姓    名:    宋继彬
性    别:

      男 

职    称:

闽江学者 “特聘教授”

博士生导师

学    历: 博士
职    务:
电    话:
专    业:分析化学、材料工程,生物工程
电子邮件:jibinsong@fzu.edu.cn
研究方向:分析化学、材料工程、生物工程

 

教育工作经历

 2018.03-     福州大学,教授、博士生导师

 2014.06-2018.02 美国,国立卫生研究院,博士后

 2010.08-2014.07 新加坡,南洋理工大学,博士 

教学简介

 

科研简介  

主要研究内容包括:新型功能性机/无机纳米材料制备、生物医学工程、分析化学、分子影像、医学检测、新型药物载体等。累计发表SCI论文50余篇,其中以第一作者/通讯作者发表的影响因子大于10分的文章为23篇,主要包括Nat. Protoc.(1篇), Nat. Commoun. (1篇). Acc. Chem. Res. (1篇), Chem. Soc. Rev. (1篇), J. Am. Chem. Soc.(4篇), Angew. Chem. Int. Ed. (3篇), Adv. Mater. (5篇), ACS Nano (6篇), Adv. Funct. Mater. (1篇)等。


社会兼职

科研项目

 福州大学闽江学者特聘教授科研启动基金 (2018-2021)

 国家自然科学基金委面上项目(2019.01-2022.12)


代表性论文

2019

       (1)  Yang, Z.;# Song, J.;# Tang, W.;# Fan, W.; Dai, Y.; Shen, Z.; Lin, L.; Cheng, S.; Liu, Y.; Niu, G.; Rong, P.; Wang, W.;* Chen, X.* Stimuli-Responsive Nanotheranostics for Real-Time Monitoring Drug Release by Photoacoustic Imaging. Theranostics 2019, 9, 526-536.

       (2)  Lin, X.; Qiu, Y.; Song, L.; Chen, S.; Chen, X.; Huang, G.; Song, J.;* Chen, X.; Yang, H.* Ultrasound activation of liposomes for enhanced ultrasound imaging and synergistic gas and sonodynamic cancer therapy. Nanoscale Horizons 2019.

       (3)  Li, Z.; Guo, T.; Hu, Y.; Qiu, Y.; Liu, Y.; Wang, H.; Li, Y.; Chen, X.; Song, J.;* Yang, H.* A Highly Effective π-π Stacking Strategy to Modify Black Phosphorus with Aromatic Molecules for Cancer Theranostics. ACS Appl. Mat. Interfaces 2019.

       (4)  Li, S.; Liu, R.; Jiang, X.; Qiu, Y.; Song, X.; Huang, G.; Fu, N.; Lin, L.; Song, J.;* Chen, X.;* Yang, H.* Near-Infrared Light-Triggered Sulfur Dioxide Gas Therapy of Cancer. ACS Nano 2019.

       (5)  Guo, T.; Lin, Y.; Jin, G.; Weng, R.; Song, J.;Liu, X.; Huang, G.; Hou, L.; Yang, H. Manganese-phenolic network-coated black phosphorus nanosheets for theranostics combining magnetic resonance/photoacoustic dual-modal imaging and photothermal therapy. Chemical Communications 2019, 55, 850-853.

       (6)  Fu, Q.; Zhu, R.; Song, J.;* Yang, H.;* Chen, X.* Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications. Adv. Mater. 2019, 31, e1805875.

       (7)  Deng, H.; Dong, A.;  Song, J.;* Chen, X.* Injectable thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery. Journal of Controlled Release 2019, 297, 60-70.


2018

       (8)  Yu, G.; Yang, J.; Fu, X.; Wang, Z.; Shao, L.; Mao, Z.; Liu, Y.; Yang, Z.; Zhang, F.; Fan, W.; Song, J.; Zhou, Z.; Gao, C.; Huang, F.; Chen, X. A supramolecular hybrid material constructed from graphene oxide and a pillar[6]arene-based host–guest complex as an ultrasound and photoacoustic signal nanoamplifier. Materials Horizons 2018, 5, 429-435.

       (9)  Yang, Z.; Fan, W.; Tang, W.; Shen, Z.; Dai, Y.; Song, J.; Wang, Z.; Liu, Y.; Lin, L.; Shan, L.; Liu, Y.; Jacobson, O.; Rong, P.; Wang, W.; Chen, X. Hybrid of Near-Infrared Semiconducting Polymer Brush and pH/GSH-responsive Polyoxometalate Cluster for Enhanced Tumor-Specific Phototheranostics. Angew Chem Int Ed Engl 2018.

       (10) Yang, Z.; Dai, Y.; Yin, C.; Fan, Q.;* Zhang, W.; Song, J.; Yu, G.; Tang, W.; Fan, W.; Yung, B. C.; Li, J.; Li, X.; Li, X.; Tang, Y.; Huang, W.;  Song, J.;* Chen, X.* Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo. Adv. Mater. 2018, 30, e1707509.

       (11) Shen, Z.; Song, J.; Zhou, Z.; Yung, B. C.; Aronova, M. A.; Li, Y.; Dai, Y.; Fan, W.; Liu, Y.; Li, Z.; Ruan, H.; Leapman, R. D.; Lin, L.; Niu, G.; Chen, X.; Wu, A. Dotted Core-Shell Nanoparticles for T1 -Weighted MRI of Tumors. Adv. Mater. 2018, 30, e1803163.

       (12) Shen, Z.; Song, J.; Yung, B. C.; Zhou, Z.; Wu, A.; Chen, X. Emerging Strategies of Cancer Therapy Based on Ferroptosis. Adv. Mater. 2018, 30, e1704007.

       (13) Lin, L.-S.;# Song, J.;# Song, L.; Ke, K.; Liu, Y.; Zhou, Z.; Shen, Z.; Li, J.; Yang, Z.; Tang, W.; Niu, G.; Yang, H.-H.;* Chen, X.* Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent to Enhance Chemodynamic Therapy. Angewandte Chemie-International Edition 2018, 57, 4902-4906.

       (14) Lin, L. S.; Song, J.;* Yang, H. H.;* Chen, X.* Yolk-Shell Nanostructures: Design, Synthesis, and Biomedical Applications. Adv. Mater. 2018, 30, 1704639.

       (15) Huang, X.-W.; Wei, J.-J.; Zhang, M.-Y.; Zhang, X.-L.; Yin, X.-F.; Lu, C.-H.; Song, J.-B.; Bai, S.-M.; Yang, H.-H. Water-Based Black Phosphorus Hybrid Nanosheets as a Moldable Platform for Wound Healing Applications. ACS Appl. Mat. Interfaces 2018, 10, 35495-35502.

       (16) Huang, X.; Song, J.;* Yung, B. C.; Huang, X.; Xiong, Y.;* Chen, X.* Ratiometric optical nanoprobes enable accurate molecular detection and imaging. Chem. Soc. Rev. 2018, 47, 2873-2920.

       (17) Huang, X.; Liu, Y.; Barr, J.; Song, J.; He, Z.; Wang, Y.; Nie, Z.; Xiong, Y.; Chen, X. Controllable self-assembled plasmonic vesicle-based three-dimensional SERS platform for picomolar detection of hydrophobic contaminants. Nanoscale 2018, 10, 13202-13211.


2017

       (18) Zhou, Z.; Tian, R.; Wang, Z.; Yang, Z.; Liu, Y.; Liu, G.; Wang, R.; Gao, J.; Song, J.;* Nie, L.;* Chen, X.* Artificial local magnetic field inhomogeneity enhances T2 relaxivity. Nat Commun 2017, 8, 15468.

       (19) Zhou, Z.;# Song, J.;# Tian, R.; Yang, Z.; Yu, G.; Lin, L.; Zhang, G.; Fan, W.; Zhang, F.; Niu, G.; Nie, L.; Chen, X. Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy. Angew Chem Int Ed Engl 2017, 56, 6492-6496.

       (20) Yang, Z.; Tian, R.; Wu, J.; Fan, Q.;* Yung, B. C.; Niu, G.; Jacobson, O.; Wang, Z.; Liu, G.; Yu, G.; Huang, W.; Song, J.;* Chen, X.* Impact of Semiconducting Perylene Diimide Nanoparticle Size on Lymph Node Mapping and Cancer Imaging. ACS Nano 2017, 11, 4247-4255.

       (21) Yang, Z.; Song, J.;* Dai, Y.; Chen, J.; Wang, F.; Lin, L.; Liu, Y.; Zhang, F.; Yu, G.; Zhou, Z.; Fan, W.; Huang, W.; Fan, Q.;* Chen, X.* Self-Assembly of Semiconducting-Plasmonic Gold Nanoparticles with Enhanced Optical Property for Photoacoustic Imaging and Photothermal Therapy. Theranostics 2017, 7, 2177-2185.

       (22) Yang, X.; Wang, Z.; Zhang, F.; Zhu, G.; Song, J.; Teng, G.-J.; Niu, G.; Chen, X. Mapping Sentinel Lymph Node Metastasis by Dual-probe Optical Imaging. Theranostics 2017, 7, 153.

       (23) Song, J.; Yang, X.; Yang, Z.; Lin, L.; Liu, Y.; Zhou, Z.; Shen, Z.; Yu, G.; Dai, Y.; Jacobson, O.; Munasinghe, J.; Yung, B.; Teng, G. J.; Chen, X. Rational Design of Branched Nanoporous Gold Nanoshells with Enhanced Physico-Optical Properties for Optical Imaging and Cancer Therapy. ACS Nano 2017, 11, 6102-6113.

       (24) Song, J.; Wu, B.; Zhou, Z.; Zhu, G.; Liu, Y.; Yang, Z.; Lin, L.; Yu, G.; Zhang, F.; Zhang, G.; Duan, H.; Stucky, G. D.; Chen, X. Double-Layered Plasmonic-Magnetic Vesicles by Self-Assembly of Janus Amphiphilic Gold-Iron(II,III) Oxide Nanoparticles. Angew Chem Int Ed Engl 2017, 56, 8110-8114.

       (25) Song, J.; Niu, G.; Chen, X. Amphiphilic-Polymer-Guided Plasmonic Assemblies and Their Biomedical Applications. Bioconjug Chem 2017, 28, 105-114.

       (26) Shen, Z.; Chen, T.; Ma, X.; Ren, W.; Zhou, Z.; Zhu, G.; Zhang, A.; Liu, Y.; Song, J.;* Li, Z.; Ruan, H.; Fan, W.; Lin, L.; Munasinghe, J.; Chen, X.;* Wu, A.* Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging and Chemotherapy. ACS Nano 2017, 11, 10992-11004.

       (27) Lin, L. S.; Yang, X.; Zhou, Z.; Yang, Z.; Jacobson, O.; Liu, Y.; Yang, A.; Niu, G.; Song, J.;* Yang, H. H.;* Chen, X.* Yolk-Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic-Plasmonic Hybrid Theranostic Platform. Adv. Mater. 2017, 29, 1606681.

       (28) Chen, L. C.; Song, J. B.* Tailored Graphitic Carbon Nitride Nanostructures: Synthesis, Modification, and Sensing Applications. Advanced Functional Materials 2017, 27, 1702695.

       (29) Zhou, Z.; Song, J.; Nie, L.; Chen, X. Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy. Chemical Society Reviews 2016, 45, 6597-6626.


2016

       (30) Tong, X.; Wang, Z.; Sun, X.; Song, J.; Jacobson, O.; Niu, G.; Kiesewetter, D. O.; Chen, X. Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery. Theranostics 2016, 6, 2039-2051.

       (31) Song, J.; Wang, F.; Yang, X.; Ning, B.; Harp, M. G.; Culp, S. H.; Hu, S.; Huang, P.; Nie, L.; Chen, J.; Chen, X. Gold Nanoparticle Coated Carbon Nanotube Ring with Enhanced Raman Scattering and Photothermal Conversion Property for Theranostic Applications. Journal of the American Chemical Society 2016, 138, 7005–7015.

       (32) Song, J.; Huang, P.; Chen, X. Jibin*  Preparation of plasmonic vesicles from amphiphilic gold nanocrystals grafted with polymer brushes. Nat. Protoc. 2016, 11, 2287-2299.

       (33) Song, J.; Hu, H.; Jian, C.; Wu, K.; Chen, X. New Generation of Gold Nanoshell-Coated Esophageal Stent: Preparation and Biomedical Applications. ACS Appl. Mat. Interfaces 2016, 8, 27523-27529.

       (34) Liu, Y.; Wang, Z.; Zhang, H.; Lang, L.; Ma, Y.; He, Q.; Lu, N.; Huang, P.; Song, J.; Liu, Z.; Gao, S.; Ma, Q.; Kiesewetter, D. O.; Chen, X. A photothermally responsive nanoprobe for bioimaging based on Edman degradation. Nanoscale 2016, 8, 10553-10557.

       (35) Lin, L.-S.; Yang, X.; Niu, G.; Song, J.;* Yang, H.-H.;* Chen, X.* Dual-enhanced photothermal conversion properties of reduced graphene oxide-coated gold superparticles for light-triggered acoustic and thermal theranostics. Nanoscale 2016, 8, 2116-2122.

       (36) Lin, J.; Wang, M.; Hu, H.; Yang, X.; Wen, B.; Wang, Z.; Jacobson, O.; Song, J.; Zhang, G.; Niu, G.; Huang, P.; Chen, X. Multimodal-Imaging-Guided Cancer Phototherapy by Versatile Biomimetic Theranostics with UV and gamma-Irradiation Protection. Adv. Mater. 2016, 28, 3273-3279.

       (37) Huang, P.; Ling, D. S.; Song, J. B.; Liu, G.; Xie, J. Nanomaterials for Cancer Phototheranostics. Journal of Nanomaterials 2016, 2016.

       (38) Fan, J.; Song, J.; Liu, Y.; Yu, G.; Ma, Y.; Deng, Y.; He, N.; Zhang, F. Synthesis of biocompatible polymeric nanomaterial dually loaded with paclitaxel and nitric oxide for anti-MDR cancer therapy. RSC Advances 2016, 6, 105871-105877.

       (39) Fan, J.; He, Q.; Liu, Y.; Zhang, F.; Yang, X.; Wang, Z.; Lu, N.; Fan, W.; Lin, L.; Niu, G.; He, N.;* Song, J.;* Chen, X.* Light-Responsive Biodegradable Nanomedicine Overcomes Multidrug Resistance via NO-Enhanced Chemosensitization. ACS Appl. Mat. Interfaces 2016, 8 13804–13811.


2015

       (40) Tang, Y.; Hu, H.; Zhang, M. G.; Song, J.; Nie, L.; Wang, S.; Niu, G.; Huang, P.; Lu, G.; Chen, X. An aptamer-targeting photoresponsive drug delivery system using "off-on" graphene oxide wrapped mesoporous silica nanoparticles. Nanoscale 2015, 7, 6304-6310.

       (41) Song, J.; Yang, X.; Jacobson, O.; Lin, L.; Huang, P.; Niu, G.; Ma, Q.; Chen, X. Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy. ACS Nano 2015, 9, 9199-9209.

       (42) Song, J.; Yang, X.; Jacobson, O.; Huang, P.; Sun, X.; Lin, L.; Yan, X.; Niu, G.; Ma, Q.; Chen, X. Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy. Adv. Mater. 2015, 27, 4910-4917.

       (43) Song, J.; Huang, P.; Duan, H.; Chen, X. Plasmonic Vesicles of Amphiphilic Nanocrystals: Optically Active Multifunctional Platform for Cancer Diagnosis and Therapy. Acc. Chem. Res. 2015, 48, 2506-2515.

       (44) Huang, P.; Gao, Y.; Lin, J.; Hu, H.; Liao, H.-S.; Yan, X.; Tang, Y.; Jin, A.; Song, J.; Niu, G.; Zhang, G.; Horkay, F.; Chen, X. Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics. ACS Nano 2015, 9, 9517-9527.


2010-2014

       (45) Zhou, J.; Duan, B.; Fang, Z.; Song, J.; Wang, C.; Messersmith, P. B.; Duan, H. Interfacial assembly of mussel-inspired au@ag@ polydopamine core-shell nanoparticles for recyclable nanocatalysts. Adv. Mater. 2014, 26, 701-705.

       (46) Song, J.; Duan, B.; Wang, C.; Zhou, J.; Pu, L.; Fang, Z.; Wang, P.; Lim, T. T.; Duan, H. SERS-encoded nanogapped plasmonic nanoparticles: growth of metallic nanoshell by templating redox-active polymer brushes. Journal of the American Chemical Society 2014, 136, 6838-6441.

       (47) Wang, C.; Du, Y.; Wu, Q.; Xuan, S.; Zhou, J.; Song, J.; Shao, F.; Duan, H. Stimuli-responsive plasmonic core-satellite assemblies: i-motif DNA linker enabled intracellular pH sensing. Chemical Communications 2013, 49, 5739-5741.

       (48) Song, J.; Pu, L.; Zhou, J.; Duan, B.; Duan, H. Biodegradable Theranostic Plasmonic Vesicles of Amphiphilic Gold Nanorods. ACS Nano 2013, 7 9947–9960.

       (49) Song, J.; Fang, Z.; Wang, C.; Zhou, J.; Duan, B.; Pu, L.; Duan, H. Photolabile plasmonic vesicles assembled from amphiphilic gold nanoparticles for remote-controlled traceable drug delivery. Nanoscale 2013, 5, 5816-5824.

       (50) Fang, Z.; Wang, Y.; Song, J.; Sun, Y.; Zhou, J.; Xu, R.; Duan, H. Immobilizing CdS quantum dots and dendritic Pt nanocrystals on thiolated graphene nanosheets toward highly efficient photocatalytic H2 evolution. Nanoscale 2013, 5, 9830-9838.

       (51) Song, J.; Zhou, J.; Duan, H. Self-Assembled Plasmonic Vesicles of SERS-Encoded Amphiphilic Gold Nanoparticles for Cancer Cell Targeting and Traceable Intracellular Drug Delivery. Journal of the American Chemical Society 2012, 134, 13458-13469.

       (52) Yin, J.; Wu, T.; Song, J.; Zhang, Q.; Liu, S.; Xu, R.; Duan, H. SERS-Active Nanoparticles for Sensitive and Selective Detection of Cadmium Ion (Cd2+). Chemistry of Materials 2011, 23, 4756-4764.

       (53) Xiao, F.; Song, J.; Gao, H.; Zan, X.; Xu, R.; Duan, H. Coating Graphene Paper with 2D-Assembly of Electrocatalytic Nanoparticles: A Modular Approach toward High-Performance Flexible Electrodes. ACS Nano 2011, 6, 100–110.

       (54) Song, J.; Cheng, L.; Liu, A.; Yin, J.; Kuang, M.; Duan, H. Plasmonic Vesicles of Amphiphilic Gold Nanocrystals: Self-Assembly and External-Stimuli-Triggered Destruction. Journal of the American Chemical Society 2011, 133, 10760-10763.

       (55) Cheng, L.; Song, J. B.; Yin, J.; Duan, H. W. Self-Assembled Plasmonic Dimers of Amphiphilic Gold Nanocrystals. J. Phys. Chem. Lett. 2011, 2, 2258-2262.

       (56) Chen, Z. J.; Yu, D. X.; Liu, C. X.; Yang, X. Y.; Zhang, N.; Ma, C. H.; Song, J. B.; Lu, Z. J. Gadolinium-conjugated PLA-PEG nanoparticles as liver targeted molecular MRI contrast agent. Journal of drug targeting 2011, 19, 657-665.


PATENTS

1.Song, J. B, Lu, Z. J. Facile Synthesis of Primary amino-functionized poly(ethylene glycol)-poly(lactic acid) block copolymer (H2N-PEG-b-PLA). 2009, CN: 101555316 A.

2.Song, J. B, Lu, Z. J. Guangzhao Zhang, Na Zhang. An amphiphilic block copolymer Synthesis and its nanoparticle preparation. 2009, CN: 101565497.

3.Song, J. B, Chen, X. Y. Vesicle Containing Metallic Nanoparticle and Method for Production. Application No. USA62/266,289.


获奖情况

   “杰出博士后研究员”

   优秀海外博士留学生奖学金


其他

    课题组常年招收分析化学,材料化学,生物医学等相关专业的硕士、博士、科研助理、博士后,待遇优厚。有意向者请发送简历至邮箱:jibinsong@fzu.edu.cn

 

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