姓    名: 林子俺
性    别:

 

职    称: 研究员
学    历: 博士
职    务: 教授/博导
电    话:
专    业: 分析化学
电子邮件: zianlin@fzu.edu.cn; zianlin@163.com
研究方向: 生物分离分析;材料分析化学

教育工作经历
博士、研究员、博导

教育背景:
1995.9-1998.7 福州大学化学系 工业分析专业
2002.9-2004.7 福州大学化学化工学院 分析化学(硕士)
2004.9-2007.7 福州大学化学化工学院 分析化学(直接攻读博士)
工作经历:
2007.7-2009.6 南开大学化学学院 博士后 (合作导师:张玉奎院士)
2009.7-至今 福州大学化学化工学院/食品安全分析与检测教育部重点实验室
2014.9-2015.8期间 香港浸会大学理学院/化学系 博士后 (合作导师 蔡宗苇教授)

2010.12年 晋升副研究员;
2015年6月 破格获博士生导师资格;
2016年7月 晋升研究员;


 

教学简介
目前主要承担的教学任务:
主讲研究生课程:
《高等分析化学》;
《食品安全》;
《色谱新技术及应用》
《现代药物分析》;
《药学综合实验》

主讲本科生课程:
《分析化学与仪器分析》;
《分析化学基础实验》;
《仪器分析实验》;
《教授科研导论讲座》;
 

科研简介
林子俺,男,1977年1月出生,博士,研究员,博士生导师,福州大学化学学院药物分析硕士学位点负责人,福建省食品安全专家库成员,福建省食品安全促进会专家库成员,国家自然科学基金委函评专家,教育部学位中心函评专家。2007年7月毕业于福州大学化学学院分析化学专业,获理学博士学位。2007.7-2009.6在南开大学化学学院从事博士后研究。2009年7月起,就职于福州大学化学学院并加入“食品安全分析与检测教育部重点实验室”科研团队。2014.9-2015.8期间在香港浸会大学理学院化学系从事博士后研究。2012年获福建省科技进步奖二等奖(排名第六),2016年获中国分析测试协会科学技术(CAIA奖)一等奖(排名第二),2017年入选福建省高等学校新世纪优秀人才支持计划,同年获福州大学青年教师励志奖。近年来主持国家自然科学基金(21675025、21375018、21005018)、教育部博士点基金(新教师类 (20103514120002)、福建省自然科学基金(2010J01039,2014J01042)等多项科研项目。现主要从事(1)新型色谱整体材料、磁性纳米材料、仿生识别材料的制备及其在蛋白组学中的应用研究;(2)面向蛋白质组学的色谱/电泳/电色谱-质谱联用技术等方面的研究。多次应邀担任ACS Nano, Nano Letter., J. Am. Chem. Soc., Small, Anal. Chem, Chem. Commun,等20多个国际权威刊物审稿人。至今,以第一或通讯作者身份在Adv.Mater., Mass Spectrom. Rev., Anal. Chem., Chem. Commun., J. Mater. Chem., Biosens. Bioelectron., ACS Applied Materials& interfaces, J. Chromatogr. A, Analyst等国际高水平刊物上发表SCI论文50余篇,申请国家发明专利12项(现已授权6项),论文被SCI 引用共计1300余次,相关研究成果多次被期刊作为研究亮点进行了专题报道和评述。
Research ID
http://www.researcherid.com/rid/C-3506-2011
 

社会兼职
1.国家自然科学基金委函评专家;
2.教育部学位中心函评专家;
3.福建省食品安全委员会专家库成员;
4.福建省食品安全促进会专家组成员;
5.担任J AM CHEM SOC.,ACS Nano,Nano Letter., Small., Anal.Chem.,Chem. Commun.,ACS Macro Letters, J. Mater. Chem (B)., Nanoscale, ACS. Applied Materials&Interfaces., Biosens. Bioelectron., Biomacromolecules, Journal of Chromatography A, Analyst, Langmuir, J. Mol. Recognit. Talanta, RSC Advances, Journal of Separation Science, :Rapid Commun Mass Spectrom.,Recent Patents on Nanotechnology,Separation Science & Technology, Current Pharmaceutical Analysis,Analytical method,《高等学校化学学报》(英文版),《环境化学》等国内外权威刊物评审人。
6.药物分析硕士学位点负责人
7.中国化学会会员
 

科研项目
主持科研项目:
1.国家自然科学基金:(No:21675025)(2017.1-2020.12)(在研)
2.国家自然科学基金:(No:21375018)(2014.1-2017.12)(在研)
3.国家自然科学基金:(No:21005018)(2011.1-2013.12) (结题)
4.福建省自然科学基金(面上项目)(No:2014J1042)(2014.1-2016.12)(在研)
5.教育部博士点(新教师)基金:(20103514120002)(2011.1-2013.12)(结题)
6.国家基础科学人才培养基金提高项目(J2013-007)(在研)
7.中国博士后基金:(No:20070420688)(2007-2009)(结题)
8.福建省自然科学基金(面上项目):(2010.6-2013.1)(结题)
9.福建省教育厅A类科技项目:(N0:JA10030)(2010.8-2012.12)(结题)
10.福州大学科技发展基金:(No:2010-XQ-07)(2010-2012) (结题)
11.福州大学引进人才启动基金:(No:0460022233)(2009-2012) (结题)
12.横向课题:(NO:2016N2016) (2016.5-2018.12)(在研)
13.横向课题:(NO:2016S3003)(2016.5-2019.5)(在研)


参与科研项目:
1.国家科技部“863”计划:(No:2006AA09Z161)(2006-2009)
2.福建省重点科技项目:(No:2006Y0023)(2006-2009)
3.国家自然科学基金:(No:21075016)(2011.1-2013.12)
4.国家自然科学基金:(No:21075017)(2011.1-2013.12)
 

代表性论文
仅列出第一作者或通讯作者(*)
1. Zian Lin, Zenghong Xie*, Haixia Lv, Xucong Lin, Xiaoping Wu, Guonan Chen*; On column coaxial flow chemiluminescence detection of underivated amino acids with pressurized capillary electrochromatography. Anal. Chem, 2006, 78, 5322-5328.
2. Zian Lin, Xiaoping Wu, Xucong Lin, Zenghong Xie*; End-column chemiluminescence detection for pressurized capillary electrochromatographic analysis of norepinephrine and epinephrine. J. Chromatogr. A 2007, 1170, 118-121.
3. Zian Lin, Zenghong Xie*, Jian Lin, Xucong Lin, Xiaoping Wu; Evaluation of band broadening in chemiluminescence detection coupled to pressurized capillary electrochromatography with an off-column coaxial flow interface. Electrophoresis 2008, 29, 401-409.
4. Zian Lin*, Zenghong Xie; Direct determination of amino acids by pressurized capillary electrochromatography with chemiluminescence detection. J. Sep. Sci, 2008, 31, 2852-2859.
5. Zian Lin, Fan Yang, Xiwen He*, Xiaomiao Zhao, Yukui Zhang*; Preparation and evaluation of a macroporous molecularly imprinted hybrid silica monolithic column for selective recognition of proteins by high performance liquid chromatography J. Chromatogr. A 2009, 1216, 8612-8622.
6. Zian Lin, Fan Yang, Xiwen He*, Yukui Zhang*; Organic-inorganic hybrid silica as supporting matrices for specific recognition of bovine hemoglobin via covalent immobilization. J. Sep. Sci, 2009, 32, 3980-3987.
7. Zian Lin, Jianhua Zhang, Huimin Cui, Lan Zhang, Guonan Chen*; Determination of aromatic amines in environmental water sample by hollow fiber-liquid phase microextraction and microemulsion electrokinetic chromatography. J. Chromatogr. A 2010, 1217, 4507-4510.
8. Tiemei Li, Zian Lin*, Guonan Chen, Lan Zhang*; Controllable Preferential-etching Synthesis of ZnO Nanotubes Array on SiO2 Substrate for Solid-phase Microextraction. Analyst, 2010, 135, 2694-2699
9. Zian Lin, Jianhua Zhang, Huimin Cui, Lan Zhang, Guonan Chen*; Determination of six phthalate esters in soil by microemulsion electrokinetic chromatography coupled with accelerated solvent extraction. J. Sep. Sci, 2010, 33, 3717-3725.
10. Zian Lin*, Jiangnan Zheng, Feng Lin, Lan Zhang, Guonan Chen*; Synthesis of Magnetic Nanoparticles with Immobilized Aminophenylboronic Acid for Selective Separation and Enrichment of Glycoproteins. J. Mater. Chem., 2011, 21, 518-524.
11. Zian Lin*, Jilei Pang, Yao Lin, Hui Huang, Zongwei Cai, Lan Zhang*, Guonan Chen; Preparation and evaluation of phenylboronate affinity monolith for selective capture of glycoproteins by capillary liquid chromatography. Analyst, 2011, 136(16),3281-3288.
12. Zian Lin*, Jilei Pang, Huanghao Yang, Zongwei Cai, Lan Zhang*, Guonan Chen; One-pot synthesis of organic-inorganic hybrid affinity monolithic column for specific capture of glycoproteins. Chem. Commun., 2011, 47 (34), 9675-9677.(TOP 20 articles published on the same topic since its publication)
13. Zongbao Chen, Zian Lin*, Yan Cai, and Lan Zhang*. Analysis of plant hormones by microemulsion electrokinetic capillary chromatography coupled with on-line large volume sample stacking. Analyst, 2012,137,1723-1729.
14. Zian Lin*, Hui Huang, Xiaobo Sun, Yao Lin, Lan Zhang, Guonan Chen.Monolithic column based on a poly(glycidyl methacrylate -co-4-vinylphenylboronic acid-co-ethylene dimethacrylate) copolymer for capillary liquid chromatography of small molecules and proteins.J. Chromatogr. A 2012,1246,90-97.
15. Zian Lin,* Jiangnan Zheng, Zhiwei Xia, Huanghao Yang, Lan Zhang,* Guonan Chen. One-pot synthesis of phenylboronic acid-functionalized core-shell magnetic nanoparticles for selective enrichment of glycoproteins. RSC Adv., 2012,2,5062-5065.
16. Hui Huang, Zian Lin*, Yao Lin, Xiaobo Sun, Yanyan, Xie, Lan Zhang, Guonan Chen. Preparation and evaluation of poly(4-vinylphenylboronic acid-co-pentaerythritol triacrylate) monolithic column for capillary liquid chromatography of small molecules and proteins.J. Chromatogr. A 2012, 1251,82-90.
17. Zian Lin*, Zhiwei Xia, Jiangnan Zheng, Duo Zheng, Lan Zhang, Huanghao Yang* and Guonan Chen. Synthesis of uniformly sized molecularly imprinted polymer-coated silica nanoparticles for specific recognition and enrichment of lysozyme. J. Mater. Chem.,2012,22,17914-17922.
18.Zian Lin*, Hui Huang, Shihua Li, Juan Wang, Xiaoqing Tan, Lan Zhang, Guonan Chen*. Preparation and evaluation of phenylboronic acid-silica hybrid monolithic column with “one-pot” approach for mixed-mode capillary liquid chromatography of biomolecules.J. Chromatogr.A 2013,1271,115-123.
19. Zian Lin*, Xiaobo Sun, Yao Lin, Guonan Chen*. Highly sensitive analysis of four hemeproteins by dynamically-coated capillary electrophoresis with chemiluminescence detector using an off-column coaxial flow interface. Analyst, 2013, 138 (8), 2269 – 2278.
20. Zian Lin,* Yao Lin, Xiaobo Sun, Huanghao Yang, Lan Zhang,* and Guonan Chen. One-Pot Preparation of a Molecularly Imprinted Hybrid Monolithic Capillary Column for Selective Recognition and Enrichment of Lysozyme.J. Chromatogr.A 2013,1284,8-16.
21.Zhiwei Xia, Zian Lin,* Yun Xiao, Ling Wang, Lan Zhang, Huanghao Yang* and Guonan Chen. Mussel-inspired synthesis of polydopamine-coated molecularly imprinted silica nanoparticles for protein recognition and separation. Biosens. Bioelectron. 2013,47,120-126.
22.Jintian Cheng, Xiadi Chen, Yu He, Zongbao Chen, Zian Lin*, Lan Zhang*Preparation and evaluation of a hydrophilic poly(2-hydroxyethyl methacrylate-co-N,N-methylene bisacrylamide) monolithic column for pressurized capillary electrochromatography.Electrophoresis 2013, 34(8), 1189-1196.
23.Cheng Zheng, Xiaolong Zhang, Wei Liu, Bo Liu, Zian Lin*, Huanghao Yang* and Guonan Chen;A selective artificial enzyme inhibitor based on nanoparticle-enzyme interactions and molecular imprinting. Adv. Mater, 2013, 25(41), 5922-5927.
24.Zian Lin*, Xiaobo Sun, Wenli Hu, Yuqing Yin, Guonan Chen*
Sensitive determination of positional isomers of benzenediols in human urine by boronate affinity capillary electrophoresis with chemiluminescence detection.Electrophoresis 2014, 35, 993–999.
25.Zian Lin,* Zhiwei Xia, Lixiang Sun, Ruifang Yu, Huanghao Yang,* Guonan Chen.Synthesis of boronic acid-functionalized molecularly imprinted silica nanoparticle composites for glycoprotein recognition and enrichment.J. Mater. Chem. B, 2014, 2 (6), 637 - 643.(hot article)
26.Zian Lin* et al; Preparation of boronate-functionalized molecularly imprinted monolithic column with polydopamine coating for glycoprotein recognition and enrichment. J. Chromatogr.A. 2013,1319,141-147 (Featured by NewsRx as hot article)
27. Zian Lin* et al; Facile Synthesis of Enzyme-Inorganic Hybrid Nanoflowers in Aqueous Media and Their Application in Enzymatic RSC Adv., 2014, 4 (27), 13888 - 13891
28.Jiangnan Zheng, Yun Xiao, Ling Wang, Zian Lin,* Huanghao Yang, Lan Zhang,* Guonan Chen. Click synthesis of glucose-functionalized hydrophilic magnetic mesoporous nanoparticles for highly selective enrichment of glycopeptides and glycans J. Chromatogr. A 2014, 1358, 29-38.
29.Zian Lin* et al;Polymer monolithic capillary column fabricated by using monodisperse iron oxide nanocrystal template to enhance the electrochromatographic separation of small molecules. Electrophoresis 2014, 35(14), 1947-1955.
30. Zian Lin*, Xiaoqing Tan, Ruifang Yu, Jiashi Lin, Xiaofei Yin, Juan Wang, Lan Zhang, Huanghao Yang. One-pot preparation of glutathione-silica hybrid monolith for mixed-mode capillary liquid chromatography based on “thiol-ene” click chemistry. J. Chromatogr. A 2014, 1355, 228-237.
31. Zhiming Yan, Jiangnan Zheng, Jinfeng Chen, Ping Tong, Zian Lin*, Lan Zhang*, Preparation and evaluation of silica-UIO-66 composite as liquid chromatographic stationary phase for fast and efficient separation. J. Chromatogr. A 2014,1366,45-53.
32. Zian Lin*, Yun Xiao, Yuqing, Yin, Wenli Hu, Wei Liu, Lan Zhang, Huanghao Yang*. Facile Synthesis of Enzyme-Inorganic Hybrid Nanoflowers and its Application as a Colorimetric Platform for Visual Detection of Hydrogen Peroxide and Phenol. ACS Appl. Mater. Interfaces, 2014,6,10775–10782.
33. Zian Lin* et al. One-pot synthesis of polymer monolithic column by combination of free radical polymerization and azide-alkyne cycloaddition “click” reaction and its application in capillary liquid chromatography.RSC Adv., 2015, 5, 9828–9836.
34. Zian Lin* et al. One-pot synthesis of CuFe2O4 magnetic nanocrystal clusters for highly specific separation of histidine-rich proteins. J. Mater. Chem. B, 2014,2,6207–6214.
35.Zian Lin* et al.Incorporation of graphene oxide nanosheets into boronate-functionalized polymeric monolith to enhance the electrochromatographic separation of small molecules. Electrophoresis, 2015, 36(4), 596-606.
36.Zian Lin*, Ruifang Yu, Wenli Hu, Jiangnan Zheng, Hongzhi Zhao and Zongwei Cai.* Preparation of a poly (3'-azido-3'-deoxythymidine-co- popargylmethacrylate-co-pentaerythritol triacrylate) monolithic column by in situ polymerization and click reaction for capillary liquid chromatography of small molecules and proteins, Analyst, 2015, DOI: 10.1039/C5AN00409H.
37.Yuqing Yin, Yun Xiao, Guo Lin, Qi Xiao, Zian Lin*, Zongwei Cai. Enzyme-inorganic hybrid nanoflowers based immobilized enzyme reactor with enhanced enzymatic activity. J. Mater. Chem. B, 2015, 3, 2295-2300 (Highlighted on back cover).
38.Zian Lin* et al; Preparation of magnetic metal-organic framework nanocomposites for highly specific separation of histidine-rich proteins. J. Mater. Chem. B, 2015, 3, 2185 – 2191.
39. Zhiming Yan, Wenmin Zhang, Jia Gao, Yifen Lin, Zian, Lin*, Lan Zhang*. Reverse-phase high performance liquid chromatography separation of positional isomers on the MIL-53(Fe) packed column. RSC Adv., 2015, 5, 40094-40102.
40. Zian Lin * and Zongwei Cai* et al., CuFe2O4 magnetic nanocrystal clusters as a matrix for the analysis of small molecules by negative ion MALDI-TOF MS. Analyst, 2015, DOI: 10.1039/C5AN00625B.
41.Zian Lin and and Zongwei Cai* et al., Magnetic metal-organic framework nanocomposites for enrichment and direct detection of small molecules by negative-ion matrix-assisted laser desorption/Ionization time-of-flight mass spectrometry. Chem. Commun., 2015,51, 8785-8788.
42. Wei Liu, Jiangnan Zheng, Shihua Li, Ruirui Wang, Zian Lin* and Huanghao Yang* Aluminium glycinate functionalized silica nanoparticles for highly specific separation of phosphoproteins.J. Mater. Chem. B, 2015, 3(31), 6528- 6535.
43. Zian Lin, Jiangnan Zheng, Guo Lin, Zhi Tang, Xueqing Yang, and Zongwei Cai*. Negative Ion Laser Desorption/Ionization Time-of-Flight Mass Spectrometric Analysis of Small Molecules Using Graphitic Carbon Nitride Nanosheet Matrix. Anal. Chem., 2015, 87 (15), 8005–8012.
44.Shihua Li, Ling Wang, Sen Zhao, Jinjin Lin, Jiangnan Zheng, Lan Zhang and Zian Lin* Preparation of phenyl group-functionalized magnetic mesoporous silica microspheres for fast separation and selective enrichment of peptides. J. Sep. Sci. 2015, 38(22), 3954-3960.
45. Zian Lin* et al. Click synthesis of boronic acid- functionalized molecularly imprinted silica nanoparticles with polydopamine coating for enrichment of trace glycoprotein.Anal.Method. 2015, 7, 10026 - 10031.
46. Zian Lin* et al. Protein-Metal Organic Framework Hybrid Composites with Intrinsic Peroxidase-like Activity as a Colorimetric Biosensing Platform. ACS Appl. Mater. Interfaces, 2016, 8 (42), pp 29052–29061
47.Zian Lin* et al Recent advances in negative ion surface-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of small molecules. Mass Spectrom. Rev. 2017 Accepted
48 Yanting He, Wei Liu, Qi Xiao, Guo Lin, Lei Chen, Chenling Gao, Jianlin Wu,and Zian Lin*. Facile synthesis of Ti4+-immobilized affinity silica nanoparticles for highly selective enrichment of intact phosphoproteins. J. Sep. Sci. DOI: 10.1002/jssc.201601048
49.Guo Lin, Chaohong Gao, Qiong Zheng, Zhixian Lei, Zian Lin,* Huanghao Yang and Zongwei Cai* Room-temperature synthesis of core-shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins. Chem. Commun.,2017, 53, 3649-3652 (Highlighted on inside back cover)
50. Zian Lin* et al. One-pot preparation of mercaptotetrazole-silica hybrid monolith based on "thiol-ene" click chemistry for mixed-mode capillary liquid chromatography of small molecules. J. Sep. Sci. DOI: 10.1002/jssc.201700220
 

获奖情况
1.福建省科学技术进步奖 二等奖 2012.(排名第六)
2.中国分析测试协会科学技术奖(CAIA奖)一等奖 2016.(排名第二)
3.2012年,指导1名硕士研究生获得校优秀硕士毕业论文奖;
4.2013年,指导1名硕士研究生获得校优秀硕士毕业论文奖;
5.2014年,指导2名硕士研究生获得校优秀硕士毕业论文奖;
6.2015年,指导2名硕士研究生获得校优秀硕士毕业论文奖,其中1人获省优秀硕士论文奖;
7.2015年,指导国家基础科学人才基金能力提高项目,一等奖;


 

其他
 申请国家发明专利:
(1)一种有机-无机杂化毛细管整体柱制备方法(ZL201110085266.7)已授权
(2)一锅合成的苯硼酸聚合物磁性纳米复合材料及制备方法(ZL201210000137.8)已授权
(3)有机-无机杂化蛋白质分子印迹毛细管整体柱 (201210110319.0)公示
(4)一种亲水磁性介孔微球及其制备方法与应用(ZL201310163661.1) 已授权
(5)一种蛋白质掺杂的有机-无机杂化花状纳米材料及其制备方法(201310170334.9)公示
(6)一种疏水磁性介孔微球及其制备方法和应用(ZL201410034003.7) 已授权
(7)一种基于Cu(I)点击的聚合物基质毛细管整体柱及其制备方法(201410132570.6)已授权
(8)一种核苷聚合物基质的毛细管整体柱及其制备方法和应用 (201410541150.3) 已授权
(9)一种磁性共价有机骨架纳米复合材料及制备方法和应用 (201610246124.7)公示
(10)一种双功能亲和有机聚合基质毛细管整体柱的制备方法 (2017101304648)公示
(11) 巯基苯并芘磺酸型有机-无机杂化整体柱及制备和应用 (201710206235X)申请
(12)一种核壳结构的共价有机骨架复合微球的制备方法 (2017103889410) 申请
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