2015-至今福州大学化学学院，教授、博导。

2011-2015以色列耶路撒冷希伯来大学，化学系，博士后（导师：Itamar Willner教授）。

2005-2011，福州大学化学学院，分析化学，博士研究生（导师：杨黄浩教授）。

2001-2005，福州大学化学学院，化学基地班，理学学士。

主要从事生命分析化学与纳米医学基础及应用研究。在纳米生物传感新技术、功能核酸纳米材料、纳米药物和纳米疫苗等方面，进行较为系统的研究。利用二维材料石墨烯对单链DNA的独特吸附能力和对荧光探针的电子转移猝灭性能，在国际上首次结合氧化石墨烯和生物分子，建立了快速、高灵敏、高选择性检测DNA和蛋白质的新方法。近年来已发表SCI论文140余篇。研究论文总共被引用11064余次，单篇最高被引2228次，30篇被引超过100次，H-index为51，申请发明专利29件，授权15件。主持国家重点研发计划课题，国家自然科学基金面上基金，福建省杰出青年基金等项目。曾获全国优秀博士学位论文提名奖和福建省青年科技奖，入选海外高层次人才引进计划、福建省“闽江学者”特聘教授及福建省百人计划。

国家重点研发计划课题（2018YFA0902602），主持

国家自然科学基金面上项目(22174019，21775025)，主持

海外高层次人才引进计划（青年），主持

福州大学“闽江学者”特聘教授科研启动基金，主持

福建省杰出青年科学基金（2020J06036），主持

国家自然科学基金委联合基金（U1705281），参与

2013年获全国优秀博士学位论文提名奖；

2014年入选福建省“闽江学者”特聘教授；

2015年入选海外高层次人才引进计划（青年类）；

2015年入选福建省第四批引进高层次创业创新人才计划（百人计划）；

2016-2017年度福建省高校领军青年拔尖人才；

2017年获福建省青年科技奖；

2021年获福建省高校优秀共产党员；

2022年获福建省级高层次人才B类。

1.Xiao Fang,^#Yue Wu,^#Yaling Dai,^#Han Xiao, Shiqing Li, Xiaoning Chen, Meng Yuan, Yanbei Guo, Liying Ma, Dingyue Lin, Weilin Liu, Chunhua Lu,* and Huanghao Yang*. In Situ Recovery of Serotonin Synthesis by a Tryptophan Hydroxylase-Like Nanozyme for the Treatment of Depression.J. Am. Chem. Soc.2025, 147(11), 9111-9121

2.Shiqing Li#, Tao Zeng#, Zhixing Wu, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Qi Chen, Chunsen Li, Chunhua Lu,* and Huanghao Yang*. DNA Tetrahedron-Driven Multivalent Proteolysis-Targeting Chimeras: Enhancing Protein Degradation Efficiency and Tumor Targeting.J. Am. Chem. Soc.2025, 147, 2168-2181.

3.Yana Liu,Tao Zeng,Shiyan Bai,XiaoFang,XiupingCao,Shiqing Li,QiChen,Chunhua Lu,* and Huanghao Yang*. Light Triggered "Bacterial Bomb" to Amplify Tumor Pyroptosis.Adv. Funct. Mater.2025,2505784

4.Xiuping Cao#, Liyang Fang#, Yifan Jiang#, Tao Zeng, Shiyan Bai, Shiqing Li, Yana Liu, Wukun Zhong, Chunhua Lu*,andHuanghao Yang*. Nanoscale octopus guiding telomere entanglement: An innovative strategy for inducing apoptosis in cancer cells.Biomaterials2025, 313, 122777

5.Yifan Jiang, Lisha Li, Xiao Fang, Tao Zeng, Lichao Su, Yichang Liu, Ying Wu, Jinyu Li, Peng Lyu, Zhonglei Lu, Chunhua Lu*,andHuanghao Yang*. Self-assembling chemically modified siRNA nanorings for RNAi therapy and neuroprotection in Alzheimer’s disease.Sci. China Chem.2025, 68, 2552-2564

6.Wukun Zhong#, Saijie Wang#, Chunyang Geng#, Yanlin Zheng, Shiyan Bai, Xiuping Cao, Kai Liu, Yang Yang, Chunhua Lu*,andXingyu Jiang*. Multiplexed Random Access Approach to DNA Microspheres for High-Capacity Data Storage.Adv. Funct. Mater.2024, 34(48), 2408852

7.Wukun Zhong, Chunyang Geng, Zhangcheng Fu, Cuiping Mao, Yanlin Zheng, Saijie Wang, Kai Liu, Yang Yang, Chunhua Lu*,andXingyu Jiang*. Flow Cytometry Sorting for Random Access in DNA Data Storage: Encapsulation for Enhanced Stability and Sequence Integrity of DNA.Anal. Chem.2024, 96(40), 16099-16108

8.Yana Liu, Tao Zeng, Chuang Liu, Xiao Fang, Shiqing Li, Xiuping Cao, Chunhua Lu,* and Huanghao Yang*. DNA Origami-Based Letterpress Printing of Gold Nanostructures with Predesigned Morphologies.Nano Lett.2023, 23, 11569−11577.

9.Tao Zeng, Weijie Zang, Han Xiao, Yifan Jiang, Sang Lin, Min Wang, Shiqing Li, Liannishang Li, Chunsen Li, Chunhua Lu*, and Huanghao Yang*. Carrier-Free Nanovaccine: An Innovative Strategy for Ultrahigh Melanoma Neoantigen Loading.ACS Nano2023, 17, 18114-18127.

10.Xiao Fang, Meng Yuan, Fang Zhao, Aoling Yu, Qianying Lin, Shiqing Li, Huichen Li, Xinyang Wang, Yanbin Yu, XinWang, Qitian Lin, Chunhua Lu* and Huanghao Yang*. In situ Continuous Dopa Supply by Responsive Artificial Enzyme for the Treatment of Parkinson’s Disease.Nat. Commun.2023, 14, 2661.

11.Wukun Zhong, Lei Huang, Yuhong Lin, Chao Xing and Chunhua Lu*. Endogenous dual miRNA-triggered dynamic assembly of DNA nanostructures for in-situ dual siRNA delivery.Sci. China Mater.2023, 66, 2938-2946.

12.Tao Zeng, Jiahui Fang, Yifan Jiang, Chao Xing, Chunhua Lu* and Huanghao Yang*. Spherical Nucleic Acid Probe Based on 2′-Fluorinated DNA Functionalization for High-Fidelity Intracellular Sensing.Anal. Chem.2022, 94, 18009-18016.

13.Haihui Wang^#, Han Xiao^#, Xiaohui Zhu, Yongfei Liu, Zhangcheng Fu, Chunsen Li, Chunhua Lu*, and Huanghao Yang*. A Cyanine-Mediated Self-Assembly System for the Construction of a Two-in-One Nanodrug.Angew. Chem. Int. Ed.2021, 60, 21226-21230.

14.Xiao Fang, Shuxian Cai, Min Wang, Zhaowei Chen, Chunhua Lu*,and Huanghao Yang*. Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment.Angew. Chem. Int. Ed.2021, 60, 7046–7050.

15.Shuxian Cai, Ziyi Chen, Yingjie Wang, Min Wang, Junye Wu, Yuhong Tong, Lanlan Chen*, Chunhua Lu*,and Huanghao Yang*. Reducing PD-L1 Expression with a Self-Assembled Nanodrug: an Alternative to PD-L1 Antibody for Enhanced Chemo-Immunotherapy.Theranostics2021, 11, 1970-1981.

16.Yuhong Lin^#, Yuqing Huang^#,Yuling Yang, Lili Jiang, Chao Xing, Jingying Li*, Chunhua Lu*,and Huanghao Yang. Functional Self-Assembled DNA Nanohydrogels for Specific Telomerase Activity Imaging and Telomerase-Activated Antitumor Gene Therapy.Anal. Chem.2020, 92, 22, 15179-15186.

17.Yifan Jiang, Xin Xu, Xiao Fang, Shuxian Cai, Min Wang, Chao Xing, Chunhua Lu*,and Huanghao Yang*. Self-Assembled mRNA-Responsive DNA Nanosphere for Bioimaging and Cancer Therapy in Drug-Resistant Cells.Anal. Chem.2020, 92, 11779-11785.

18.Yuhong Lin, Lili Jiang, Yuqing Huang, Yuling Yang, Yu He, Chunhua Lu*,and Huanghao Yang*. DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network.Chem. Commun.2019, 55, 5387-5390.

19.Lin Zhong,^#Shuxian Cai,^#Yuqing Huang, Litian Yin, Yuling Yang, Chunhua Lu*,and Huanghao Yang*. DNA Octahedron-Based Fluorescence Nanoprobe for Dual Tumor-Related mRNAs Detection and Imaging.Anal. Chem.2018, 90, 12059-12066.

20.Chun-Hua Lu, Alessandro Cecconello, and Itamar Willner*. Recent Advances in the Synthesis and Functions of Reconfigurable Interlocked DNA Nanostructures.J. Am. Chem. Soc.2016, 138, 5172-5185.

21.Chun-Hua Lu,and Itamar Willner*. Stimuli-Responsive DNA-Functionalized Nano-/Microcontainers for Switchable and Controlled Release.Angew. Chem. Int. Ed.2015, 54, 12212-12235.

22.Chun-Hua Lu, Xiu-Juan Qi, Alessandro Cecconello, Stefan-Sven Jester, Michael Famulok,and Itamar Willner*. Switchable Reconfiguration of an Interlocked DNA Olympiadane Nanostructure.Angew. Chem. Int. Ed.2014, 53, 7499-7503.

23.Chun-Hua Lu, Xiu-Juan Qi, Ron Orbach, Huang-Hao Yang, Iris Mironi-Harpaz, Dror Seliktar and Itamar Willner*. Switchable Catalytic Acrylamide Hydrogels Cross-Linked by Hemin/G-Quadruplexes.Nano Lett.2013, 13, 1298-1302.

24.Chun-Hua Lu, Fuan Wang,and Itamar Willner*. Zn²⁺-Ligation DNAzyme-Driven Enzymatic and Nonenzymatic Cascades for the Amplified Detection of DNA.J. Am. Chem. Soc.2012, 134, 10651-10658.

25.Chun-Hua Lu, Juan Li, Mei-Hua Lin, Yi-Wei Wang,andHuang-Hao Yang*, Xi Chen and Guo-Nan Chen. Amplified Aptamer based Assay through Catalytic Recycling of the Analyte.Angew. Chem. Int. Ed.2010, 49, 8454 -8457.

26.Chun-Hua Lu, Huang-Hao Yang*, Chun-Ling Zhu, Xi Chen and Guo-Nan Chen. A Graphene Platform for Sensing Biomolecules.Angew. Chem. Int. Ed.2009, 48, 4785-4787.

Chun-Hua Lu, Wen-Hui Zhou, Bing Han,Huang-Hao Yang*, Xi Chen and Xiao-Ru Wang*. Surface-Imprinted Core-Shell Nanoparticles for Sorbent Assays.Anal. Chem.2007, 79, 5457-5461.