姓    名:柯美荣
性    别:

 

职    称:副教授
学    历:博士
职    务:
电    话:
专    业:药物化学
电子邮件:K107079@163.com
研究方向:医用功能材料

 

教育工作经历

2013.3至今 福州大学 化学学院工作;
2009.8-2012.12 香港中文大学 化学系 博士;
2004.9-2007.7 福州大学 化学化工学院 硕士;
2000.9-2004.7 福建师范大学 化学系 学士
 

 

教学简介

本科课程:《有机化学》、《有机实验》

研究生课程:《药学综合实验》、《实验室安全讲座》、《药学研究方法与实验》 

 

科研简介

研究兴趣:
酞菁类光敏剂的抗菌活性研究
肿瘤靶向纳米光敏药物的研究

 

社会兼职

 

 

科研项目

 国家自然科学基金、福建省自然科学基金、引进人才项目、科研启动基金、福州大学科技发展基金

代表性论文

1. A.-L. Lin, S.g-Z. Li, C.-H. Xu, X. Li, B.-Y. Zheng, J.-J. Gu, M.-R. Ke*, J.-D. Huang*. A pH-responsive stellate mesoporous silica based nanophotosensitizer for in vivo cancer diagnosis and targeted photodynamic therapy. Biomater. Sci. 2019, 7, 211-219.

2. X.-H. Peng, S.-F. Chen, C.-H. Xu, B.-Y. Zheng, M.-R. Ke*, J.-D. Huang*. Synthesis, Spectroscopic and Fibroblast Activation Protein (FAP)-Responsive Properties of Phthalocyanine-Doxorubicin Conjugates. ChemSelect 2018, 3, 5405-5411.

3. X. Li,  S. Yu,  D. Lee, G. Kim, B. Lee,  Y. Cho, B.-Y. Zheng, M.-R. Ke, J.-D. Huang*, et al. Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy. ACS Nano 2018, 12, 681-688.

4. X. Li, X.-H. Peng, B.-D. Zheng, J. Tang, Y. Zhao,  B.-Y. Zheng, M.-R. Ke, J.-D. Huang*. New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates. Chem. Sci. 2018, 9, 2098-2104.

5. F.-X. Tang*, H.-C. Li, X.-D. Ren, Y. Sun, W. Xie, C.-Y. Wang, B.-Y. Zheng, M.-R. Ke, J.-D. Huang*. Preparation and antifungal properties of monosubstituted zinc(II) phthalocyanine-chitosan oligosaccharide conjugates and their quaternized derivatives. Dyes Pigments 2018,159, 439-448.

6. M.-R. Ke, S.-F. Chen, X.-H. Peng, Q.-F. Zheng, B.-Y. Zheng, C.-K. Yeh, J.-D. Huang*. A tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy. Eur. J. Med. Chem. 2017, 127, 200-209.

7. Q. Sun, B.-Y. Zheng, Y.-H. Zhang, J.-J. Zhuang, M.-R. Ke*, Jian-Dong Huang*. Highly photocytotoxic silicon(IV) phthalocyanines axially modified with L-tyrosine derivatives: Effects of mode of axial substituent connection and of formulation on photodynamic activity. Dyes Pigments 2017, 141, 521-529.

8. X. Li, B.-Y. Zheng, M.-R. Ke, Y. Zhang, J.-D. Huang*, J. Yoon*. A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity. Theranostics 2017, 7, 2746-2756.

9.. X.-H. Peng, S.-F.Chen, B.-Y. Zheng, B.-D. Zheng, Q.-F. Zheng, X. Li, M.-R. Ke, J.-D. Huang*. Comparison between amine-terminated phthalocyanines and their chlorambucil conjugates: Synthesis, spectroscopic properties, and in vitro anticancer activity. Tetrahedron 2017, 73, 378-384.

10. D.-H. Wan, B.-Y. Zheng, R.-M. Ke, J.-Y. Duan, Y.-Q. Zheng, C.-K. Yeh, J.-D. Huang*. C-Phycocyanin as a tumour-associated macrophage-targeted photosensitiser and a vehicle of phthalocyanine for enhanced photodynamic therapy. Chem. Commun. 2017, 53, 4112-4115.

11. B.-Y. Zheng, M.-R. Ke, W.-L. Lan, L. Hou, J. Guo, D.-H. Wan, L.-Z. Cheong, J.-D. Huang*. Mono- and tetra-substituted zinc(II) phthalocyanines containing morpholinyl moieties: Synthesis, antifungal photodynamic activities, and structure-activity relationships. Eur. J. Med. Chem. 2016, 114, 380-389. (Coauthor)

12. B.-Y. Zheng, X.-M. Shen, D.-M. Zhao, Y.-B. Cai, M.-R. Ke, J.-D. Huang*. Silicon(IV) phthalocyanines substituted axially with different nucleoside moieties. Effects of nucleoside type on the photosensitizing efficiencies and in vitro photodynamic activities. J. Photochem. Photobiol. B 2016, 159, 196-204.

13. W.-L. Lan, F.-R. Liu, M.-R. Ke, P.-C. Lo, W.-P. Fong, D. K. P. Ng*, J.-D. Huang*. The effects of formulation and serum albumin on the in vitro photodynamic activity of zinc(II) phthalocyanines substituted with sulfonated quinolineoxy groups. Dyes Pigments 2016, 128, 215-225.

14.  X. Li, M.-R. Ke, W. Huang, C.-H. Ye, J.-D. Huang*. A pH-Responsive Layered Double Hydroxide (LDH)–Phthalocyanine Nanohybrid for Efficient Photodynamic Therapy. Chem. Eur. J. 2015, 21, 3310-3317. (Coauthor)

15.X. Li, M.-R. Ke, M.-F. Zhang, Q.-Q. Tang, B.-Y. Zheng, J.-D. Huang*. A non-aggregated and tumour-associated macrophage-targeted photosensitiser for photodynamic therapy: a novel zinc(II) phthalocyanine containing octa-sulphonates. Chem. Commun. 2015, 51, 4704-4707.

16. X. Li, J. Guo, J.-J. Zhuang, B.-Y. Zheng, M.-R. Ke, J.-D. Huang*. Highly positive-charged zinc(II) phthalocyanine as non-aggregated and efficient antifungal photosensitizer. Bioorg. Med. Chem. Lett. 2015, 25, 2386-2389.

17. B.-Y. Zheng, X.-J. Jiang, T. Lin, M.-R. Ke, J.-D. Huang*. Novel silicon(IV) phthalocyanines containing piperidinyl moieties:Synthesis and in vitro antifungal photodynamic activities. Dyes Pigments 2015,112, 311-316.

18. H.-N. Xu, H.-J. Chen, B.-Y. Zheng, Y.-Q. Zheng, M.-R. Ke, J.-D. Huang*. Preparation and sonodynamic activities of water-soluble tetra-a-(3-carboxyphenoxyl) zinc(II) phthalocyanine and its bovine serum albumin conjugate. Ultrason. Sonochem.  2015, 22, 125-131.

19. M.-R. Ke, D. K. P. Ng*, P.-C. Lo*. Synthesis and In Vitro Photodynamic Activities of an Integrin-Targeting cRGD-Conjugated Zinc(II) Phthalocyanine. Chem. Asian J. 2014, 9, 554-561.

20. M.-R. Ke, J. M. Eastel, K. L. K. Ngai, Y.-Y. Cheung, P. K. S. Chan, M. Hui, D. K. P. Ng*, P.-C. Lo*. Oligolysine-Conjugated Zinc(II) Phthalocyanines as Efficient Photosensitizers for Antimicrobial Photodynamic Therapy. Chem. Asian J. 2014, 9, 1868-1875.

21. M.-R. Ke, J. M. Eastel, K. L. K. Ngai, Y.-Y. Cheung, P. K. S. Chan, M. Hui, D. K. P. Ng*, P.-C. Lo*. Photodynamic Inactivation of Bacteria and Viruses Using Two Monosubstituted Zinc(II) Phthalocyanines, Eur. J. Med. Chem. 2014, 84, 278-283.

22. Y.-W. Zheng, S.-F. Chen, B.-Y. Zheng, M.-R. Ke, J.-D. Huang*. A Silicon(IV) Phthalocyanine­Folate Conjugate as an Efficient Photosensitizer. Chem. Lett. 2014, 43, 1701-1703.

23. M.-R. Ke, S.-L. Yeung, D. K. P. Ng*, W.-P. Fong, P.-C. Lo*. Preparation and in Vitro Photodynamic Activities of Folate-Conjugated Distyryl Boron Dipyrromethene Based Photosensitizers, J. Med. Chem.  2013, 56, 8475-8483.

24. X.-W. Chen, M.-R. Ke, X. Li, W.-L. Lan, M.-F. Zhang, J.-D. Huang*. Synthesis, Supramolecular Behavior, and In Vitro Photodynamic Activities of Novel Zinc(II) Phthalocyanines “Side-strapped” with Crown Ether Bridges, Chem. Asian J. 2013, 812, 3063-3070. (Coauthor)

25. B.-Y. Zheng, H.-P. Zhang, M.-R. Ke, J.-D. Huang*.Synthesis and antifungal photodynamic activities of a series of novel zinc(II) phthalocyanines substituted with piperazinyl moieties. Dyes Pigments 2013, 99,185-191.

26. M.-R. Ke, S.-L. Yeung, W.-P. Fong, D. K. P. Ng*, P.-C.i Lo*. A Phthalocyanine-Peptide Conjugate with High In Vitro Photodynamic Activity and Enhanced In Vivo Tumor-Retention Property, Chem. Eur. J. 2012, 18, 4225-4233.

27. M.-R. Ke, D. K. P. Ng*, P.-C. Lo*, A pH-responsive Fluorescent Probe and Photosensitiser Based on a Self-quenched Phthalocyanine Dimer, Chem. Commun. 2012, 48, 9065-9067.

 

 

获奖情况

 

 

其他

 

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