(6月29日) 自然和人工体系中的功能核酸一一重要的科学发现和一些鲜为人知的故事
新闻类型:学术活动  阅读次数:  发布时间:2017-06-27

 

 

讲座题目: 自然和人工体系中的功能核酸一一重要的科学发现和一些鲜为人知的故事

讲授人: Yingfu Li(加拿大马克马斯特大学(McMaster University)生物化学及药学系终生教授)

时间: 2017年6月29日 上午9点(星期四)

地点: 福州大学嘉锡楼413

邀请单位: 福州大学肿瘤转移的预防与预警研究所

个人简介:

Yingfu Li was born and raised in Anhui, China. He received his BSc in chemistry at Anhui University in 1983, and his MSc in applied chemistry at Beijing Agriculture University in 1989. He moved to Canada in 1992, and in 1997, he graduated with a PhD in chemistry and biochemistry at Simon Fraser University under the supervision of Professor Dipankar Sen. His doctoral study led to the discovery of one of the earliest DNA molecules with catalytic ability. He achieved this feat through a powerful test-tube evolution technique known as in vitro selection. This work won him Governor General of Canada Gold Medal (1998) and a Doctoral Prize from the Natural Sciences and Engineering Research Council of Canada (1998).  He received a Medical Research Council of Canada postdoctoral fellow in 1997 and spent the next two years in the laboratory of Ronald Breaker at Yale University to study artificial evolution using DNA as the model system. Through test-tube evolution he derived a series of nucleic acid enzymes that are capable of modifying DNA using chemical reactions that are carried out in cells by protein enzymes. In 1999, he joined McMaster University as an assistant professor in the Department of Biochemistry and Biomedical Sciences and the Department of Chemistry and Chemical Biology, was promoted to the rank of associate professor in 2005 and full professor in 2010. At McMaster, he has established a research group to take advantage of the powerful test-tube evolution technique to develop artificial DNA and RNA molecules that can be used to address fundamental biochemical and evolutionary questions or can be utilized for wide-ranging applications.  He has published extensively in the fields of chemistry, biochemistry and molecular evolution of nucleic acids. He has published 160 research and review articles, 15 book chapters, edited 1 book, and filed 22 patents. He also serves as an associate editor of Journal of Molecular Evolution, a Springer journal. He has received several recognitions, including Canada Research Chair, New Investigator Award from the Canadian Institute of Health Research (CIHR), Premier Research Excellent Award from Ontario Government, W. A. McBryde Medal from Canadian Society of Chemistry and Outstanding Young Scientist from National Science Foundation of China.

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