(7月28日)有机合成化学的学术报告
新闻类型:学术活动  阅读次数:  发布时间:2014-07-10

 

 

报告题目:Electrophilic Cyclization of Alkynes–Facile Approaches to Heterocycles and Carbocycles 
报告人: Dr. Yu CHEN
Queens College, City University of New York
报告时间:2014年7月28日上午10:00
报告地点:化学化工学院学术报告厅 嘉锡楼413
邀请单位:福州大学 化学学院 
学术报告内容简介:
 
The Chen group at Queens College–the City University of New York is currently working on methodology development for the synthesis of biologically interesting heterocyclic and carbocyclic compounds. Palladium and gold-catalyzed as well as iodine monochloride-induced intramolecular electrophilic cyclization of functionally substituted alkynes will be discussed. These regioselective annulations represent new and efficient synthetic approaches to a variety of carbocycles and heterocycles including isoxazoles, isoquinolines, indenones, and dibenzoannulen-5-ones which cover applications in a broad spectrum of fields including synthetic and medicinal chemistry, and the material sciences.
 
学术报告人的简历及研究经历: 
Yu Chen, Ph.D.
Department of Chemistry and Biochemistry                     Phone: 718-997-4132
Queens College & the Graduate Center                     Fax: 718-997-5531
City University of New York                             Email: yu.chen1@qc.cuny.edu
65-30 Kissena Blvd., Flushing, NY, 11367, USA        Web: http://chem.qc.cuny.edu/~ychen/YuChen.htm
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EDUCATION AND TRAINING 
Postdoctoral Researcher Iowa State University, Chemistry Department 
Supervisor: Prof. Richard C. Larock
Ph.D. University of Toronto, Chemistry Department
Supervisor: Prof. Andrei K. Yudin
M.Sc. Nankai University, Chemistry Department
Supervisor: Prof. Licheng Song
B.Sc. Nankai University, Chemistry Department
 
RESEARCH EXPERIENCES
Palladium chemistry, gold chemistry, aryne chemistry and heterocyclic chemistry
Asymmetric catalysis 
Combinatorial chemistry and microwave synthesis
Synthesis and characterization of air-sensitive organometallic complexes
Process chemistry and multi-step synthesis
SELECTED PUBLICATIONS
1) Chen, Y.;* Huang, C.; Liu, X.; Perl, E.; Chen, Z.; Namgung, J.; Subramaniam, G.; Zhang, G.; Hersh, W. H. “Synthesis of Dibenzocyclohepten-5-ones by Electrophilic Iodocyclization of 1-([1,1'-Biphenyl]-2-yl)-alkynones”, J. Org. Chem. 2014, 79, 3452-3464. 
2) Chen, Y.;* Liu, X.; Lee, M.; Huang, C.; Inoyatov, I.; Chen, Z.; Perl, A. C.; Hersh, W. H. “ICl-Induced Intramolecular Electrophilic Cyclization of 1-(4'-Methoxy-[1,1'-biphenyl]-2-yl)-alkynones—A Facile Approach to Spiroconjugated Molecules”, Chem. Eur. J. 2013, 19, 9795-9799. 
3) Long, Y.; She, Z.; Liu, X.; Chen, Y.* “Synthesis of 1-Aminoisoquinolines by Gold(III)-Mediated Domino Reactions from 2-Alkynylbenzamides and Ammonium Acetate”, J. Org. Chem. 2013, 78, 2579-2588. 
4) Yang, D.; Burugupalli, S.; Daniel, D.; Chen, Y.* “Microwave-Assisted One-Pot Synthesis of Isoquinolines, Furopyridines and Thienopyridines by Palladium-Catalyzed Sequential Coupling-Imination-Annulation of 2-Bromoarylaldehydes with Terminal Acetylenes and Ammonium Acetate”, J. Org. Chem. 2012, 77, 4466-4472. [highlighted in SYNFACTS “One-Pot Pd-Catalyzed Synthesis of Isoquinolines and Furo/Thienopyridines.” SYNFACTS 2012, 8, 830.] 
5) She, Z.; Niu, D.; Chen, L.; Gunawan, M. A.; Shanja, X.; Hersh, W. H.; Chen, Y.* “Synthesis of Trisubstituted Isoxazoles by Palladium(II)-Catalyzed Cascade Cyclization-Alkenylation of 2-Alkyn-1-one O-Methyl Oximes”, J. Org. Chem. 2012, 77, 3627−3633. 
 
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