王桂美

职 称: 讲师

学 历: 博士研究生

电子邮件: gmwang@fzu.edu.cn

研究方向: 1. 近红外荧光探针的合成及生物成像研究。 2. 诊疗一体化荧光探针的合成及光动力治疗研究。

教育工作经历 (Education and working experiences)

2005-至今福州大学化学学院,讲师

2013-2018,福州大学化学学院,理学博士

2002-2005,福州大学化学学院,理学硕士

1998-2002,山东师范大学化学学院,理学学士

科研简介 (Scientific research)

主要从事近红外功能染料的设计与合成、机理探究,化学传感与生物成像的研究,诊疗一体化荧光探针的合成及光动力治疗性能研究。迄今,在Analytical ChemistrySensors and actuators,B:Chemical,Dyes and pigmengts等学术期刊上发表多篇SCI论文。主持福建省自然科学基金3项。

科研项目 (Scientific research projects)

1.福建省自然科学基金中青年项目,JA13043,基于方酸染料的近红外荧光探针的设计合成及性能研究,2014.07-2016.06,1.5万,已结题,主持。

4. 福建省自然科学基金中青年项目,JAT170104双淬灭效应近红外汞离子探针的设计及成像研究,2017.01-2019.12,0.5万,已结题,主持。

5.国家自然科学基金青年面上项目,2019J01208,特异性检测三磷酸腺苷(ATP)的近红外荧光传感体系的构建与生物成像研究,2019.05-2022.5,10万,已结题,主持。

代表性论文 (Representative papers)

1. Xuyan Wang, Yingying Chen, Chunjiang Liu, Rongjian Sa, Xiaoyi Hu, Juanjuan Chen, Nanyan Fu, andGuimei Wang*,An ONOO/Viscosity-Sensitive and Mitochondria-Targeted Near-Infrared Fluorophore for Real-Time Tracking Mitophagy and Photodynamic Therapy of Cancer.Anal. Chem.2025, 97, 10244−10251.

2.probe for dual-channel tracking ONOOin mitochondria and viscosity in lysosomes in ferroptosis and drug-induced liver injury,Dyes Pigm.2024, 225, 112102.

3.Guimei Wang, Wenjian, Xu, Yunfan, Liu, Nanyan, Fu*, Ultrasensitive detection and high-Contrast bioimaging of Hg2+using monothiosquaraine-based fluorescent probe via hydrogen bond promoted desulfurization A sensitive ratiometric fluorescence Probe.Microchem. J,2022,107481.

4.Guimei Wang, Xiaoxue, Jiang, Nanyan, Fu*, Near-infrared squaraine fluorescent probe for imaging adenosine 5’-triphosphate in live cells.Dyes Pigm.2019,171, 107698.

5.Guimei Wang, Wenjian Xu, Huanghao Yang, Nanyan Fu. Highly sensitive and selective strategy for imaging Hg2+using near-infrared squaraine dye in live cells and zebrafish.Dyes Pigm.2018, 369-376.

6.Guimei Wang,Wenjian Xu,Yanyan Guo,Nanyan Fu. Near-infrared squaraine dye as a selective protein sensor based on self-assembly. Sensors and Actuators B: Chemical, 2017, 245: 932-937.

7.Guimei Wang, Hangqing Chen, Yaqing Chen, Nanyan Fu*,A near-infrared squaraine dye for cascade recognition of copper ion and biologicalphosphate and its application in IMPLICATION logic gate. Sensors and Actuators B: Chemical, 2016, 233,550–558.

8. Guimei Wang, Huijun Zhu, Yaohui Lin, Yaqing Chen, Nanyan Fu, A Ca2+controlled thioether linked bichromophoric squarainefoldamer for “turn on” fluorescent sensing of oxalate.Sensors and Actuators B: Chemical,2015, 206, 624–629.

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