致力于“基于炔烃或吲哚的不对称转化构建手性氮杂环”的研究。结合新催化体系和新型反应试剂的设计与开发，围绕优势骨架的手性氮杂环化合物的构建，发展了氢键导向、共催化和远程手性控制等多种策略，实现炔烃与吲哚的成环反应中化学选择性、区域选择性和立体选择性的精准控制，为结构多样性的手性氮杂环化合物，特别是轴手性化合物的合成提供了高效简洁的新方法。以通讯作者身份发表Sci. Adv.(1篇)、JACS（3篇）、ACIE(1篇)、ACS Central Sci.(1篇)和ACS Catal.(1篇)等论文10余篇。受邀在国内会议和高校做报告10余次。

国家自然科学基金青年项目 （2025-2027）

浙江省自然科学基金/青年探索项目 （2022-2025）

厦门大学固体表面国家重点实验室开放基金 （2021-2022）

2023年，中国产学研合作创新与促进奖产学研合作创新成果奖二等奖

2018年，第十三届福建省自然科学优秀学术论文一等奖

2015年，唐敖庆化学奖学金

1. Cu-Catalyzed Enantioselective and Divergent Synthesis of 5–5-Membered Atropisomers via Direct Atroposelective C–C/C–N Axial Bond Formation. Guan-Zhi Liu, Fu-Cai Rao, Shi-Jie Liu, Wei-Lei Xiang, Peng-Cheng Qian,* Hao Tang,* Yu-Wu Zhong,* Long-Wu Ye, and Long Li.* J. Am. Chem. Soc. 2026, 148, 1465.

2. Divergent and Enantioselective Synthesis of Three Types of Chiral Poly-cyclic N-Heterocycles via Copper-Catalyzed Dearomative Cyclization. Wen-Feng Luo,^# Li-Gao Liu,^# Yan-Xin Zheng,^# Miao Sun, Xin Lu, Bo Zhou, Long-Wu Ye, and Long Li.*ACS Central Sci. 2025, 11, 805.

3. Gold/HNTf₂-Cocatalyzed Asymmetric Annulation of Diazo-Alkynes: Divergent Construction of Atropisomeric Biaryls and Arylquinones. Yi-Bo Wang,^# Wei Liu,^# Ting Li,^# Yazhu Lu, Yi-Tian Yu, Hai-Tao Liu, Meiwen Liu, Pengfei Li, Peng-Cheng Qian,* Hao Tang,* Jia Guan, Long-Wu Ye, and Long Li.* J. Am. Chem. Soc. 2024, 146, 33804.

4. I₂-Catalyzed Cycloisomerization of Ynamides: Chemoselective and Divergent Access to Indole Derivatives. Bo-Han Zhu, Sheng-Bing Ye, Min-Ling Nie, Zhong-Yang Xie, Yi-Bo Wang, Peng-Cheng Qian, * Qing Sun,* Long-Wu Ye, and Long Li.* Angew. Chem., Int. Ed. 2023. 62, e202215616.

5. Ir/Zn-cocatalyzed chemo- and atroposelective [2+2+2] cycloaddition for construction of C−N axially chiral indoles and pyrroles. Jian Yang^#, Zhong-Yang Xie^#, Yu-Jie Ye, Sheng-Bing Ye, Yi-Bo Wang, Wen-Tao Wang, Peng-Cheng Qian,* Ren-Jie Song, Qing Sun,* Long-Wu Ye, and Long Li.* Sci. Adv. 2023. 9, eadk1704.

6. Enantioselective Rh-Catalyzed Azide-Internal-Alkyne Cycloaddition for the Construction of Axially Chiral 1,2,3-Triazoles. Wen-Ting Guo, Bo-Han Zhu, Yi Chen, Jian Yang, Peng-Cheng Qian,* Chao Deng,* Long-Wu Ye, and Long Li.* J. Am. Chem. Soc. 2022, 144, 6981.

7. Stereodivergent Synthesis of Atropisomeric Indole-Fused δ-Lactams Bearing All-Carbon Quaternary Stereocenters via Cu-Catalyzed Desymmetric Arene Amidation. Bo-Han Zhu, Yu-Jie Ye, Guan-Zhi Liu, Si-Chao Wu, Long Li,* Chengzhe Huang,* Qing Sun,* Long-Wu Ye, and Peng-Cheng Qian.* ACS Catal. 2024, 14, 16639.

8. Completing Pyridine-2,6-bis(oxazoline) with Cyclometalated Ligand for Modulated Asymmetric Transition Metal Catalysis.Long Li,† Feng Han,† Xin Nie,† Yubiao Hong, Sergei Ivlev and Eric Meggers,* Angew. Chem., Int. Ed. 2020, 59, 123392. 

9. Zinc-Catalyzed Alkyne Oxidation/C−H Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines. Long Li,† Bo Zhou,† Yong-Heng Wang, Chao Shu, Yi-Fei Pan, Xin Lu,* Long-Wu Ye,* Angew. Chem. Int. Ed. 2015, 54, 8245.

10. Metal-Free Alkene Carbooxygenation Following Tandem Intramolecular Alkoxylation/Claisen Rearrangement: Stereocontrolled Access to Bridged [4.2.1] Lactones. Long Li, Xin-Qi Zhu, Ying-Qi Zhang, Hao-Zhen Bu, Peng Yuan, Jinyu Chen, Jingyi Su, Xianming Deng, Long-Wu Ye,* Chem. Sci. 2019, 10, 3123-3129.

11. Reversal of Regioselectivity in Catalytic Arene-Ynamide Cyclization: Direct Synthesis of Valuable Azepino[4,5-b]indoles and β–Carbolines and DFT Calculations. Long Li, Xiu-Mei Chen, Ze-Shu Wang, Bo Zhou, Xin Liu, Xin Lv,* Long-Wu Ye,* ACS Catal. 2017, 7, 4004.