodong Xie, Huijuan Zhang, Lee Jia*. China and the United States- global partners, competitors and collaborators in nanotechnology development. Nanomedicine: Nanotechnology, Biology, and Medicine. 12 (2015) 13-19. (IF = 5.671)
2. Yu Gao*, Yazhen Li, Xiping Yang, Fangfei He, Jiamei Huang, Minghong Jiang, Zaihui Zhou, Haijun Chen*. Design, synthesis and biological evaluation of a novel coumarin-based fluorescence sensor for biological Cu2+ detection and chelation. RSC Advances 5 (2015), 80110-80117. (IF = 3.289)
3. Yu Gao, Ye Ding, Haiying Chen, Haijun Chen* and Jia Zhou*. Targeting krüppel-like factor 5 (KLF5) for cancer therapy. Current Topics in Medicinal Chemistry. 15 (2015) 699-713 (IF = 2.900)
4. Yu Gao*, Zhihong Li, Chaoqun Wang, Jiali You, Biyu Jin, Fan Mo, Jianzhong Chen, Yunquan Zheng, Haijun Chen*. Self-assembled chitosan/rose bengal derivative nanoparticles for targeted sonodynamic therapy: preparation and tumor accumulation. RSC Advances, 5 (2015) 17915 - 17923 (IF = 3.289)
5. Yu Gao*, Zhihong Li, Xiaodong Xie, Chaoqun Wang, Jiali You, Fan Mo, Biyu Jin, Jianzhong Chen, Jingwei Shao, Haijun Chen, Lee Jia*. Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: synthesis and biological evaluation. Eur. J. Pharm. Sci. 70 (2015) 55-63 (IF = 3.773)
6. Haijun Chen#, Yu Gao# (co-first author), Ailan Wang, Xiaobin Zhou, Yunquan Zheng, Jia Zhou*. Evolution in Medicinal Chemistry of Ursolic Acid Derivatives as Anticancer Agents. Eur. J. Med. Chem. 92 (2015) 648-655 (IF = 3.902)
7. Jingjing Xie, Yu Gao, Rongli Zhao, Patrick J. Sinko, Songen Gu, Jichuang Wang, Yuanfang Li, Yusheng Lu, Suhong Yu, Lie Wang, Shuming Chen, Jingwei Shao, Lee Jia. Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials. Journal of Controlled Release 209 (2015)159-169. (IF = 7.441)


2014年

1. Yu Gao, Jingwei Shao, Zhou Jiang, Songen Gu, Suhong Yu, Ke Zheng, Lee Jia*. Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discovery Today 19(2014)326-340. (IF = 5.625)
2. Yu Gao, Jingwei Shao, Zhou Jiang, Songen Gu, Suhong Yu, Ke Zheng, Lee Jia*. Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discovery Today 19(2014)326-340. (IF = 5.625)
3. Haijun Chen1, Yu Gao1 (co-first author), Jianlei Wu, Yingyu Chen, Buyuan Chen, Jianda Hub*, Jia Zhou*. Exploring Therapeutic Potentials of Baicalin and Its Aglycone Baicalein for Hematological Malignancies. Cancer Letters. 354(2014):5-11. (IF = 5.992)


2013年以前

1. Yu Gao1, Yu Chen1, Xiufeng Ji1, Xinyu He, Qi Yin, Zhiwen Zhang, Jianlin Shi, Yaping Li. Controlled intracellular release of doxorubicin in multidrug resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles. ACS Nano 5 (2011) 9788-9798. (IF = 12.033)
2. Yu Gao, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li. Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles. Biomaterials 32 (2011) 1738-1747. (IF = 8.312)
3. Qianjun He1, Yu Gao1 (co-first author), Lingxia Zhang, Zhiwen Zhang, Fang Gao, Xiufeng Ji, Yaping Li, Jianlin Shi. A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. Biomaterials 32 (2011) 7711-7720. (IF = 8.312)
4. Yu Gao1, Wangwen Gu1, Lingli Chen, Zhenghong Xu, Yaping Li. The role of daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for cardio-cerebrovascular diseases. Biomaterials 29 (2008) 4129-4136. (IF = 8.312)
5. Jianan Shen1, Qianjun He1, Yu Gao1 (co-first author), Jianlin Shi,Yaping Li. Mesoporous silica nanoparticles loading doxorubicin reverse multidrug resistance: performance and mechanism. Nanoscale 3 (2011) 4314-4322. (IF = 6.739)
6. Yu Gao1, Rongfu Yang1, Zhiwen Zhang, Lingli Chen, Zuyue Sun, Yaping Li. Solid lipid nanoparticles reduce systemic toxicity of docetaxel: performance and mechanism in animal. Nanotoxicology 5 (2011) 636-649. (IF = 7.336)
7. Yu Gao1, Wangwen Gu1, Lingli Chen, Zhenghong Xu, Yaping Li. A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection. Journal of Controlled Release 118 (2007) 381-388. (IF = 7.261)
8. Yu Gao, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li. Linear cationic click polymer for gene delivery: synthesis, biocompatibility, and in vitro transfection. Biomacromolecules 11 (2010) 3102-3111. (IF = 5.788)
9. Yu Gao, Zhiwen Zhang, Lingli Chen, Wangwen Gu, Yaping Li. Synthesis of 6-N,N,N-trimethyltriazole chitosan via “click chemistry” and evaluation for gene delivery. Biomacromolecules 10 (2009) 2175-2182. (IF = 5.788)
10. Yu Gao, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li. Linear cationic click polymers/DNA nanoparticles: in vitro structure-activity relationship and in vivo evaluation for gene delivery. Bioconjugate Chemistry 22 (2011) 1153-1161. (IF = 4.821)
11. Yu Gao1, Lingli Chen1, Wangwen Gu, Yong Xi, Liping Lin, Yaping Li. Targeted nanoassembly loaded with docetaxel improves intracellular drug delivery and efficacy in murine breast cancer model. Molecular Pharmaceutics 5 (2008) 1044-1054. (IF = 4.787)
12. Xiufeng Ji1, Yu Gao1 (co-first author), Lingli Chen, Zhiwen Zhang, Yihui Deng, Yaping Li. Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance. International Journal of Pharmaceutics 422 (2012) 390-397. (IF = 3.785)
13. Yu Gao1, Pengfei Xu1, Lingli Chen, Yaping Li. Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect. International Journal of Pharmaceutics 387 (2010) 263-271. (IF = 3.785)
14. Yu Gao, Wangwen Gu, Lingli Chen, Yaping Li. Chitosan N-betainates/DNA self-assembly nanoparticles for gene delivery: in vitro uptake and transfection efficiency. International Journal of Pharmaceutics 371 (2009) 156-162. (IF = 3.785)
15. Yu Gao, Zhenghong Xu, Chen Shangwei, Wangwen Gu, Lingli Chen,Yaping Li. Arginine-chitosan/DNA self-assemble nanoparticles for gene delivery: in vitro characteristics and transfection efficiency. International Journal of Pharmaceutics 359 (2008) 241-246. (IF = 3.785)
16. Yu Chen, Yu Gao, Hangrong Chen, Deping Zeng, Yaping Li, Yuanyi Zheng, Faqi Li, Xiufeng Ji, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang, Jianlin Shi. Engineering inorganic nanoemulsions/nanoliposomes by fluoride-silica chemistry for efficient delivery/co-delivery of hydrophobic agents. Advanced Functional Materials 22 (2012) 1586-1597. (IF = 10.439)
17. Qianjun He, Yu Gao, Lingxia Zhang, Wenbo Bu, Hangrong Chen, Yaping Li, Jianlin Shi. One-pot self-assembly of mesoporous silica nanoparticle-based pH-responsive anti-cancer nano drug delivery system. Journal of Materials Chemistry 21 (2011) 15190-15192. (IF = 6.626)
18. Qi Yin, Yu Gao, Zhiweng Zhang, Pengcheng Zhang, Yaping Li. Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery. Journal of Controlled Release 151 (2011) 35-44. (IF = 7.261)
19. Yongxin Yang, Yu Gao, Lingli Chen, Yongzhuo Huang, Yaping Li. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles. International Journal of Pharmaceutics 405 (2011)188-195. (IF = 3.785)
 

获奖情况
☆ 2016年福建省药学会药剂专业委员会学术年会优秀论文一等奖 (指导老师)
☆ 2016年福建省药学会药剂专业委员会学术年会优秀论文三等奖 (指导老师)
☆ 2015年中国药学会科技一等奖(第五完成人)
☆ 2015年福州大学化学学院本科生优秀毕业论文奖 (指导老师)
☆ 2015年福建省药学会药剂专业委员会学术年会优秀论文三等奖 (指导老师)
☆ 2014年福建省药学会药剂专业委员会学术年会优秀论文三等奖 (指导老师)
☆ 2014年福州大学本科生优秀毕业论文奖 (指导老师)
☆ 2013年福建省药学会药剂专业委员会学术年会优秀论文一等奖 (指导老师)
☆ 2013年上海药学科技一等奖(第五完成人)
☆ 2011年中国科学院百篇优秀博士论文
☆ 2010年中国科学院院长奖优秀奖
☆ 中科院2009-2010学年“三好学生标兵”
☆ 2010年中国微米纳米技术学会纳米科学技术分会第二届年会优秀墙报奖
☆ 2009年上海药学科技一等奖(第三完成人)
 

其他
 
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