姓    名:陈兆委
性    别:

职    称:教授
学    历:博士
职    务:
电    话:
专    业:分析化学、材料工程、化学生物学
电子邮件:chenzw@fzu.edu.cn|zhaowei_chen@126.com
研究方向:人工细胞、生物催化、纳米诊疗


教育与工作经历

2020.02至今 福州大学,教授、博士生导师

2019.03-2020.01 美国,加州大学洛杉矶分校,博士后 (导师:Zhen Gu

2017.06-2019.03美国,阿贡国家实验室,博士后 (导师:Elena A. Rozhkova

2016.04-2017.06美国,北卡罗莱纳大学,博士后 (导师:Zhen Gu

2010.09-2016.01中科院长春应化所,博士 (导师:任劲松&曲晓刚)

2006.09-2010.07西北工业大学,本科

 科研简介

主要从事生命分析化学及化学生物学相关的基础与应用研究。在仿生材料的构建(如仿生人工细胞、人工模拟酶、微型反应器、仿生矿化等)及其应用于药物载体、生物催化、抗菌抗生物被膜等方面进行探索。近年来已在相关领域发表SCI论文70余篇,其中第一作者/通讯作者论文19篇,包括:Nat. Chem. Biol., Sci. China Life Sci., Nat. Nanotechnol. (News & Views), J. Am. Chem. Soc. (2篇), Angew. Chem. Int. Ed. (3篇), Adv. Mater., Adv. Funct. Mater., Chem. Soc. Rev., Acc. Chem. Res. (3篇), Biomaterials (2篇), Biosens. Bioelectron., Chem. Commun., Chem. Eur. J.。总引用次数2800余次,H-因子33。工作多次被Nature Nanotechnology, Nature Methods, JAMA等亮点报道。荣获中科院优秀博士学位论文,中科院朱李月华优秀博士生奖,博士研究生国家奖学金等。

科研项目

福州大学“闽江学者”特聘教授科研启动基金 (2020-2023)

代表性论文

1. Z. Chen*, D. Wen, Z. Gu* (2020). “Cargo-Encapsulated Cells for Drug Delivery.” Science China Life Science, DOI: 10.1007/s11427-020-1653-y. (IF= 3.583)

      2. Z. Chen, J. Wang, W. Sun, E. Archibong, A. R. Kahkoska, X. Zhang, Y. Lu, F. S. Ligler, J. B. Buse and Z. Gu (2018). "Synthetic beta cells for fusion-mediated dynamic insulin secretion." Nature Chemical Biology,14, 86. (IF=12.154)

       3. Z. Chen, E. A. Rozhkova (2018) “Intracellular gold nanoclusters boost energy conversion.” Nature Nanotechnology, 13, 880-881. (News and Views, IF= 33.407)

       4. Z. Chen, H. Zhang, P. Guo, J. Zhang, G. Tira, Y. J. Kim, Y. A. Wu, Y. Liu, J. Wen, T. Rajh, J. Niklas, O. G. Poluektov, P. D. Laible and E. A. Rozhkova (2019). “Semi-Artificial Photosynthetic CO2 Reduction Through Purple Membrane Re-engineering with Semiconductor.” Journal of the American Chemical Society, 141, 11811-11815. (IF = 14.695)

       5. Z. Chen, G. De Queiros Silveira, X. Ma, Y. Xie, Y. A. Wu, E. Barry, T. Tajh, H. C. Fry, P. D.Laible, E. A. Rozhkova (2019)“Light-Gated Synthetic Protocells for Plasmon-Enhanced Chemiosmotic Gradient Generation and ATP Synthesis.”Angewandte Chemie International Edition, 58, 4896–4900. (IF = 12.257)

6. Z. Chen, H. Ji, C. Liu, W. Bing, Z. Wang and X. Qu (2016). "A Multinuclear Metal Complex Based DNase-Mimetic Artificial Enzyme: Matrix Cleavage for Combating Bacterial Biofilms." Angewandte Chemie International Edition, 55(36), 10732-10736. (IF = 12.257)

7. Z. Chen, C. Zhao, E. Ju, H. Ji, J. Ren, B. P. Binks, X. Qu (2016). “Design of Surface-active Artificial Enzyme Particles to Stabilize Pickering Emulsions for High-Performance Biphasic Biocatalysis.” Advanced Materials, 28(8), 1682-1688. (IF = 25.809)

8. Z. Chen, H. Ji, C. Zhao, E. Ju, J. Ren and X. Qu (2015). "Individual Surface-Engineered Microorganisms as Robust Pickering Interfacial Biocatalysts for Resistance-Minimized Phase-Transfer Bioconversion." Angewandte Chemie International Edition, 54(16), 4904-4908. (IF = 12.257)

9. Z. Chen, L. Zhou, W. Bing, Z. Zhang, Z. Li, J. Ren and X. Qu (2014). "Light Controlled Reversible Inversion of Nanophosphor-Stabilized Pickering Emulsions for Biphasic Enantioselective Biocatalysis." Journal of the American Chemical Society, 136(20), 7498-7504. (IF = 14.695)

10. Z. Chen, Z. Li, J. Wang, E. Ju, L. Zhou, J. Ren and X. Qu (2014). "A Multi-synergistic Platform for Sequential Irradiation-Activated High-Performance Apoptotic Cancer Therapy." Advanced Functional Materials, 24(4), 522-529. (IF = 15.621)

11. Z. Chen, Z. Wang, Z. Gu (2019) “Bioinspired and Biomimetic Nanomedicines” Accounts of Chemical Research, 52, 1255-1264. (IF=21.661)

12. Z. Chen,Q. Hu, and Z. Gu (2018). “Leveraging Engineering of Cells for Drug Delivery.” Accounts of Chemical Research,51, 668-677. (IF=21.661)

13. Z. Chen,C. Liu, F. Cao, J. Ren and X. Qu (2018). “DNA Metallization: Principles, Methods, Structures and Applications.” Chemical Society Reviews, 47, 4017-4072. (IF=40.443)

14. Z. Chen, Z. Wang, J. Ren and X. Qu (2018). “Enzyme Mimicry for Combating Bacterial and Biofilms.” Accounts of Chemical Research, 51, 789-799. (IF=21.661)

15. Z. Chen, Z. Liu, Z. Li, E. Ju, N. Gao, L. Zhou, J. Ren and X. Qu (2015). "Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis." Biomaterials, 39, 15-22. (IF = 10.273)

16. Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren and X. Qu (2013). "Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery." Biomaterials, 34(4), 1364-1371. (IF = 10.273)

17. Z. Chen, L. Zhou, A. Zhao, Z. Zhang, Z. Wang, Y. Lin, J. Ren and X. Qu (2014). "Coupling exonuclease III with DNA metallization for amplified detection of biothiols at picomolar concentration." Biosensors & Bioelectronics, 58, 214-218. (IF = 9.518)

18. Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren and X. Qu (2013). "Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery." Chemistry-a European Journal, 19(5), 1778-1783. (IF = 5.160)

19. Z. Chen, Y. Lin, C. Zhao, J. Ren and X. Qu (2012). "Silver metallization engineered conformational switch of G-quadruplex for fluorescence turn-on detection of biothiols." Chemical Communications, 48(93), 11428-11430. (IF = 6.164)

20. de Q. Silveira, G.,[+] Z. Chen,[+] E. F. Barry, B. T. Diroll, B. Lee, T. Rajh, E. A. Rozhkova, P. D. Laible, and H. C. Fry. (2019). “Energy Transfer Induced by Dye Encapsulation in a Hybrid Nanoparticle-Purple Membrane Reversible Assembly.” Advanced Functional Materials 29 (43):1904899. (IF = 15.621)

21. H.-C. Yang,[+] Z. Chen,[+] Y. Xie,[+] J. Wang, J. W. Elam, W. Li and S. B. Darling (2018) "Chinese Ink: A Powerful Photothermal Material for Solar Steam Generation." Advanced Materials Interfaces, 1801252, 1–7. (Inside Front Cover) (IF=4.713)

22. Z.-J. Xia,[+] H.-C. Yang,[+] Z. Chen,[+] R. Z. Waldman, Y. Zhao,; C. Zhang, S. N. Patel, and S. B Darling. “Porphyrin Covalent Organic Framework (POF)-Based Interface Engineering for Solar Steam Generation.” Advanced Materials Interfaces, 0, 1900254. (Inside Back Cover)(IF=4.713)

23. W. Li, Z. Chen, L. Zhou, Z. Li, J. Ren and X. Qu (2015). "Noninvasive and Reversible Cell Adhesion and Detachment via Single-Wavelength Near-Infrared Laser Mediated Photoisomerization." Journal of the American Chemical Society, 137(25), 8199-8205. (IF = 14.695)

24. L. Zhou, Z. Chen, K. Dong, M. Yin, J. Ren and X. Qu (2014). “DNA-mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near- Infrared Light Triggered Release.” Advanced Materials 26(15), 2424-2430. (IF = 25.809)

25. Z. Wang, Z. Chen, N. Gao, J. Ren and X. Qu (2015). "Transmutation of Personal Glucose Meters into Portable and Highly Sensitive Microbial Pathogen Detection Platform." Small, 11(37), 4970-4975. (IF = 10.856)

26. L. Zhou, Z. Chen, K. Dong, M. Yin, J. Ren and X. Qu (2014). "DNA-mediated biomineralization of rare-earth nanoparticles for simultaneous imaging and stimuli-responsive drug delivery." Biomaterials, 35(30), 8694-8702. (IF = 10.273)

27. Z. Wang, Z. Chen, Z. Liu, P. Shi, K. Dong, E. Ju, J. Ren and X. Qu (2014). "A multi-stimuli responsive gold nanocage-hyaluronic platform for targeted photothermal and chemotherapy." Biomaterials, 35(36), 9678-9688. (IF = 10.273)

28. X. Zhang, J. Wang, Z. Chen, Q. Hu, C. Wang, J. Yan, G. Dotti, P. Huang and Z. Gu (2018). "Engineering PD-1-Presenting Platelets for Cancer Immunotherapy." Nano Letters, 18(9), 5716-5725. (IF=12.279)

29. Lu, Y., Y. Lin, Z. Chen, Q. Hu, Y. Liu, S. Yu, W. Gao, M. D. Dickey and Z. Gu (2017). "Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer." Nano Letters, 17(4), 2138-2145. (IF=12.279)

30. E. Ju, K. Dong, Z. Chen, Z. Liu, C. Liu, Y. Huang, Z. Wang, F. Pu, J. Ren and X. Qu (2016). "Copper(II)–Graphitic Carbon Nitride Triggered Synergy: Improved ROS Generation and Reduced Glutathione Levels for Enhanced Photodynamic Therapy." Angewandte Chemie International Edition, 55(38), 11467-11471. (IF = 12.257)

31. Y. Lin, Z. Li, Z. Chen, J. Ren and X. Qu (2013). "Mesoporous silica-encapsulated gold nanoparticles as artificial enzymes for self-activated cascade catalysis." Biomaterials, 34(11), 2600-2610. (IF = 10.273)

32. Yang, G., Q. Chen, D. Wen, Z. Chen, J. Wang, G. Chen, Z. Wang, X. Zhang, Y. Zhang, Q. Hu, L. Zhang, and Z. Gu.(2019). “A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth.”ACS Nano 13 (4):4354-4360. (IF = 13.903)

33. C. Gu., H.-N. Nguyen, D. Ganini, Z. Chen, H. J. Jessen, Z. Gu, H. Wang and S. B. Shears (2017). "KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype." Proceedings of the National Academy of Sciences, 114(45), 11968-11973. (IF = 9.580)

34. C. Liu, Y. Zhang, M. Liu, Z. Chen, Y. Lin, W. Li, F. Cao, Z. Liu, J. Ren and X. Qu (2017). A NIR-controlled cage mimicking system for hydrophobic drug mediated cancer therapy. Biomaterials, 139(Supplement C),151-162. (IF = 10.273)

35. Y. Zhang, F. Wang, E. Ju, Z. Liu, Z. Chen, J. Ren and X. Qu (2016). "Metal-Organic-Framework-Based Vaccine Platforms for Enhanced Systemic Immune and Memory Response." Advanced Functional Materials, 26(35), 6454-6461. (IF = 15.621)

36. Q. Hu, Qian, C., Sun, W., Wang, J., Chen, Z., Bomba H. N., Xin, H., Shen, Q., and Gu, Z. (2016) Advanced Materials, 28(43), 9573-9580. (IF = 25.809)

37. H. Ji, K. Dong, Z. Yan, C. Ding, Z. Chen, J. Ren and X. Qu (2016). "Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection." Small, 45, 6200-6206. (IF = 10.856)

38. Z. Wang, K. Dong, Z. Liu, Y. Zhang, Z. Chen, H. Sun, J. Ren and X. Qu (2017). "Activation of biologically relevant levels of reactive oxygen species by Au/g-C3N4 hybrid nanozyme for bacteria killing and wound disinfection." Biomaterials 113, 145-157. (IF = 10.273)

39. Z. Wang, Y. Zhang, E. Ju, Z. Liu, F. Cao, Z. Chen, J. Ren and X. Qu (2018). "Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors." Nature Communications,9(1), 3334. (IF=11.878)

40. Wang, J.; Ye, Y.; Yu, J.; Kahkoska, A. R.; Zhang, X.; Wang, C.; Sun, W.; Corder, R. D.; Z. Chen.; Khan, S. A.; Buse, J. B.; Gu, Z (2018). “Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery.” ACS Nano, 12, 2466-2473. (IF = 13.903)

41. Wang, J., J. Yu, Y. Zhang, X. Zhang, A. R. Kahkoska, G. Z. Chen, Wang, W. Sun, L. Cai, Z. Chen, C. Qian, Q. Shen, A. Khademhosseini, J. B. Buse and Z. Gu (2019). "Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs." Science Advances, 5(7), eaaw4357. (IF = 12.804)

其他

课题组常年招收具有化学、分子生物学、材料学等背景相关专业的硕士、博士、博士后,待遇优厚。有意向者请发送简历至邮箱:chenzw@fzu.edu.cn或zhaowei_chen@126


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