姓    名:刘见永
性    别:

职    称:研究员(硕导、博导)
学    历:博士
职    务:
电    话:0591-22867105
专    业:有机化学
电子邮件:liujianyong82@163.com
研究方向:有机共轭大环化合物的合成及性能研究

 

教育工作经历

2011 - 2018      福州大学化学学院                      副研究员、研究员

2008-2010      香港中文大学化学系                  博士后

2005-2008      香港中文大学化学系                  博士


 教学简介

承担本科生课程:《有机化学》《综合化学实验》《有机化学实验》

承担研究生课程:《实验室安全讲座》《有机化学研究方法与实验》

科研简介

 研究兴趣:

氟硼二吡咯、酞菁类抗癌光敏药物的设计与药效研究;

有机染料分子荧光探针的设计及其在细胞、活体肿瘤中的成像研究;

染料敏化太阳能电池材料的设计及其光电转换性能研究;

酞菁和氟硼二吡咯的超分子化学。


 社会兼职

中国抗癌协会光动力治疗专业委员会委员

中国化学会应用化学学科委员会卟啉与酞菁专业委员会秘书

担任Chemical Communications, Journal of Medicinal Chemistry, Green Chemistry, Chemistry A European Journal, Organic Letters, RSC Advances, ChemMedChem, Current Medicinal Chemistry等期刊的通讯审稿人。

 

科研项目

 1.国家自然科学基金:生物素介导靶向光动力治疗-化疗联用抗癌药物的合成及构效关系研究    (No.21401733)  
2.国家自然科学基金:叶酸-酞菁共轭物抗癌光敏剂的合成及其靶向光动力活性 (No.21101028) 

3.福建省科技厅重大项目:抗癌光敏剂福大赛因临床 2期人体药代动力学研究(No. 2015Y0086)
4.福建省自然科学基金:Cu(I)催化“点击化学”合成靶向抗癌光敏剂 (No.2012J05021)  
5.福州大学海外引进人才项目:功能配合物 (No.022382)  
6.福州大学科研启动项目:靶向抗癌光敏剂的研究 (No.600366)    
7.福州大学科技发展基金:分子靶点抗癌光敏剂 (N0.2011-XY-6)


代表性论文

1. Chen, Y.; Liu, J.; Song, M.; Jiang, L.; Liu, L; Liu, Y.; Fu, G.; Xue, J.; Liu, J.-Y.*; Huang, M.*; Li,J*. “Insights into the binding mechanism of BODIPY-based photosensitizers to human serum albumin: A combined experimental and computational study”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 203, 158–165.

2. Lin, H.; Chen, J.; Zhang, Y.; Ullab, A.; Liu, J.-Y.; Lin, F.; Jiang, L.; Huang, M*. “Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine”, J. Inorg. Biochem., 2018, 189, 192–198.

3. Liu J.-Y*; Zhou, P.-Z.; Ma, J.-L. “Trifluoromethyl Boron Dipyrromethene Derivatives as Potential Photosensitizers for Photodynamic Therapy”, Molecules 2018, 23, 458-471.

4. Zhang, F.-L.; Song, M.-R.; Yuan, G.-K.; Ye, H.-N.; Tian, Y.; Huang, M.-D.; Xue, J.-P.; Zhang, Z.-H.*; Liu, J.-Y.* “A Molecular Combo of Zinc(II) Phthalocyanine and Tamoxifen Derivative for Dual Targeting Photodynamic Therapy and Hormone Therapy”J. Med. Chem., 2017, 60, 6693-6703.

5. Liu J.-Y*; Wang, C.; Zhu, C.-H.; Zhang, Z.-H.*; Xue, J.-P. “Preparation and In Vitro Photodynamic Activity of Glucosylated Zinc(II) Phthalocyanines as Underlying Targeting Photosensitizers”, Molecules 2017, 22, 845-857.

6. Liu, J.-Y.*; Hou, X.-N.; Tian, Y.; Jiang, L.*; Deng, S.; Röder, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a bis(triphenylamine)–BODIPY–C60 artificial photosynthetic system”, RSC Advances, 2016, 6, 57293-57305.

7. Liu, J.-Y.; Li, J.; Yuan, X.; Wang, W.-M.; Xue, J.-P.* “In vitro photodynamic activities of zinc(II) phthalocyanines substituted with pyridine moieties”, Photodiagnosis and Photodynamic Therapy, 2016, 13, 341-343.

8. Chen, J.; Ye, H.; Zhang, M.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* “Erlotinib Analogue-substituted Zinc(II) Phthalocyanines for Small Molecular Target-based Photodynamic Cancer Therapy”, Chin. J. Chem., 2016, 34, 983-988.

9. Ermilov, E. A. *; Liu, J.-Y.; Menting, R.; Huang, Y.-S.; Röder, B.; Ng, D. K. P.* “An artificial photosynthetic model based on a molecular triad of boron dipyrromethene and phthalocyanine” Phys. Chem. Chem. Phys., 2016, 18, 10964-10975.

10. Zhang, F.-L.; Huang, Q.; Liu, J.-Y.; Huang, M.-D.; Xue, J.-P.* “Molecular-Target-Based Anticancer Photosensitizer: Synthesis and in vitro Photodynamic Activity of Erlotinib–Zinc(II)Phthalocyanine Conjugates” ChemMedChem, 2015, 10(2), 312-320.

11. Ermilov, E. A.*; Schlak, M.; Steffen, R.; Liu, X.-Q.; Liu, J.-Y.; Röder, B. “Energy transfer properties of a novel boron dipyrromethene–perylenediimide donor–acceptor dyad” RSC Adv., 2015, 5, 67141-67148.

12. Zhou, X.-Q.; Meng, L.-B.; Huang, Q.; Li, J.; Zheng, K.; Zhang, F.-L.; Liu, J.-Y.; Xue, J.-P.* “Synthesis and in vitro Anticancer Activity of Zinc(II) Phthalocyanines Conjugated with Coumarin Derivatives for Dual Photodynamic and Chemotherapy” ChemMedChem, 2015, 10, 304-311.

13. Lin, J.; Zhu, C.; Liu, X.; Chen, B.; Zhang, Y.; Xue, J.;Liu, J.-Y.* “A Highly Selective and turn-on fluorescence probe for Fe3+ ion based on perylene tetracarboxylic diimide” Chin. J. Chem., 2014, 32, 1116-1120.

14. Jia, X.; Yue, F.; Chen, X.; Pan, H.-B.; Liu, W.-G.*; Liu, J.-Y.* “One-pot controlled synthesis of single-crystal a-Fe2O3 hollow nanostructure and its gas sensing properties” RSC Adv., 2014, 4, 42899-42904.

15. Liu, J.-Y.; Huang, Y.-S.; Menting, R.; Röder, B.; Ermilov, E. A.; Ng, D. K. P.* “A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model” Chem. Commun. 2013, 49, 2998-3000.

16. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “A light-harvesting porphyrin-boron dipyrromethene conjugate” J. Porphyrins Phthalocyanines 2013, 17, 831-835.

17. Menting, R.;Liu, J.-Y.;Huang, Y.-S.;Ng, D. K. P.;Röder, B.;Ermilov, E. A.* “Photoinduced energy and charge transfer in a p-phenylene-linked dyad of boron dipyrromethene and monostyryl boron dipyrromethene” Phys. Chem. Chem. Phys. 2013, 15, 6912-6919.

18. Zhang, F.-L.; Huang, Q.; Zheng, K.; Li, J.;Liu, J.-Y.*; Xue, J.-P.* “A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib” Chem. Commun. 2013, 49, 9570-9572.

19. Jia, X.; Yang, F.-F.; Li, J.; Liu, J.-Y.; Xue, J.-P.*“Synthesis and in Vitro Photodynamic Activity of Oligomeric Ethylene Glycol−Quinoline Substituted Zinc(II) Phthalocyanine Derivatives” J. Med. Chem. 2013, 56, 5797-5805.

20. He, H.; Liu, J.-Y.; and Ng, D. K. P.* “A Phthalocyanine-Based Fluorescent Sensor for Zn2+ Ion”, J. Porphyrins Phthalocyanines2013, 17, 99-103.

21. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Ferrocene-Distyryl BODIPY Dyad and a Ferrocene-Distyryl BODIPY-C60 Triad” ChemPhysChem, 2012, 13, 2030-2036.

22. Shi, W.-J.; Liu, J.-Y.; Ng, D. K. P.* “A Highly Selective Colorimetric and Fluorescent Probe for Cu2+ and Hg2+ Ions Based on a Distyryl BODIPY with Two Bis(1,2,3-triazole)amino Receptors Chem. Asian. J. 2012,7(1), 196-200.

23. Liu, J.-Y.; El-Khouly, M. E.; Fukuzmi, S.*; Ng, D. K. P.* “Mimicking the Photosynthetic Antenna-Reaction Center Complexes with a (Boron Dipyrromethene)3-Porphyrin-C60 Pentad”Chem. Eur. J. 2011,17, 1605-1613.

24. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Distyryl BODIPY-Fullerene Dyad” Chem. Asian. J. 2011,6, 174-179.

25. Liu, J.-Y.; Lo, P.-C.; Ng, D. K. P.* “Phthalocyanine-Containing Supramolecular Arrays” Struct. Bond. 2010, 135, 169-210.

26. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “Switching the photo-induced energy and electron-transfer processes in BODIPY-phthalocyanine conjugates” Chem. Commun. 2009, 45, 1517-1519.

27. Liu, J.-Y.; Lo, P.-C.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis and in vitro photodynamic activities of di--substituted zinc(II) phthalocyanine derivatives” Dalton Trans. 2009, 38, 4129-4135.

28. Liu, J.-Y.; Lo, P.-C.; Fong, W.-P.; Ng, D. K. P.* “Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylated zinc(II) phthalocyanines” Org. Biomol. Chem. 2009, 7, 1583-1591.

29. Ermilov, E. A.*; Liu, J.-Y.; Ng, D. K. P.*; Röder, B. “Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine-boron dipyrromethene triads” Phys. Chem. Chem. Phys. 2009, 11, 6430-6440.

30. Liu, J.-Y.; Yeung, H.-S.; Xu, W.; Li, X.; Ng, D. K. P.* “Highly Efficient Energy Transfer in Subphthalocyanine-BODIPY Conjugates” Org. Lett. 2008, 10(23), 5421-5424.

31. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines.  Effects of the chain length on the in vitro photodynamic activities” Org. Biomol. Chem. 2008, 6, 4560-4566.

32. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis, Characterization, and in vitro Photodynamic Activities of Novel Amphiphilic Zinc(II) Phthalocyanines Bearing Oxyethylene-rich Substituents” Metal Based Drugs 2008, Article ID: 284691.

33. Lo, P.-C.; Chan, C. M. H.;Liu, J.-Y.; Fong, W.-P.; Ng, D. K.-P.* Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties” J. Med. Chem. 2007, 50(9), 2100-2107.

 

获奖情况

 

 

其他

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