姓    名:江龙光
性    别:
职    称:副教授
学    历:博士
职    务:
电    话:0591-22867972
专    业:生物化学与分子生物学
电子邮件:jianglg@fzu.edu.cn
研究方向:结构生物学


教育工作经历

2016.02 – 至今:福州大学化学学院

2010.7 - 2016.1: 中国科学院福建物质结构研究所,助理研究员

2014.7 - 2014.10: 丹麦奥胡斯大学,访问学者

(合作者:Prof. Peter A. Andreasen

2005.9 - 2010.7: 中国科学院福建物质结构研究所,博士

(导师:黄明东 研究员)

2001.9 - 2005.7: 贵州大学,学士


教学简介

《生物化学A》;《分子与细胞生物学》;《化学综合实验》;《生物化学实验》

科研简介

主要从事结构生物学方面的研究,解析了多个重要蛋白质及其复合物的结构,包括了人源凝血因子XIa、血浆激肽释放酶(PK)、尿激酶与多肽抑制剂复合物晶体结构、尿激酶与抗体Fab-112复合物晶体结构、血小板内皮细胞黏附分子-1(PECAM-1)小角散射结构等。近年来,在重要国内外学术刊物上发表论文30余篇,其中16篇为第一作者或通讯作者,获得授权专利1项。 

 

社会兼职

福建省生物工程学会,理事


科研项目

1. 凝血和纤溶中的新机理和新疗法,国家重点研发计划项目(2017YFE0103200),研究骨干

2. 关键蛋白酶的结构研究及基于结构的抑制剂理性设计与改造,福建省科技厅面上项目(2018J01729),项目负责人 

3. 血小板内皮细胞黏附分子-1的结构研究,国家自然科学基金(31400637),项目负责人 

4. 抑制肿瘤转移的尿激酶多肽抑制剂的结构生物学研究,福建省科技厅青年创新项目(2012J05071),项目负责人 


代表性论文

16. Jiang L, Oldenburg E, Kromann-Hansen T, Xu P, Jensen JK, Andreasen PA, Huang M. Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Biochim Biophys Acta. 2018, Jun 26. pii: S0304-4165(18)30180-6.

15. Sun YG*, Li R*, Jiang L*, Qiao S, Zhi Y, Chen XX, Xie S, Wu J, Li X, Deng R, Zhang G. Characterization of the interaction between recombinant porcine aminopeptidase N and spike glycoprotein of porcine epidemic diarrhea virus. Int J Biol Macromol. 2018, May 24; 117:704-712. (*: Equal contributions).

14. Xie X, Xue G, Jiang L#, Huang M#. Ligand Induced Conformational Transitions of Tissue Factor Ω loop, Chinese J. Struct. Chem. 2018, 37(6), 961-968. (#: co-corresponding authors)

13. Xu M, Chen Y, Xu P, Andreasen PA, Jiang L#, Li J#, Huang M#. Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217. FEBS Lett. 2018 Aug;592(15):2658-2667. (#: co-corresponding authors)

12. Xu M, Xu P, Zhou X, Andreasen PA, Jiang L#, Huang M#. Crystal structures of the serine protease domain of murine plasma kallikrein, Chinese J. Struct. Chem. 2017, 36(2), 961-968. (#: co-corresponding authors)

11. Xue G, Gong L, Yuan C, Xu M, Wang X, Jiang L#, Huang M. A structural mechanism of flavonoids in inhibiting serine proteases. Food Funct. 2017 Jul 19;8(7):2437-2443. (#: co-corresponding authors)

10. Ma H, Qiao S, Huang M, Jiang L#, Li R#, Zhang G#. Crystal Structure of a CD163 Scavenger Receptor Cysteine-rich Domain Produced in Pichia PastorisChinese J. Struct. Chem. 2017, 36(9), 961-968. (#: co-corresponding authors)

9. Ma H*, Jiang L*, Qiao S, Zhi Y, Chen XX, Yang Y, Huang X, Huang M, Li R, Zhang GP. Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain (SRCR5) from Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection. J Virol. 2017 Jan 18;91(3). pii: e01897-16. (*: Equal contributions)

8. Jiang L, Lin L, Li R, Yuan C, Xu M, Huang JH, Huang M. Dimer conformation of soluble PECAM-1, an endothelial marker. Int J Biochem Cell Biol. 2016 Jun 3;77 (Pt A):102-108.

7. Jiang L, Andersen LM, Andreasen PA, Chen L, Huang M. Insights into the serine protease mechanism based on structural observations of the conversion of a peptidyl serine protease inhibitor to a substrate. Biochim Biophys Acta-General subjects. 2016 Mar; 1860 (3):599-606.

6. Jiang L, Zhao B, Xu P, Sørensen HP, Jensen JK, Christensen A, Hosseini M, Nielsen NC, Jensen KJ, Andreasen PA, Huang M. Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. Int J Biochem Cell Biol. 2015 May; 62:88-92.

5. Jiang L, Botkjaer KA, Andersen LM, Yuan C, Andreasen PA, Huang M. Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem J. 2013 Jan 1; 449 (1): 161-6.

4. Jiang L*, Svane AS*, Sørensen HP, Jensen JK, Hosseini M, Chen Z, Weydert C, Nielsen JT, Christensen A, Yuan C, Jensen KJ, Nielsen NC, Malmendal A, Huang M, Andreasen PA. The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor. J Mol Biol. 2011 412(2), 235-50. (*: Equal contributions).

3. Jiang L, Yuan, C, Chen, H, Wang, Y, Zhao, B, Zhang, X, and Huang, M, Preparation and structure of a new coagulation factor XI catalytic domain for drug discovery. Chinese J. Struct. Chem. 2011, 30 (7), 1021-59.

2. Jiang L, Zhao G, Bian C, Yuan C, Huang Z, Huang M. Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol. Chinese J. Struct. Chem. 200928(2), pp. 253-259.

1. Jiang, L, Yu H, Yuan C, Wang J, Chen L, Edward J. Meehan, Huang Z, Huang M. The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator. Chinese J. Struct. Chem. 2009, 28(11):1427-1432.


获奖情况

 

其他

专著

1. Iqbal Z, Jiang L, Chen Z, Yuan C, Li R, Zheng K, Zhou X, Chen J, Hu P, Huang M (2017) Tumor specific imaging and photodynamic therapy targeting on urokinase receptor, chapter 13, page 259-274. In “Imaging in Photodynamic Therapy” Edited by Michael R. Hamblin and Yingying Huang, Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742 CRC Press 2017 

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