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姓 名: | 陈涓涓 |
性 别: | 女 |
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职 称: | 副教授 | |
学 历: | 博士 | |
职 务: | ||
电 话: | 059188267963 | |
专 业: | ||
电子邮件: | cjj_pp@126.com | |
研究方向: | 肿瘤治疗和分子诊断 |
教育工作经历
教学简介
无机化学B
实验室安全与环保
科研简介
致力于开展化学、生物与医学交叉领域的研究工作,目前主要集中于肿瘤的光动力治疗以及与疾病相关的分子事件检测。
1. 光动力治疗: 着眼于解决光动力治疗的前沿问题,发展高效精准光敏剂用于肿瘤及相关疾病的治疗。
2. 疾病相关分子事件的检测检测:着眼于当前重大疾病如肿瘤和糖尿病等,发展能够对这些疾病进行及早响应的探针,实现疾病的早期且灵敏的诊断。
科研项目
代表性论文
1. Novel molecular photosensitizer with simultaneously GSH depletion, aggregation inhibition and accelerated elimination for improved and safe photodynamic therapy. European Journal of Medicinal Chemistry 2023, 245, 114938.
2. A novel hierarchical targeting and controllable smart nanoparticles for enhanced in situ nuclear photodynamic therapy, Nano Research, 2022, 15, 4212-422
3. EGFR-targeted photosensitizer for enhanced photodynamic therapy and imaging therapeutic effect by monitoring GSH decline, Sensors and Actuators: B. Chemical, 2022, 355, 131275.
4. A hydrogen sulfide-responsive prodrug for monitoring real-time release and improving therapeutic effects of anticancer drug SN-38. Sensors and Actuators B: Chemical 2022, 373, 132750.
5. A phthalocyanine-based photosensitizer for effectively combating triple negative breast cancer with enhanced photodynamic anticancer activity and immune response. European Journal of Medicinal Chemistry 2022, 241, 114644.
6. A novel zinc phthalocyanine-indometacin photosensitizer with “Three-in-one” cyclooxygenase-2-driven dual targeting and aggregation inhibition for high-effcient anticancer therapy, Dyes and Pigments, 2022, 198, 109997.
7. An aromatase inhibitor in combination with Zinc(II) phthalocyanine for targeted therapy of post-menopausal breast cancer, Dyes and Pigments, 2022, 202, 110281.
8. A glutathione and hydrogen sulfide responsive photosensitizer for enhanced photodynamic therapy. Dyes and Pigments 2022, 205, 110529.
9. A monoamine oxidase-A inhibitor phthalocyanine conjugate for targeted photodynamic therapy and inhibition of prostate cancer metastasis in vitro. Dyes and Pigments 2022, 207, 110717.
10. A novel Pim-1 kinase-targeted photosensitizer to combat triple-negative breast cancer with enhanced photodynamic efficacy and reduced metastasis. Dyes and Pigments 2022, 207, 110778.
11. A MCL-1-targeted photosensitizer to combat triple-negative breast cancer with enhanced photodynamic efficacy, sensitization to ROS-induced damage, and immune response. Journal of Inorganic Biochemistry 2022, 237, 111997.
12. Targeted Drug Delivery System Based on Copper Sulfide for Synergistic Near-Infrared Photothermal Therapy/Photodynamic Therapy/Chemotherapy of Triple Negative Breast Cancer. Langmuir 2022, 38, 15766-15775.
13. Fluorescence-Reporting-Guided Tumor Acidic Environment-Activated Triple Photodynamic, Chemodynamic, and Chemotherapeutic Reactions for EfficientHepatocellular Carcinoma Cell Ablation, Langmuir, 2022, 38, 5381-5391.