教育工作经历

2013.3至今 福州大学 化学学院工作；
2009.8-2012.12 香港中文大学 化学系 博士；
2004.9-2007.7 福州大学 化学化工学院 硕士；
2000.9-2004.7 福建师范大学 化学系 学士 

教学简介

本科课程：《有机化学》、《有机实验》

研究生课程：《药学综合实验》、《药学研究方法与实验》 

科研简介

研究兴趣：
酞菁类光敏剂的抗肿瘤活性研究
肿瘤靶向纳米光敏药物的研究

社会兼职

科研项目

 国家自然科学基金、福建省自然科学基金、引进人才项目、科研启动基金、福州大学科技发展基金

代表性论文

1. M.-R. Ke, Z. Chen, J. Shi, Y. Wei, H. Liu, S. Huang, X. Li, B.-Y. Zheng, J.-D. Huang*. A smart and visible way to switch the aromaticity of silicon(IV) phthalocyanines. Chem. Commun. 2023, 59, 9832-9935.

2. P.-H. Zhao, Y.-L. Wu, X.-Y. Li, L.-L. Feng, L. Zhang, B.-Y. Zheng, M.-R. Ke*, J.-D. Huang*. Aggregation-Enhanced Sonodynamic Activity of Phthalocyanine–Artesunate Conjugates. Angew. Chem. Int. Ed. 2022, 61, e202113506.

3. Y. Zhao, K.-Q. Zou, W.-X. Zheng, C.-C. Huang, B.-Y. Zheng, M.-R. Ke*, J.-D. Huang*. Solid-state supramolecular structures and excellent photothermal activities of dimeric zinc(II) phthalocyanines axially bridged with bipyridine derivatives. Dyes Pigments 2022, 199, 110037.

4. B.-D. Zheng, Z.-L. Huang, L.-L. Lv, W.-L. Lan, J.-Q. Hu, X. Li, B.-Y. Zheng, M.-R. Ke*, J.-D. Huang*. A pH-sensitive nanoagent self-assembled from a highly negatively-charged phthalocyanine with excellent biosafety for photothermal therapy. J. Mater. Chem. B 2021, 9, 2845–2853.

5. A.-L. Lin , J.-H. Chen , J.-W. Hong , Y.-Y. Zhao , B.-Y. Zheng , M.-R. Ke*, J.-D. Huang. A phthalocyanine-based self-assembled nanophotosensitizer for efficient in vivo photodynamic anticancer therapy. J.. Inorg. Biochem. 2021, 217, 111371.

6. P.-H.Zhao, S.-T. Ma, J.-Q. Hu, B.-Y. Zheng, M.-R. Ke,* J.-D. Huang* Artesunate-Based Multifunctional Nanoplatform for Photothermal/Photoinduced Thermodynamic Synergistic Anticancer Therapy. ACS Appl. Bio Mater. 2020, 3, 7876-7885.

7. A.-L. Lin , P.-P. Fan , S.-F. Liu , J.-H. Chen , Y.-Y. Zhao , B.-Y. Zheng, M.-R. Ke *, J.-D. Huang. A phthalocyanine-based liposomal nanophotosensitizer with highly efficient tumor-targeting and photodynamic activity. Dyes Pigments 2020. 180, 108455.

8. A.-L. Lin, S.g-Z. Li, C.-H. Xu, X. Li, B.-Y. Zheng, J.-J. Gu, M.-R. Ke*, J.-D. Huang*. A pH-responsive stellate mesoporous silica based nanophotosensitizer for in vivo cancer diagnosis and targeted photodynamic therapy. Biomater. Sci. 2019, 7, 211-219.

9. X.-H. Peng, S.-F. Chen, C.-H. Xu, B.-Y. Zheng, M.-R. Ke*, J.-D. Huang*. Synthesis, Spectroscopic and Fibroblast Activation Protein (FAP)-Responsive Properties of Phthalocyanine-Doxorubicin Conjugates. ChemSelect 2018, 3, 5405-5411.

10. M.-R. Ke, S.-F. Chen, X.-H. Peng, Q.-F. Zheng, B.-Y. Zheng, C.-K. Yeh, J.-D. Huang*. A tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy. Eur. J. Med. Chem. 2017, 127, 200-209.

11. Q. Sun, B.-Y. Zheng, Y.-H. Zhang, J.-J. Zhuang, M.-R. Ke*, Jian-Dong Huang*. Highly photocytotoxic silicon(IV) phthalocyanines axially modified with L-tyrosine derivatives: Effects of mode of axial substituent connection and of formulation on photodynamic activity. Dyes Pigments 2017, 141, 521-529.

12. B.-Y. Zheng, M.-R. Ke, W.-L. Lan, L. Hou, J. Guo, D.-H. Wan, L.-Z. Cheong, J.-D. Huang*. Mono- and tetra-substituted zinc(II) phthalocyanines containing morpholinyl moieties: Synthesis, antifungal photodynamic activities, and structure-activity relationships. Eur. J. Med. Chem. 2016, 114, 380-389. (Coauthor)

13. B.-Y. Zheng, X.-M. Shen, D.-M. Zhao, Y.-B. Cai, M.-R. Ke, J.-D. Huang*. Silicon(IV) phthalocyanines substituted axially with different nucleoside moieties. Effects of nucleoside type on the photosensitizing efficiencies and in vitro photodynamic activities. J. Photochem. Photobiol. B 2016, 159, 196-204.

14. W.-L. Lan, F.-R. Liu, M.-R. Ke, P.-C. Lo, W.-P. Fong, D. K. P. Ng*, J.-D. Huang*. The effects of formulation and serum albumin on the in vitro photodynamic activity of zinc(II) phthalocyanines substituted with sulfonated quinolineoxy groups. Dyes Pigments 2016, 128, 215-225.

15.  X. Li, M.-R. Ke, W. Huang, C.-H. Ye, J.-D. Huang*. A pH-Responsive Layered Double Hydroxide (LDH)–Phthalocyanine Nanohybrid for Efficient Photodynamic Therapy. Chem. Eur. J. 2015, 21, 3310-3317. (Coauthor)

16. X. Li, J. Guo, J.-J. Zhuang, B.-Y. Zheng, M.-R. Ke, J.-D. Huang*. Highly positive-charged zinc(II) phthalocyanine as non-aggregated and efficient antifungal photosensitizer. Bioorg. Med. Chem. Lett. 2015, 25, 2386-2389.

17. B.-Y. Zheng, X.-J. Jiang, T. Lin, M.-R. Ke, J.-D. Huang*. Novel silicon(IV) phthalocyanines containing piperidinyl moieties:Synthesis and in vitro antifungal photodynamic activities. Dyes Pigments 2015,112, 311-316.

18. H.-N. Xu, H.-J. Chen, B.-Y. Zheng, Y.-Q. Zheng, M.-R. Ke, J.-D. Huang*. Preparation and sonodynamic activities of water-soluble tetra-a-(3-carboxyphenoxyl) zinc(II) phthalocyanine and its bovine serum albumin conjugate. Ultrason. Sonochem.  2015, 22, 125-131.

19. M.-R. Ke, D. K. P. Ng*, P.-C. Lo*. Synthesis and In Vitro Photodynamic Activities of an Integrin-Targeting cRGD-Conjugated Zinc(II) Phthalocyanine. Chem. Asian J. 2014, 9, 554-561.

20. M.-R. Ke, J. M. Eastel, K. L. K. Ngai, Y.-Y. Cheung, P. K. S. Chan, M. Hui, D. K. P. Ng*, P.-C. Lo*. Oligolysine-Conjugated Zinc(II) Phthalocyanines as Efficient Photosensitizers for Antimicrobial Photodynamic Therapy. Chem. Asian J. 2014, 9, 1868-1875.

21. M.-R. Ke, J. M. Eastel, K. L. K. Ngai, Y.-Y. Cheung, P. K. S. Chan, M. Hui, D. K. P. Ng*, P.-C. Lo*. Photodynamic Inactivation of Bacteria and Viruses Using Two Monosubstituted Zinc(II) Phthalocyanines, Eur. J. Med. Chem. 2014, 84, 278-283.

22. Y.-W. Zheng, S.-F. Chen, B.-Y. Zheng, M.-R. Ke, J.-D. Huang*. A Silicon(IV) Phthalocyanine­Folate Conjugate as an Efficient Photosensitizer. Chem. Lett. 2014, 43, 1701-1703.

23. M.-R. Ke, S.-L. Yeung, D. K. P. Ng*, W.-P. Fong, P.-C. Lo*. Preparation and in Vitro Photodynamic Activities of Folate-Conjugated Distyryl Boron Dipyrromethene Based Photosensitizers, J. Med. Chem.  2013, 56, 8475-8483.

24. X.-W. Chen, M.-R. Ke, X. Li, W.-L. Lan, M.-F. Zhang, J.-D. Huang*. Synthesis, Supramolecular Behavior, and In Vitro Photodynamic Activities of Novel Zinc(II) Phthalocyanines “Side-strapped” with Crown Ether Bridges, Chem. Asian J. 2013, 812, 3063-3070. (Coauthor)

25. B.-Y. Zheng, H.-P. Zhang, M.-R. Ke, J.-D. Huang*.Synthesis and antifungal photodynamic activities of a series of novel zinc(II) phthalocyanines substituted with piperazinyl moieties. Dyes Pigments 2013, 99,185-191.

26. M.-R. Ke, S.-L. Yeung, W.-P. Fong, D. K. P. Ng*, P.-C.i Lo*. A Phthalocyanine-Peptide Conjugate with High In Vitro Photodynamic Activity and Enhanced In Vivo Tumor-Retention Property, Chem. Eur. J. 2012, 18, 4225-4233.

27. M.-R. Ke, D. K. P. Ng*, P.-C. Lo*, A pH-responsive Fluorescent Probe and Photosensitiser Based on a Self-quenched Phthalocyanine Dimer, Chem. Commun. 2012, 48, 9065-9067.

获奖情况

曾亦容奖教金、杨洪耀奖教金等

其他