2023.02至今 福州大学化学学院，副教授

2020.11-2022.11 波士顿学院(Boston College),美国，博士后，导师: Jianmin Gao教授

2018.11-2020.11 伊利诺伊大学芝加哥分校(University of Illinois at Chicago),美国，博士后，导师: Daesung Lee教授

2016.10-2018.11 中国科学院福建物质结构研究所，博士后，苏伟平教授

2011.9-2016.9 浙江大学化学系，博士，导师：史炳锋教授，吴军教授

2007.9-2011.6 福州大学化学化工学院，本科，导师：陈义平教授，史炳锋教授

主要从事有机化学与多肽化学生物学交叉领域研究，致力于利用有机化学工具解决生物分子（特别是天然多肽）的结构修饰与功能调控难题，为新型多肽药物的开发提供新途径。目前已在Nat. Rev. Chem.、Angew. Chem. Int. Ed.、Chem. Sci.、Org. Lett.等国际刊物上发表SCI论文二十余篇。2篇论文入选ESI高被引论文，2篇热点论文，1篇VIP论文，论文总被引用1300余次。研究成果先后多次被ChemInform,Synfacts,Chin. J. Org. Chem.等作为亮点进行报道。近年来主持国家自然科学基金、福建省自然科学基金、福州大学启动基金等项目。

6. 基于邻近驱动策略的环肽合成研究(2024J08025), 福建省自然科学基金（创青）, 2024-2027, 在研，主持

5. 氯肟在多肽衍生物合成中的应用研究(2024T014)，福州大学贵重仪器设备开放测试基金，2023-2024，在研，主持

4.天然多肽的特异性修饰与拓扑结构调控研究（511264），福州大学“旗山学者”海外项目，2023-2027，在研，主持

3.过渡金属催化的饱和羰基化合物的脱氢/双官能团化串联反应研究（21702205），国家自然科学基金青年项目，2018-2020，已结题，主持

2. β-取代色氨酸合成方法及其在Maremycins和TMC-95A的合成应用研究（21402170），国家自然科学基金青年项目，2015-2017，已结题，参与

1.新型糖肽类抗生素Mannopeptimycins的仿生合成及多样化合成（21272206），国家自然科学基金面上项目，2013-2016，已结题，参与

2024年入选“Wiley China Excellent Author Program”

2024年入选福建省高层次人才（C类）

2023年入选福州大学“旗山学者”（海外项目）

2018年入选中国科学院福建物质结构研究所“精英博士后”

2015年入选浙江大学“优秀研究生”

2011年获得福州大学“优秀本科毕业论文”

23. Fei Hou, Zhi-Gang Liu, Tong-Yao Zhou, Min-Jie Liu, Yuan Tao, Ya-Jiao Zhang*,Fa-Jie Chen*, Fen-Er Chen* "Enantioselective Synthesis of Fused Bicyclic Cyclohexadienes by Rh/Si-SDP-Catalysed [2+2+2] Cycloaddition of 1,6-Diynes with Acrylamides or Enamides"ACS Catalysis,2025,15, 11337–11348.

22. Junwei Han, Qiushuo Zheng, Xin Ding, Yuqin Wen, Nengrong Chen, Wanzhen Lin*, andFa-Jie Chen* "Rapid and Additive-Free Synthesis of β-Sulfido Sulfonyl Fluorides through N-Methyl-2-pyrrolidinone (NMP)-Promoted thia-Michael Addition"J. Org. Chem.,2025, 90, 17, 5856–5861

21. Wanzhen Lin,† Xin Ding,† Jun-Wei Han, Li-Shuang Yu,* andFa-Jie Chen* "Polyfluorinated Reagents for Peptide Stapling"Org. Chem. Front.,2025, 12, 2777 - 2789

20. Zihan Lin, Wanzhen Lin*,Fa-Jie Chen* "Electrochemical Modifications of Native Peptides"Univ. Chem.,2024, 2406089.

19.Chen, Fa-Jie* "Another Side of Side Chains" Nat. Rev. Chem.8, 406-407 (2024)

18. Gu, Wang; Huang, Jingrong, Lu, Yichi; Lin, Wanzhen*; Xu Wei*;Chen, Fa-Jie*"Synthesis of Glycoconjugates through Chlorooxime-Thiol Conjugation"J. Org. Chem.,2024, 89, 9, 6364–6370.

17.Chen, Fa-Jie*;# Lin, Wanzhen;# Chen, Fen-Er* "Non-symmetric Stapling of Native Peptides"Nat. Rev. Chem.,2024, https://doi.org/10.1038/s41570-024-00591-5.

16.Chen, Fa-Jie*;# Pinnette, Nicole;# Gao, Jianmin*. "Strategies for the Construction of Multicyclic Phage Display Libraries"ChemBioChem,2024, e202400072.

15. Ying, Junjie; Huang, Jingrong; Liu, Chenguang;Chen, Fa-Jie*; Xu, Chunfa*; Chen, Fen-Er* "Cu-Catalyzed Arylation of S-Tosyl Peptides with Arylboronic Acids"Org. Chem. Front.,2024,11, 53-59.

14.Chen, Fa-Jie;# Pinnette, Nicole;# Yang, Fan; Gao, Jianmin* "A Cysteine-Directed Proximity-Driven Crosslinking Method for Native Peptide Bicyclization"Angew. Chem. Int. Ed.2023, e202306813.

13.Chen, Fa-Jie; Gao, Jianmin.* "Fast Cysteine Bioconjugation Chemistry"Chem. Eur. J.2022, e202201843. (Invited Review)

12.Chen, Fa-Jie;^#Zheng, Mengmeng,^#Nobile, Vincent, Gao, Jianmin.* "Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes"Chem. Eur. J.2022, e202200058. (Hot paper)

11.Chen, Fa-Jie; Mamidipalli, Phani; Sabbasani, Venkatareddy; Liu, Huaqing; Lee, Daesung* Xia, Yuanzhi*. "Three-component Coupling Reaction for the Synthesis of Fully Substituted Triazoles: Reactivity Control of Cu-Acetylide toward Alkyl Azides and Diazo Compounds"Org. Chem. Front.,2021,8, 6095.

10.Chen, Fa-Jie; Hua, Zhenguo; Chen, Jianhui; Chen, Jiajia; Lee, Daesung* and Xia, Yuanzhi*."One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation"Front. Chem.2020,8, 621545.

9.Chen, Fa-Jie;Lin, Yongjia; Xu, Man; Xia, Yuanzhi*; Wink, Donald J.; Lee, Daesung*. "C–H Insertion by Alkylidene Carbenes to Form 1,2,3-Triazines and Anionic [3 + 2] Dipolar Cycloadditions To Form Tetrazoles: Crucial Roles of Stereoelectronic and Steric Effects"Org. Lett.2020,22, 2, 718-723.

8.Chen, Fa-Jie; Liao, Gang; Li, Xin; Wu, Jun*; Shi, Bing-Feng* "Copper-Mediated C–S/N–S Bond Formation via C–H Activation: Access to Benzoisothiazolones Using Elemental Sulfur"Org. Lett.2014,6, 5644-5647.

7.Chen, Fa-Jie; Zhao, Sheng; Hu, Fang; Chen, Kai; Zhang, Qi; Zhang, Shuo-Qing; Shi, Bing-Feng.* "Pd(II)-Catalyzed Alkoxylation of Unactivated C(sp³)–H and C(sp²)–H Bonds Using a Removable Directing Group: Efficient Synthesis of Alkyl Ethers"Chem. Sci.2013,4, 4187-4192. (Top 25 most-read Chemical Science articles in 2013)(高被引论文)

6. Zheng, Mengmeng;Chen, Fa-Jie, Li, Kaicheng; Reja, Rahi M.; Haeffner, Fredrik; Gao, Jianmin* "Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display"J. Am. Chem. Soc.2022, 144, 15885-15893.

5.Hu, Rong;Chen, Fa-Jie; Zhang, Xiaofeng; Zhang, Min; Su, Weiping.* "Copper-catalyzed Dehydrogenative γ-C(sp³)-H Amination of Saturated Ketones for Synthesis of Polysubstituted Anilines"Nat. Comm.2019,10, 3681.

4.Zhao, Sheng;Chen, Fa-Jie; Liu, Bin; Shi, Bing-Feng.*"Copper-Catalyzed Direct Acyloxylation of C(sp²)-H Bonds with Benzoic Acids"SCIENCE CHINA Chemistry,2015,58, 1302-1309.

3. Zhao, Sheng; Liu, Yue-Jin; Yan, Sheng-Yi;Chen, Fa-Jie; Zhang, Zhuo-Zhuo; Shi, Bing-Feng.* "Copper-/Silver-Mediated Arylation of C(sp²)–H Bonds with 2-Thiophenecarboxylic Acids."Org. Lett.2015,17, 3338-3341.

2. Li, Xin; Liu, Yan-Hua; Gu, Wen-Jia; Li, Bo;Chen, Fa-Jie; Shi, Bing-Feng.* "Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary"Org. Lett.2014,16, 3904-3907.

1.Zhang, Qi; Chen, Kai; Rao, Wei-Hao.; Zhang, Yuejun;Chen, Fa-Jie, Shi, Bing-Feng.* "Stereoselective Synthesis of Chiralα-Amino-β-Lactams via Pd(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp³)–H Bonds"Angew. Chem. Int. Ed.2013,52, 13588-13592.(高被引论文）