THINK AND DO

	Name:	陈兆委 (Zhaowei Chen)
	Title:	Professor (海外高层次人才、闽江学者特聘教授)
	Degree:	Ph.D. (理学博士)
	Position:	PhD Student Supervisor (博士生导师)
	QQ:	253523348
	Email:	chenzw@fzu.edu.cn | zchen88@zju.edu.cn
	Research:	ChemicalBiology (化学生物学), Artificial cells (人工细胞), Biocatalysis (生物催化), Nanomedicine (纳米医药)
	考研系统报名专业：	分析化学 (学硕、博士)、药学（学硕，药剂/药化/药分）、生物与医药工程 (专硕)

 

 给报考学生留言

2023年博士生、硕士生已经招满，有意向报考陈老师小组的同学，抓紧联系其他老师，也可以联系我们大团队其他老师(请点击查看更多信息https://www.x-mol.com/groups/yang_huanghao/people)。祝一切顺利！

2024年硕士名额有2个，博士名额还有一个空缺，欢迎报考！

Education and Work Experience (教育工作经历)

2021.04 – now:	College of Pharmaceutical Sciences, Zhejiang University, Adjunct Professor (浙江大学，药学学院，兼职教授；顾臻教授(长江学者)团队)
2020.03 – now:	Collge of Chemistry, Fuzhou University, Professor (福州大学，化学学院，教授；杨黄浩教授(长江/杰青)团队)
2019.03 – 2020.03:	University of California-Los Angeles，Postdoc (Supervisor：Zhen Gu, Professor)
2017.06 – 2019.03:	Argonne National Lab，Postdoc (Supervisor：Elena A. Rozhkova, Scientist)
2016.04 – 2017.06:	North Carolina Sate University，Postdoc (Supervisor：Zhen Gu, Professor)
2010.09 – 2016.01:	Changchun Insitute of Applied Chemistry, Ph.D. (Supervisors: 任劲松&曲晓刚, 杰青/杰青)
2006.09 – 2010.07:	Northwestern Polytechnical University (西北工业大学)，B.E.

Courses (教学)

Medical Nanomaterials, 《医用纳米材料》

Principles and Applications of Biocatalysis, 《生物催化反应原理及应用》

Biochemistry,《生物化学》助教

News (组内动态)

2023

June 6 - Baoliu Chen, Junduan Dai, Zheng Liu, Yuchen Guo and Qianwen Gong finished their dissertation defences! A Big Day! Congrats!!

May 24 - Our colloborated work on supramolecular prodrugs with Prof Yang Bai has been published in Nano Research (IF=10.269). Read more...

March 2 - Qi's highlight paper on COVID-2019 detection has been published MedComm - Biomaterials and Applications! Read more...

January 9 - Junduan's work on turn-on T1 magnetic resonance imaging of biomarkers in whole-animal models has been published in JACS. Read more...

2022

December 19 - Our colloborated work with Dr. Zhongzhu Hong, and Profs Qiushui Chen and Huanghao Yang has been published in Accounts of Chemical Research. Read more...

October 26 - Our colloborated work on antibacterial device with Dr Chaoqun Liu and Prof Qiang Wu has been published in Nano Research (IF=10.269). Read more...

September 23 - Xianzhe's Highlight paper on NIR-II Optogenetics has been published MedComm - Biomaterials and Applications! Read more...

September 8 - Our group got a funding support from National Natural Science Foundation of China (￥540,000). Thanks to every group member's hard working.

June 20 - Miss Chaojie Hao, our undergraduate student, has won a ￥10,000 SRTP support! Congrats!!!

June 17 -Welcome Xia Liu, Yuheng Yang, Wenqi, Wen, and Xuecen to join our group!!

2021

October 29 - Miss Chen Chen's paper has been accepted by Advanced Drug Delivery Reviews (IF=15.3). Congrats! Read more...

August 27 - Welcome Dilan, Hao, Qi, Tingjing, and Xianzhe to join the Group!!

August 13 - Dr Zhaowei Chen's work on Bioorthogonal Catalysis has been selected as the Cover of the August Issue, and highlighted by Matter (Cell Press, written by Prof Wenguo Cui), and F1000 Faculty Opinions (written by Prof Xing-Jie Liang).

June 3 - Hao Lian (连豪) finished his Master Degree defense! Congrats!!!

May 10 - Dr Zhaowei Chen's work on Bioorthogonal Catalysis has been published in Nature Nanotechonlogy. Read more...

February 24 - Dr Zhaowei Chen's work on X-ray Optogenetics has been published in ACS Nano. Read more... 

2020

September 8 - Welcome Ting Wu, Mengnan Wu, Baoliu Chen, Sijie Song, Zheng Liu, and Yuheng Guo to join the Group!!

March 23 - Welcome Junduan Dai, Chen Chen, Xiao Xu, and Hao Lian to join the Group!!

February 01 - Dr Zhaowei Chen joined Prof Hanghao Yang's team in the College of Chemistry at Fuzhou Univeristy!!

January 25 - Dr Zhaowei Chen left UCLA and started his new career. 

 Group Members (组内成员)

PhD Students
Chen Chen	Xiao Xu	Yuheng Guo	Xia Liu
Mengnan Wu	Sijie Song	Ting Wu	Yuheng Yang
	Will join soon
Dilan Ouyang	Ling Xie
Master Students
Hao Chen	Qi Wang	Tingjing Huang	Xianzhe Tang
Wen He	Wenqi Xie	Xuecen Shou
Will join soon Nuoxuan Xiong	Will join soon Rongjin Yang	Will join soon Fang Jiang
Undergraduate Students
Chaojie Hao
High School Students
André Yeh  (Fuzhou No3. High School)

 Reserach Overview (科研简介) 

No expertise and a lot of curiosity!

Our group research interests focus on design and synthesis of bioinspired and biomimetic materials for nanomedicince, biomedical engineering, biocatalysis or bioorthogonal catalysis, and X-ray optogenetics applications. We have pulished around 80 high-impact papers, with citations near 6800 and an H-index of 44. 

目前主要从事生命分析化学及化学生物学相关的基础研究与应用，包括仿生人工细胞、生物正交催化/生物催化、纳米医药(针对糖尿病、神经退行性疾病、癌症等疾病)、X射线光遗传学等。近年来已在相关领域发表SCI论文80余篇，其中第一作者/通讯作者论文30余篇，包括：Nat. Nanotechnol. (2篇), Nat. Chem. Biol., Sci. China Life Sci., J. Am. Chem. Soc. (3篇), Angew. Chem. Int. Ed. (3篇), Adv. Mater., Adv. Funct. Mater., Chem. Soc. Rev., Acc. Chem. Res. (5篇), Biomaterials (2篇), Biosens. Bioelectron., Chem. Commun., Chem. Eur. J.。总引用次数6800余次，H-因子44。工作多次被Nature Nanotechnology, Nature Methods, JAMA等亮点报道。

 Research and Publications (研究方向及代表性论文）

  Google Scholar: https://scholar.google.com/citations?user=3SyRXJAAAAAJ&hl=en

(I) Artificial synthetic cells and protocells built upon chemistry, synthetic biology and micro-/nanomaterials for theranostic, biosensing, bioenergy conversion and life-of-origin researches.

1. Z. Chen, J. Wang, W. Sun, E. Archibong, A. R. Kahkoska, X. Zhang, Y. Lu, F. S. Ligler, J. B. Buse and Z. Gu (2018). "Synthetic beta cells for fusion-mediated dynamic insulin secretion." Nature Chemical Biology 14: 86. (Highlighted by NIH blog and JAMA.)

2. Z. Chen, G. De Queiros Silveira, X. Ma, Y. Xie, Y. A. Wu, E. Barry, T. Tajh, H. C. Fry, P. D. Laible, E. A. Rozhkova (2019) “Light-Gated Synthetic Protocells for Plasmon-Enhanced Chemiosmotic Gradient Generation and ATP Synthesis.” Angewandte Chemie International Edition, 58, 4896. (Highlighted by Nature Nanotechnology)

3. Z. Chen, H. Zhang, P. Guo, J. Zhang, G. Tira, Y. J. Kim, Y. A. Wu, Y. Liu, J. Wen, T. Rajh, J. Niklas, O. G. Poluektov, P. D. Laible and E. A. Rozhkova (2019). “Semi-artificial Photosynthetic CO2 Reduction through Purple Membrane Re-engineering with Semiconductor.” Journal of the American Chemical Society 141, 11811.

4. Z. Chen*, D. Wen, & Z. Gu * (2020). “Cargo-encapsulated cells for drug delivery.” Science China Life Sciences 63, 599.

5. X. Han, H. Li, D. Zhou, Z. Chen* and Z. Gu* (2020). “Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics.” Accounts of Chemical Research 53, 2521.

6. Z. Chen, Z. Wang, Z. Gu (2019) “Bioinspired and Biomimetic Nanomedicines” Accounts of Chemical Research, 52, 1255.

7. Z. Chen, Q. Hu, and Z. Gu (2018). “Leveraging Engineering of Cells for Drug Delivery.” Accounts of Chemical Research 51, 668.

8. C. Chen, Y. Zhang, Z. Chen*, H. Yang* and Z. Gu*(2021). Cellular transformers for targeted therapy. Advanced Drug Delivery Reviews 179, 114032.

(II) Inspired by the nature of metalloenzyme-catalyzed reactions, metal complex (artificial enzymes) or metal nanoparticles (bioorthogonal catalysts) can be synthesized and utilized as abiotic catalysts for deploying artificial chemistry in biological environments.

1. Z. Chen, H. Li, Y. Bian, Z. Wang, G. Chen, X. Zhang, Y. Miao, D. Wen, J., G. Wan, Y. Zeng, P. Abdou, J. Fang, S. Li, C. and Z. Gu* (2021).“Bioorthogonal Catalytic Patch.” Nautre Nanotechnology, 16, 933-941. (Cover of the August Issue; highlighted by Matter and F1000 Faculty Opinions)

2. Z. Chen, H. Ji, C. Liu, W. Bing, Z. Wang and X. Qu (2016). "A Multinuclear Metal Complex Based DNase-Mimetic Artificial Enzyme: Matrix Cleavage for Combating Bacterial Biofilms." Angewandte Chemie International Edition 55(36): 10732.

3. Z. Chen, Z. Wang, J. Ren and X. Qu (2018). “Enzyme Mimicry for Combating Bacteria and Biofilms.” Accounts of Chemical Research 51, 789.

(III) The high spatiotemporal resolution of light makes optical nanomaterials promising for therapeutic/bioimaging studies, and developing optogenetic light delivery devices.

1. Z. Hong, Z. Chen,* Q. Chen,* and H. Yang* (2023). "Advancing X-ray Luminescence for Imaging, Biosensing, and Theragnostics". Accounts of Chemical Research 56(1): 37.

2. X. Tang, Z. Chen,* and H. Yang* (2022). "Near-infrared-II-activated photothermal nanotransducers for wireless neuronal stimulation." MedComm – Biomaterials and Applications 1(2): e15.

3. Z. Chen, V. Tsytsarev, Y. Zou Finfrock, O. A. Antipova, Z. Cai, H. Arakawa, F. W. Lischka, B. M. Hooks, R. Wilton, D. Wang, Y. Liu, B. Gaitan, Y. Tao, Y. Chen, R. S. Erzurumlu, H. Yang, and E. A. Rozhkova (2021). "Wireless optogenetic modulation of cortical neurons enabled by radioluminescent nanoparticles." ACS Nano15(3), 5201.

4. Z. Chen, Z. Li, J. Wang, E. Ju, L. Zhou, J. Ren and X. Qu (2014). "A Multi-synergistic Platform for Sequential Irradiation-Activated High-Performance Apoptotic Cancer Therapy." Advanced Functional Materials 24(4): 522.

5. Z. Chen, Z. Liu, Z. Li, E. Ju, N. Gao, L. Zhou, J. Ren and X. Qu (2015). "Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis." Biomaterials 39: 15.

(IV) Bioinspired microreactors made of Pickering emulsions, colloidal particle-stabilized droplets, or functional nanomaterial-integrated living cells, for biocatalytic conversion applications and beyond.

1. Z. Chen, E. A. Rozhkova (2018) “Intracellular gold nanoclusters boost energy conversion.” Nature Nanotechnology, 13, 880.

2. Z. Chen, C. Zhao, E. Ju, H. Ji, J. Ren, B. P. Binks, X. Qu (2016). “Design of Surface-active Artificial Enzyme Particles to Stabilize Pickering Emulsions for High-Performance Biphasic Biocatalysis.” Advanced Materials 28(8): 1682.

3. Z. Chen, H. Ji, C. Zhao, E. Ju, J. Ren and X. Qu (2015). "Individual Surface-Engineered Microorganisms as Robust Pickering Interfacial Biocatalysts for Resistance-Minimized Phase-Transfer Bioconversion." Angewandte Chemie International Edition 54(16): 4904.

4. Z. Chen, L. Zhou, W. Bing, Z. Zhang, Z. Li, J. Ren and X. Qu (2014). "Light Controlled Reversible Inversion of Nanophosphor-Stabilized Pickering Emulsions for Biphasic Enantioselective Biocatalysis." Journal of the American Chemical Society 136(20): 7498.

(V) The rich chemical, physical and biological functions of biomolecules, like DNA, protein, and polysaccharides, enabled us to develope advanced theranostic platforms for biomedical engineering applications.

1. J. Dai, Z. Liu, L. Wang, G. Huang, S. Song, C. Chen, T. Wu, X. Xu, C. Hao, Y. Bian, E.A. Rozhkova,* Z. Chen,* H. Yang* (2023). "A Telomerase-Activated Magnetic Resonance Imaging Probe for Consecutively Monitoring Tumor Growth Kinetics and In Situ Screening Inhibitors", Journal of the American Chemical Society, DOI: 10.1021/jacs.2c10749.

2. Z. Chen, C. Liu, F. Cao, J. Ren and X. Qu (2018). “DNA Metallization: Principles, Methods, Structures and Applications.” Chemical Society Reviews 47, 4017.

3. Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren and X. Qu (2013). "Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery." Biomaterials 34(4): 1364.

4. Z. Chen, L. Zhou, A. Zhao, Z. Zhang, Z. Wang, Y. Lin, J. Ren and X. Qu (2014). "Coupling exonuclease III with DNA metallization for amplified detection of biothiols at picomolar concentration." Biosensors & Bioelectronics 58: 214.

5. Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren and X. Qu (2013). "Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery." Chemistry-a European Journal 19(5): 1778.

6. Z. Chen, Y. Lin, C. Zhao, J. Ren and X. Qu (2012). "Silver metallization engineered conformational switch of G-quadruplex for fluorescence turn-on detection of biothiols." Chemical Communications 48(93): 11428.

 Major Position in Influential Institutions (社会兼职)

1. Independent Reviewer for JACS, Angew. Chem., Advanced Mateirals, Science Advances, Nature Communications, Advanced Functional Mateirals, ACS Nano, Nano Letters, ACS Applied Materials and Interface, Nanoscale, NanoResearch, etc.

2. Guest Editor for Molecules (MDPI), Chemistry (MDPI), etc.

3. Young Editoral Board members of Exploration, Journal of Analysis and Testing.

4. Associate Editor of Chemical Biology, Frontiers in Chemistry.

 Fundings (科研项目)

1. 福州大学“闽江学者”特聘教授科研启动基金 (2020-2023)。

2. 国家海外高层次人才引进启动基金（2021-2025）。

3. 福建省海外高层次人才引进启动基金（2021-2025）。

4. 国家重点研发计划纳米科技重点专项“靶向肿瘤转移节点分子的多模块可编程纳米药物”项目，承担其中课题二的子课题 (2021-2026)。

5. 国家自然科学基金青年项目 （2022-2024）。

6. 国家自然科学基金面上项目（2023-2026）。

 Awards (获得奖项)

1. 国家海外高层才人才青年项目获得者

2. 闽江学者特聘教授

3. 福建省海外高层次人才

4. 中科院优秀博士学位论文

5. 中科院朱李月华优秀博士生奖

6. 博士研究生国家奖学金

 Open Positions (职位信息)

课题组常年招收具有化学、分子生物学、材料学等背景相关专业的硕士、博士、博士后，待遇优厚。有意向者请发送简历至邮箱：chenzw@fzu.edu.cn或zchen88@zju.edu.cn。实验室位置：福州大学国家大学科技园，阳光科技大厦，北509。

Lab location: Fuzhou University, University National Science Park, Yangguang Bldg, Room North 509.

 Questions (考生疑虑解答)

注：以下内容仅代表陈兆委个人观点以及这些年来所遇到报考学生的提问，不代表福州大学官方及其他任何教师观点。旁观者请勿对号入座。

1、文章作者如何安排？

答：上面陈老师第一作者的文章是其在博士和博士后期间发表工作，并非入职福大之后学生的工作。现在组内学生自己的工作，学生自己排第一作者，陈老师不会要第一作者。

2、是否会安排学生做实验室或科研以外的杂活？

答：陈老师注重学习，希望学生把精力集中在学习、科研和长技能等方面上。如果在实在忙不过来的时候，麻烦学生帮忙做自己个人事务时，会自掏腰包提供一定的酬劳。

3、会提供学习和科研上的指导吗？

答：陈老师能做好为人师表的本职工作：实验上遇到问题，会通过组会或平时讨论，帮助分析实验失败的原因，提供相应的实验建议、或者寻找解决方法的思路、或者跟学生一起做实验，解决问题；此外，也会从文献阅读、解析文献、文章写作等方面提供指导；也会及时修改文章，尊重学生的每一个工作，不论发表在哪里，都会认真修改。

但是，需要特别注意，老师主要负责提建议、指导、完善，不是替学生去做事情，希望每位学生能理清思路。陈老师希望学生培养能够自发热爱学习的习惯，积极查阅文献与动脑的能力，最终能成为一个独立思考和解决问题的研究生。

4、老师会催着要数据吗？

答：陈老师不会push。会帮学生制定好规划，以把课题做清楚、做明白为原则，按部就班推进课题进展，不论课题大小。

5、组内氛围如何？

答：陈老师要求组里一定要团结，大家相互尊重，陈老师也不会挑拨学生恶意竞争。大家来自五湖四海，相聚一起是缘分，希望在陈组读书能给每个学生留下一段美好回忆。

6、额外要求有吗？

答：<1> 不能在实验室打游戏、看小说、刷视频。

7、是否会延期毕业？

答：陈老师坚决不会故意延期学生毕业，一切按照福大相关条例进行，只要达到学校毕业要求，会保证让学生按时毕业；如果学生自己因找工作等原因，需要延期，不反对也不强迫。

更多问题可发简历到chenzw@fzu.edu.cn|zchen88@fzu.edu.cn，然后电联。

以上内容仅代表陈兆委个人观点以及这些年来所遇到报考学生的提问，不代表福州大学官方及其他任何教师观点。旁观者请勿对号入座。

 Alumni (已毕业学生)

Junduan Dai (戴俊端, PhD Degree, June 2023)

Zheng Liu (刘正, Master Degree, June 2023

Baoliu Chen (陈保柳, Master Degree, June 2023)

Yuchen Guo (郭雨晨，Bachelor Degree, June 2023)

Qianwen Gong (龚倩文，Bachelor Degree, June 2023)

Jiangting Zeng (曾江婷, Bachelor Degree, June 2022)

Yuhui Zhang (张宇荟, Bachelor Degree, June 2022）

Xiaoning Chen (陈晓宁, Bachelor Degree, June 2021)

Wei Wang (王伟, Bachelor Degree, June 2021）

Hao Lian (连豪, Master Degree, June 2021)