（01月15日）有机小分子的按需自动化合

报告时间：2026年01月15日上午 09:00

报告地点：福州大学卢嘉锡楼413

报告人：吴杰教授，新加坡国立大学

主持人：刘晨光 研究员

组织单位：有机合成与功能研究所

联系人：刘晨光

联系方式:15606948590

报告人简介

Jie obtained his PhD in 2012 with Prof. James S. Panek at Boston University working on natural product total synthesis. In his postdoc research at MIT with Prof. Timothy Jamison and Prof. Alan Hatton, Jie has been exposed to the hard core of continuous flow chemistry. Since joining NUS in July 2015, his research group focuses on new synthetic methodology development using photocatalysis assisted by advanced flow technologies. His group is also interested in the development of advanced flow technologies for on-demand and automated synthesis of functionalized organic molecules. In July 2021, Jie was promoted to tenured associate professor. His research group has published more than 100 papers in these research areas, with more than 10 filed patents. Jie is a recipient of Dean’s Chair Professor (2023), Tokyo Chemical Industry-SNIC Industry Award in Synthetic Chemistry (2021), NUS Young Research Award (2021), Yong Scientist Award (2020), Asian Core Program Lectureship Award (2017-2022), Thieme Chemistry Journal Award (2019), and NUS Chemistry Department Young Chemist Award (2018).

报告内容简介：“Button-push” automated synthesis of complex molecules represents one of the future goals for organic synthesis. In this talk, I will present some of our recent efforts towards this goal employing advanced flow reactors. A “stop-flow” micro-tubing (SFMT) reactor platform was invented,[1] which is especially suitable for gas involved reactions under light irradiations. A high-speed circulation flow reactor has been developed for heterogeneous photocatalysis.[2-4] An SPS-flow system was employed to enable automated API synthesis that can deliver analogues in an on demand and button-push fashion.[5,6] In this talk, I will also introduce the NUS chemistry self-finance MSc programs.

Figure 1: On-demand automated synthesis

References

[1] F. Xue, H. Deng, C. Xue, D. K. B. Mohamed, K. Y. Tang, J. Wu, Chem. Sci. 2017, 8, 3623.

[2] Liu, C.; Song, L.; Liu, Q.; Chen, W.; Xu, J.; Wang, M.; Zhang, Y.; Tan, T. W.; Lei, Z.; Cheng, L.; Khan, S. A.; Wu, J. Org. Process Res. Dev. 2024, 28, 1964-1970.

[3] Liu, T.; Li, T.; Tea, Z. Y.; Wang, C.; Shen, T.; Lei, Z.; Chen, X.; Zhang, W.; Wu, J. Nat. Chem. 2024, 16, 1705-1714.

[3] Shi, Y.; Hai, X.; Cheng, L.; Du, H.; Yu, X.; Ang, H. T.; Wu, J.; Chen, J.; Wang, G.; Lu, J.; Wu, J. Nat. Catal. 2025, DOI: 10.1038/s41929-025-01450-2.

[4] C. Liu, J. Xie, W. Wu, M. Wang, W. Chen, S. B. Idres, J. Rong, L.-W. Deng, S. A. Khan, J. Wu, Nat. Chem. 2021, 13, 451.

[5] Manuscript submitted.