嘉锡科学讲座014期：Expanding Axial Chirality through N-Heterocyclic Carbene Catalysis

报告时间：2026年10月21日10:00

报告地点：福州大学化学学院嘉锡楼413

组织单位：有机合成与功能福建省高校重点实验室

联系人及方式：杨凯 18059870235

报告人简介：A. T. Biju received his M. Sc. from Sacred Heart College Thevara (affiliated to MG University, Kerala, India) and Ph.D. under the guidance of late Dr. Vijay Nair at the CSIR-NIIST (Formerly RRL), Trivandrum, India. Subsequently, he has been a post-doctoral fellow with Prof. Tien-Yau Luh at the National Taiwan University, Taipei and an Alexander von Humboldt fellow with Prof. Frank Glorius at the Universität Münster, Germany. In June 2011, he began his independent research career at the CSIR-National Chemical Laboratory, Pune. In June 2017, he moved to the Department of Organic Chemistry, Indian Institute of Science, Bangalore, where he is a professor presently. His research focuses on developing strategies using N-heterocyclic carbene (NHC) organocatalysis, and strain-release driven reactions of arynes, donor–acceptor cyclopropanes and bicyclobutanes. He is presently the Associate Editor of Synthesis.

报告内容简介：Organocatalysis using N-heterocyclic carbene (NHCs) has been widely utilized for the polarity reversal of aldehydes (umpolung). Although NHC catalysis is well demonstrated for the enantioselective synthesis of target molecules, related application to the synthesis of axially chiral molecules is limited (especially the heteroatom-containing axis). We have recently reported the NHC-catalyzed atroposelective synthesis of C-N axially chiral N-aryl succinimides, phthalimides/maleimides, pyridinones, N-N axially chiral 3-amino quinazolinones, indoles and pyrroles as well as C-O axially chiral diarylethers. In addition, precise control over S(VI) and P(V)-stereogenic centers have recently be achieved by the enantioselective synthesis of N-acyl cyclic sulfonimidamides and phosphacycles. The details of these works will be discussed.