2021-至今 浙江大学药学学院，兼职教授（顾臻教授团队）。

2020-至今 福州大学化学学院，教授、博导 （杨黄浩教授团队）。

2019-2020 加州大学洛杉矶分校，博士后（导师：顾臻教授）。

2017-2019 阿贡国家实验室，博士后（导师：Elena A. Rozhkova, Scientist）。

2016-2017 北卡罗莱纳州立大学，博士后（导师：顾臻教授）。

2010-2016 中科院长春应化所，博士研究生(导师：任劲松研究员 and 曲晓刚研究员)。

2006-2010 西北工业大学，工学学士。

1. 福州大学“闽江学者”特聘教授科研启动基金(2020-2023；主持)。

2. 国家海外高层次人才引进启动基金（2021-2025；主持）。

3. 福建省海外高层次人才引进启动基金（2021-2025；主持）。

4. 国家重点研发计划纳米科技重点专项“靶向肿瘤转移节点分子的多模块可编程纳米药物”项目，承担其中课题二的子课题(2021-2026；主持)。

5. 国家自然科学基金青年项目（2022-2024；主持）。

6. 国家自然科学基金面上项目（2023-2026；主持）。

7. 国家自然科学金创新群体项目（2025-2029；项目骨干）。

8. 国家自然科学基金面上项目（2026-2029；主持）。

1. 国家海外高层才人才青年项目获得者

2. 闽江学者特聘教授

3. 福建省海外高层次人才(B)

4. 福建省高层次人才（C）

5. 中科院优秀博士学位论文

6. 中科院朱李月华优秀博士生奖

7. 博士研究生国家奖学金

Google Scholar: https://scholar.google.com/citations?user=3SyRXJAAAAAJ&hl=en

(I) Artificial synthetic cells and protocells built upon chemistry, synthetic biology and micro-/nanomaterials for theranostic, biosensing, bioenergy conversion and life-of-origin researches.

(1) Chen, Z.; Wang, J.; Sun, W.; Archibong, E.; Kahkoska, A. R.; Zhang, X.; Lu, Y.; Ligler, F. S.; Buse, J. B.; Gu, Z.* Synthetic beta cells for fusion-mediated dynamic insulin secretion. Nat. Chem. Biol. 2018, 14, 86-93.

(2) Chen, Z.; Zhang, H.; Guo, P.; Zhang, J.; Tira, G.; Kim, Y. J.; Wu, Y. A.; Liu, Y.; Wen, J.; Rajh, T.; Niklas, J.; Poluektov, O. G.; Laible, P. D.; Rozhkova, E. A.* Semi-artificial Photosynthetic CO2 Reduction through Purple Membrane Re-engineering with Semiconductor. J. Am. Chem. Soc. 2019, 141, 11811-11815.

(3) Chen, Z.; De Queiros Silveira, G.; Ma, X.; Xie, Y.; Wu, Y. A.; Barry, E.; Rajh, T.; Fry, H. C.; Laible, P. D.; Rozhkova, E. A.* Light-Gated Synthetic Protocells for Plasmon-Enhanced Chemiosmotic Gradient Generation and ATP Synthesis. Angew. Chem. Int. Ed. 2019, 58, 4896-4900.

(4) Chen, Z.*; Wen, D.; Gu, Z.* Cargo-encapsulated cells for drug delivery. Sci. China Life Sci. 2020, 63, 599-601.

(5) Han, X.; Li, H.; Zhou, D.; Chen, Z.*; Gu, Z.* Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics. Acc. Chem. Res. 2020, 53, 2521-2533.

(6) Chen, Z.; Wang, Z.; Gu, Z.* Bioinspired and Biomimetic Nanomedicines. Acc. Chem. Res. 2019, 52, 1255-1264.

(7) Chen, Z.; Hu, Q.; Gu, Z.* Leveraging Engineering of Cells for Drug Delivery. Acc. Chem. Res. 2018, 51, 668-677.

(8) Chen, C.; Zhang, Y.; Chen, Z.*; Yang, H.*; Gu, Z.* Cellular transformers for targeted therapy. Adv. Drug Deliv. Rev. 2021, 179, 114032.

(II) Inspired by the nature of metalloenzyme-catalyzed reactions, metal complex (artificial enzymes) or metal nanoparticles (bioorthogonal catalysts) can be synthesized and utilized as abiotic catalysts for deploying artificial chemistry in biological environments.

(1) Chen, Z.; Li, H.; Bian, Y.; Wang, Z.; Chen, G.; Zhang, X.; Miao, Y.; Wen, D.; Wang, J.; Wan, G.; Zeng, Y.; Abdou, P.; Fang, J.; Li, S.; Sun, C.-J.; Gu, Z. Bioorthogonal catalytic patch. Nat. Nanotechnol. 2021, 16, 933-941. (Cover of the August Issue; highlighted by Matter and F1000 Faculty Opinions)

(2) Ouyang, D.; Yang, R.; Yao, Y.*; Jiang, F.; Song, S.; Yang, Y.; Ogunnaike, E. A.; Chen, Z.; Chen, Z.*; Yang, H.* In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy. J. Am. Chem. Soc. 2025, DOI: 10.1021/jacs.5c15945.

(3) Zeng, F.; Pan, Y.; Wu, M.; Lu, Q.; Qin, S.; Gao, Y.; Luan, X.; Chen, R.; He, G.; Wang, Y.; He, B.*; Chen, Z.*; Song, Y*. Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy. ACS Nano 2024, DOI: 10.1021/acsnano.3c09871.

(4) Chen, Z.; Ji, H.; Liu, C.; Bing, W.; Wang, Z.; Qu, X.* A Multinuclear Metal Complex Based DNase-Mimetic Artificial Enzyme: Matrix Cleavage for Combating Bacterial Biofilms. Angew. Chem. Int. Ed. 2016, 55, 10732-10736.

(5) Chen, Z.; Wang, Z.; Ren, J.; Qu, X.* Enzyme Mimicry for Combating Bacteria and Biofilms. Acc. Chem. Res. 2018, 51, 789-799.

(6) Guo, Y.; Jiang, F.; Zhu, X.; He, W.; Song, S.; Shou, X.; Wu, M.; Wu, T.; Huang, T.; Ye, Z.; Wang, X.; Chen, Z.; He, Y.*; Yao, Y.*; Chen, Z.*; Yang, H. An enzyme-gated bioorthogonal catalytic nanoreactor for tumor-specific prodrug activation. Nano Res. 2025, 18, 94907134.

(III) The high spatiotemporal resolution of light makes optical nanomaterials promising for therapeutic/bioimaging studies, and developing optogenetic light delivery devices.

(1) Hong, Z.; Chen, Z.*; Chen, Q.*; Yang, H.* Advancing X-ray Luminescence for Imaging, Biosensing, and Theragnostics. Acc. Chem. Res. 2023, 56, 37-51.

(2) Chen, Z.; Tsytsarev, V.; Finfrock, Y. Z.; Antipova, O. A.; Cai, Z.; Arakawa, H.; Lischka, F. W.; Hooks, B. M.; Wilton, R.; Wang, D.; Liu, Y.; Gaitan, B.; Tao, Y.; Chen, Y.; Erzurumlu, R. S.; Yang, H.; Rozhkova, E. A.* Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles. ACS Nano 2021, 15, 5201-5208.

(3) Tang, X.; Chen, Z.*; Yang, H.* Near-infrared-II-activated photothermal nanotransducers for wireless neuronal stimulation. MedComm – Biomaterials and Applications 2022, 1, e15.

(4) Chen, Z.; Li, Z.; Wang, J.; Ju, E.; Zhou, L.; Ren, J.*; Qu, X.* A Multi-synergistic Platform for Sequential Irradiation-Activated High-Performance Apoptotic Cancer Therapy. Adv. Funct. Mater. 2014, 24, 522-529.

(5) Chen, Z.; Liu, Z.; Li, Z.; Ju, E.; Gao, N.; Zhou, L.; Ren, J.*; Qu, X*. Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis. Biomaterials 2015, 39, 15-22.

(IV) Bioinspired microreactors made of Pickering emulsions, colloidal particle-stabilized droplets, or functional nanomaterial-integrated living cells, for biocatalytic conversion applications and beyond.

(1) Xu, X.; Zhou, M.; Wu, T.; Chen, Z.*; Yang, H.* Pickering emulsion-based biomimetic microreactors. Mater. Chem. Front. 2025, DOI: 10.1039/D5QM00079C.

(2) Xu, X.; Xie, W.; Wu, T.; Chen, C.; Chen, X.; Yang, Y.; Lian, H.; Chen, H.; Cheng, X.; Chen, Z.; Chen, G.; Liu, C.; Chen, L.; He, Y.; Chen, Z.*; Binks, B. P.*; Yang, H.* Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions. Sci. China Chem. 2024, 67, 3039-3049.

(3) Chen, Z.; Rozhkova, E. A.* Intracellular gold nanoclusters boost energy conversion. Nat. Nanotechnol. 2018, 13, 880-881.

(4) Chen, Z.; Zhao, C.; Ju, E.; Ji, H.; Ren, J.;* Binks, B. P.*; Qu, X.* Design of Surface-Active Artificial Enzyme Particles to Stabilize Pickering Emulsions for High-Performance Biphasic Biocatalysis. Adv. Mater. 2016, 28, 1682-1688.

(5) Chen, Z.; Ji, H.; Zhao, C.; Ju, E.; Ren, J.*; Qu, X.* Individual Surface-Engineered Microorganisms as Robust Pickering Interfacial Biocatalysts for Resistance-Minimized Phase-Transfer Bioconversion. Angew. Chem. Int. Ed. 2015, 54, 4904-4908.

(6) Chen, Z.; Zhou, L.; Bing, W.; Zhang, Z.; Li, Z.; Ren, J.*; Qu, X*. Light Controlled Reversible Inversion of Nanophosphor-Stabilized Pickering Emulsions for Biphasic Enantioselective Biocatalysis. J. Am. Chem. Soc. 2014, 136, 7498-7504.

(V) The rich chemical, physical and biological functions of biomolecules, like DNA, protein, and polysaccharides, enabled us to develope advanced theranostic platforms for biomedical engineering applications.

(1) Dai, J.; Liu, Z.; Wang, L.; Huang, G.; Song, S.; Chen, C.; Wu, T.; Xu, X.; Hao, C.; Bian, Y.; Rozhkova, E. A.*; Chen, Z.*; Yang, H.* A Telomerase-Activated Magnetic Resonance Imaging Probe for Consecutively Monitoring Tumor Growth Kinetics and In Situ Screening Inhibitors. J. Am. Chem. Soc. 2023, 145, 1108-1117.

(2) Song, S.; Wang, Q.; Xie, J.; Dai, J.; Ouyang, D.; Huang, G.; Guo, Y.; Chen, C.; Wu, M.; Huang, T.; Ruan, J.; Cheng, X.; Lin, X.; He, Y.*; Rozhkova, E. A.*; Chen, Z.*; Yang, H.* Dual-Responsive Turn-On T1 Imaging-Guided Mild Photothermia for Precise Apoptotic Cancer Therapy. Adv. Healthcare Mater. 2023, 12, 2301437.

(3) Chen, H.; Tang, X.; Huang, Y.; Chen, C.; Yang, Y.; Hao, C.; Xie, W.; Huang, T.; Cheng, X.; Xu, Q.; Huang, S.; Ye, Z.; Lin, X.; Chen, Z.*; Chen, Z.* Remodel the Perifollicular Microenvironment via Minoxidil-loaded Microneedle Patch and Cold Atmospheric Plasma for Treating Androgenetic Alopecia. Nano Res. 2024, DOI: 10.1007/s12274-024-6619-0.

(4) Song, S.; Wang, Q.; Xie, J.; Guo, Y.; He, W.; Yao, Y.; Wang, H.; Huang, B.; Chen, Z.; Lin, X.; He, Y.*; Tian, W.*; Chen, Z.* A DNA machine-based magnetic resonance imaging nanoprobe for in vivo microRNA detection. Talanta 2025, 281, 126867.

(5) Chen, Z.; Liu, C.; Cao, F.; Ren, J.*; Qu, X.* DNA metallization: principles, methods, structures, and applications. Chem. Soc. Rev. 2018, 47, 4017-4072.

博士后（Postdoc）

Chen Chen	Sunhui Chen

博士生（PhD Students)

Mengnan Wu	Sijie Song	Ting Wu	Yuheng Yang
Dilang Ouyang	Ling Xie	Kun Kang	Yang Yang
Jingyin Zheng	Jiazhen Wu	Fuyang Gu

硕士生（Master Students)

Fang Jiang	Rongjin Yang	Min Zhou	Xuan Fan
Yunhao Wang	Tong He	Gongjian Cao	Wanqiong Chen

科研助理（Research Assistants)

Chen Chen (陈琛，PhD, June 2025; Now Joined Postdoc at Fuzhou University and Fujian Provincial People's Hospital)

Xiao Xu (许潇，PhD, June 2025; Now Staff at Linyi Center for Disease Control and Prevention）

Wenqi Xie (谢文琪，Master Degree;June 2025, now Staff at The Experimental School of Jiangsu Xishan Senior High School) 

Wen He (何雯,  Master Degree; June 2025, now Quality Assurance Engineer at Jiangsu Hengrui Pharmaceuticals Co., Ltd.)

Xuecen Shou (寿雪岑,  Master Degree; June 2025, now Project administrator at Pharmaron Beijing Co., Ltd.)

Yuheng Guo (郭宇恒，PhD, March 2025; Now Assistant Professor at Xinjiang Institute of Technology)

Hao Chen (陈好, Master Degree, June 2024; now Medical Product Manager at Peninsula Medical Group Co., Limited)

Tingjing Huang (黄挺菁, Master Degree, June 2024; now PhD student at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences)

Qi Wang (汪琪, Master Degree, June 2024; now Researcher at Ganfeng Lithium Group Co.,Ltd)

Xianzhe Tang (唐贤哲，Master Degree, June 2024; now PhD student at Fudan University)

Chaojie Hao (郝超洁，Bachelor Degree, June 2024; now PhD student at Xiamen University)

Junduan Dai (戴俊端, PhD, June 2023; now Staff at Fuzhou University)

Zheng Liu (刘正, Master Degree, June 2023; now Researcher at Wuxi Biologics)

Baoliu Chen (陈保柳, Master Degree, June 2023; now PhD student at Hainan Univeristy)

Yuchen Guo (郭雨晨，Bachelor Degree, June 2023; now Master student at Xiamen University)

Qianwen Gong (龚倩文，Bachelor Degree, June 2023; now Master student at Fuzhou University)

Jiangting Zeng (曾江婷, Bachelor Degree, June 2022; now Master student at Xiamen University)

Yuhui Zhang (张宇荟, Bachelor Degree, June 2022）

Xiaoning Chen (陈晓宁, Bachelor Degree, June 2021; now Master student at Fuzhou University)

Wei Wang (王伟, Bachelor Degree, June 2021）

Hao Lian (连豪, Master Degree, June 2021; now Researcher in Suzhou City)

课题组常年招收具有化学、药学、生物学、材料学等背景相关专业的硕士、博士、博士后，待遇优厚。

硕士报名系统专业：分析化学、药物、生物与医药、材料与化工；博士专业系统专业：070302分析化学（学术博士）、0703Z1材料化学（学术博士）、085600材料与化工（专业博士）。

有意向者请发送简历至邮箱：chenzw@fzu.edu.cn或zchen88@zju.edu.cn。实验室位置：福州大学国家大学科技园，阳光科技大厦，北510。

Lab location: Fuzhou University, University National Science Park, Yangguang Bldg, Room North 510.

注：以下内容仅代表个人观点以及这些年来所遇到的学生问题，不代表福州大学官方及其他任何教师观点。旁观者请勿对号入座。

1、文章作者如何安排？

答：学生自己的工作，学生自己排第一作者。

2、是否会安排学生做实验室或科研以外的杂活？

答：老师注重学习，只会让学生把精力集中在学习、科研和长技能等方面上，个人事务不麻烦学生。

3、会提供学习和科研上的指导吗？

答：陈老师能做好为人师表的本职工作，实验上遇到问题，会通过组会或平时讨论，分析实验失败的原因，提供相应的建议、寻找解决问题的思路或者直接跟学生一起做实验，解决问题；此外，也会从文献阅读、解析文献、文章写作等方面提供指导；也会及时修改文章，尊重学生的每一个工作，不论发表在哪里，都会认真修改。

4、老师会催着要数据吗？

答：不会push，也不会急于求成。会帮学生制定好规划，以把课题做清楚、做明白为原则，按部就班推进课题进展，不论课题大小。

5、组内氛围如何？

答：组里一定要团结，大家相互尊重，老师也不会挑拨学生恶意竞争。大家来自五湖四海，相聚一起是缘分，希望在组内读书能给每个学生留下一段美好回忆。

6、额外要求有吗？

答：不能在实验室及休息室打游戏、刷视频。

7、是否会延期毕业？

答：老师坚决不会故意延期学生毕业，一切按照福大相关条例进行，只要能达到学校毕业要求，保证让学生及时毕业。

以上内容仅代表个人观点以及这些年来所遇到的报考学生问题，不代表福州大学官方及其他任何教师观点。旁观者请勿对号入座。