姓    名: 刘见永
性    别:

 

职    称: 副教授
学    历: 博士
职    务:
电    话:
专    业: 有机化学与无机化学招生
电子邮件: liujianyong82@163.com
研究方向: 抗癌药物的设计、合成及活性评价

教育工作经历
2008.7 毕业于香港中文大学,获理学博士学位
2008.8-2010.8: 于香港中文大学化学系从事博士后研究
2010.10-至今: 福州大学化学学院工作
 

教学简介
承担本科生课程:
《有机化学》
《基础有机化学实验》
《综合实验》
承担研究生课程:
《有机化学研究方法》
《实验室安全讲座》
《现代有机合成实验》
 

科研简介
研究兴趣:
酞菁类抗癌光敏药物的设计与药效研究;
氟硼二吡咯类抗癌光敏药物的设计与药效研究;
染料敏化太阳能电池材料的设计及其光电转换性能研究;
酞菁和氟硼二吡咯的超分子化学;
荧光探针的设计及其生物标识。
 

社会兼职
 

科研项目
现主持:
1.国家自然科学基金:生物素介导靶向光动力治疗-化疗联用抗癌药物的合成及构效关系研究 (No.21401733)
2.国家自然科学基金:叶酸-酞菁共轭物抗癌光敏剂的合成及其靶向光动力活性 (No.21101028)
3.福建省自然科学基金:Cu(I)催化“点击化学”合成靶向抗癌光敏剂 (No.2012J05021)
4.引进人才项目:功能配合物 (No.022382)
5.科研启动项目:靶向抗癌光敏剂的研究 (No.600366)
6.科技发展基金:分子靶点抗癌光敏剂 (N0.2011-XY-6)

参与:
香港RGC Competitive Earmarked Research Grant课题3项
 

代表性论文
1. Liu, J.-Y.; Huang, Y.-S.; Menting, R.; Röder, B.; Ermilov, E. A.; Ng, D. K. P. “A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model” Chem. Commun. 2013, 49, 2998-3000.
2. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P. “A light-harvesting porphyrin-boron dipyrromethene conjugate” J. Porphyrins Phthalocyanines 2013, 17, 831-835.
3. Menting, R.; Liu, J.-Y.; Huang, Y.-S.; Ng, D. K. P.; Röder, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a p-phenylene-linked dyad of boron dipyrromethene and monostyryl boron dipyrromethene” Phys. Chem. Chem. Phys. 2013, 15, 6912-6919.
4. Zhang, F.-L.; Huang, Q.; Zheng, K.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* “A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib” Chem. Commun. 2013, 49, 9570-9572.
5. Jia, X.; Yang, F.-F.; Li, J.; Liu, J.-Y.; Xue, J.-P.* “Synthesis and in Vitro Photodynamic Activity of Oligomeric Ethylene Glycol?Quinoline Substituted Zinc(II) Phthalocyanine Derivatives” J. Med. Chem. 2013, 56, 5797-5805.
6. He, H.; Liu, J.-Y.; and Ng, D. K. P. “A Phthalocyanine-Based Fluorescent Sensor for Zn2+ Ion”, J. Porphyrins Phthalocyanines” 2013, 17, 99-103.
7. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P. “Photoinduced Electron Transfer in a Ferrocene-Distyryl BODIPY Dyad and a Ferrocene-Distyryl BODIPY-C60 Triad” ChemPhysChem, 2012, 13, 2030-3036.
8. Shi, W.-J.; Liu, J.-Y.; Ng, D. K. P. “A Highly Selective Colorimetric and Fluorescent Probe for Cu2+ and Hg2+ Ions Based on a Distyryl BODIPY with Two Bis(1,2,3-triazole)amino Receptors” Chem. Asian. J. 2012, 7(1), 174-179.
9. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P. “Mimicking the Photosynthetic Antenna-Reaction Center Complexes with a (Boron Dipyrromethene)3-Porphyrin-C60 Pentad” Chem. Eur. J. 2011, 17, 1605-1613.
10. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P. “Photoinduced Electron Transfer in a Distyryl BODIPY-Fullerene Dyad” Chem. Asian. J. 2011, 6, 174-179.
11. Liu, J.-Y.; Lo, P.-C.; Ng, D. K. P. “Phthalocyanine-Containing Supramolecular Arrays” Struct. Bond. 2010, 135, 169-210.
12. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P. “Switching the photo-induced energy and electron-transfer processes in BODIPY-phthalocyanine conjugates” Chem. Commun. 2009, 45, 1517-1519.
13. Liu, J.-Y.; Lo, P.-C.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P. “Synthesis and in vitro photodynamic activities of di-?-substituted zinc(II) phthalocyanine derivatives” Dalton Trans. 2009, 38, 4129-4135.
14. Liu, J.-Y.; Lo, P.-C.; Fong, W.-P.; Ng, D. K. P. “Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylated zinc(II) phthalocyanines” Org. Biomol. Chem. 2009, 7, 1583-1591.
15. Ermilov, E. A.; Liu, J.-Y.; Ng, D. K. P.; Röder, B. “Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine-boron dipyrromethene triads” Phys. Chem. Chem. Phys. 2009, 11, 6430-6440.
16. Liu, J.-Y.; Yeung, H.-S.; Xu, W.; Li, X.; Ng, D. K. P. “Highly Efficient Energy Transfer in Subphthalocyanine-BODIPY Conjugates” Org. Lett. 2008, 10(23), 5421-5424.
17. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P. “Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines. Effects of the chain length on the in vitro photodynamic activities” Org. Biomol. Chem. 2008, 6, 4560-4566.
18. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P. “Synthesis, Characterization, and in vitro Photodynamic Activities of Novel Amphiphilic Zinc(II) Phthalocyanines Bearing Oxyethylene-rich Substituents” Metal Based Drugs 2008, Article ID: 284691.
19. Lo, P.-C.; Chan, C. M. H.; Liu, J.-Y.; Fong, W.-P.; Ng, D. K.-P. “Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties” J. Med. Chem. 2007, 50(9), 2100-2107.

 

获奖情况
 

其他
 目前在有机化学硕士点招生,主要招收化学,生物专业的考生。
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