教育工作经历

2000.9-2004.7，本科：生物工程专业
2005.9-2007.7，硕士：生物化学与分子生物学专业
2007.9-2010.7，博士：生物化工专业
2010-至今，福州大学化学学院

 

教学简介

本科生：制药分离工程、制药工艺学、生物化学实验、制药工程实训
研究生：制药工艺与工程、高等生物化工教程、生物化工研究方法和实验

 

科研简介

        主要从事海洋药源生物活性物质产业化应用关键技术研究、福建省特色资源有效活性成分的分离纯化技术及产业化技术研究、微生物药物代谢调控及工业规模放大效应和优化控制技术研究、以及抗代谢综合症、抗肿瘤和抗阿尔兹海默症药物的筛选和机理研究工作。主持并参与了十多项国家和省部级科研项目，已在J AGR FOOD CHEM，FOOD CHEM，CARBOHYD POLYM，INT J BIOL MACROMOL等SCI杂志发表论文60余篇，获授权发明专利16项。

 

社会兼职

 

 

科研项目

系列生物敷料技术开发，企业横向，250万，2022-2025年，主持。

莲安神助眠活性组分综合提取技术与产业化，企业横向，35万，2022-2024年，主持。

基于红曲Azaphilone化合物作为幽门螺杆菌与胃癌细胞双重抑制剂的合成与生物学评价（2021J01557），福建省科技厅自然科学基金面上项目，7万，2021-2024年，主持。

海洋硫酸软骨素项目，企业横向，150万，2020-2023年，主持。

红曲霉Azaphilone 化合物化疗光疗双重抗癌机制的研究（2017J01854），福建省科技厅自然科学基金面上项目，9万，2018-2020年，主持。

鱼鳞胶原蛋白生产技术，企业横向，46万，2015-2018年，主持。

胶原蛋白-甲壳胺纳米银烧创伤抗菌敷料的研制及对烧伤深2度创面修复的临床前研究，福建省科技厅社会发展引导性（重点）项目（2014Y0056），5万，2014-2018年，主持。

红曲Azaphilone化合物抗阿尔兹海默症活性研究（2012J05155）， 福建省自然基金项目，3万，2013 -2015年，主持。

甾醇、甾体皂甙活性物质研发与应用研究，国家海洋局公益项目（201205022-7），88万元，2012-2015年，主持。

红曲Azaphilone代谢产物及其衍生物抗AD药效构效关系研究（0041-600367），福大育苗项目，2012 -2014年，主持。

红曲霉Azaphilone类代谢产物及其衍生物抗阿尔兹海默症的研究（0460-022372），福州大学科研启动项目，2011 -2013年，主持。

红曲Azaphilone类化合物的分离纯化及抗癌药效学研究，福建省医疗器械与医药技术重点实验室开放基金（NO.09002），2008 -2012年，主持。

针对KLF5分子靶点的抗三阴性乳腺癌药物发现、结构优化及生物活性评价（81402781），国家自然科学基金，23万元，2015-2018年，排名第二。

螺旋藻的高值化综合开发，企业横向，218万元， 2014-2017年，排名第二。

海洋生物营养成分和活性物提取关键技术研究与开发（2013NZ0003-1），福建省科技厅区域重大专项，450万元，2014-2016年，排名第二。

肺炎链球菌表面蛋白PspA的免疫选秀（2013J01130），国家自然科学基金，23万，2013-2015年，排名第三。

药源生物活性物质产业化应用关键技术研究和示范（201205022），国家海洋局公益项目，2393万元，2012-2015年，排名第三。

具有光动力治疗和化学治疗协同抗肿瘤效应的酶激活式靶向前体药物的合成与构效关系（21172037），国家自然科学基金，60万元，2011-2013年，排名第三。

新型高效海水鱼类弧菌亚单位疫苗的研制（2009N4002），福建省科技厅重点项目，10万元，2010-2012年，排名第二。

 

代表性论文

Haijie Zhang(#), Yinbo Wu, Mengjie Qiu, Yunquan Zheng(*), Li Chen, Xianai Shi, Jianmin Yang, Qiong Lin, Jianqing Lin(*). Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia. Food Bioscience, 2024, 62, 105345.

Mengjie Qiu(#); Yating He; Haijie Zhang; Yunquan Zheng(*); Xianai Shi; Jianmin Yang.  Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair. International Journal of Molecular Sciences, 2024, 25, 9340.

Wenqiang Liao(#), Siqi Xiao(#), Jianmin Yang, Xianai Shi, Yunquan Zheng(*). Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy. Carbohydrate Polymers, 2024, 323, 121416.

Li Zhao(#), Wenqiang Liao(#), Guibin Lin, Jianmin Yang, Xianai Shi, Yunquan Zheng(*). Rubropunctatin-silver composite nanoliposomes for eradicating Helicobacter pyloriin vitro and in vivo. International Journal of Pharmaceutics, 2024, 649, 123655.

Yongjian Cao(#), Haijie Zhang(#), Mengjie Qiu, Yunquan Zheng(*), Xianai Shi, Jianmin Yang(*). Biomimetic injectable and bilayered hydrogel scaffold based on collagen and chondroitin sulfate for the repair of osteochondral defects. International Journal of Biological Macromolecules, 2024, 257, 128593.

Shilong Ning(#), Congchun Wang, Li Zhao, Jianmin Yang, Xianai Shi, Yunquan Zheng(*). Lecithin/chitosan nanoparticle drug carrier improves anti-tumor efficacy of Monascus pigment rubropunctatin. International Journal of Biological Macromolecules, 2023, 242, 125058.

Siqi Xiao(#), Zehua Lu, Jianmin Yang, Xianai Shi, Yunquan Zheng(*). Phycocyanobilin from Arthrospira platensis: A potential photodynamic anticancer agent. Dyes and Pigments, 2023, 219, 111516.

Guibin Lin(#), Chenhui Zhao (#), Wenqiang Liao, Jianmin Yang, Yunquan Zheng(*). Eco‐Friendly Green Synthesis of Rubropunctatin Functionalized Silver Nanoparticles and Evaluation of Antibacterial Activity. Nanomaterials 2022, 12, 4052-4063.

Shiqi Li(#), Xiaoying Zhong(#), Yanan Xu, Yunquan Zheng(*), Xianai Shi, Feng Li, Shaobin Guo, Jianmin Yang(*). Smartphone-based reading system integrated with phycocyanin-enhanced latex nanospheres immunoassay for on-site determination of aflatoxin B1 in foodstuffs[J]. Food Chemistry, 2021, 360, 130019-130027.

Jianmin Yang(#), Yufeng Huang, Jiajia Dai, Xianai Shi,Yunquan Zheng(*). A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model[J]. Regenerative Biomaterials, 2021, 8(4)：1-13

Liangbin Li(#), Xiaoying Zhong(#), Yunquan Zheng(*), Shaobin Guo, Xianai Shi(*), Jiandong Huang.Enhancement of biomass production and productivity of Arthrospira platensis GMPA7 using response surface monitoring methodology and turbidostatic cultivation strategy. Journal of Applied Phycology, 2021, 33(2), 755-763.

Xiaolian Feng(#), Xiaofang Zhang, Shiqi Li, Yunquan Zheng(*), Xianai Shi, Feng Li, Shaobin Guo, Jianmin Yang. Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing. International Journal of Biological Macromolecules, 2020, 164: 626-637.

Dongling Xu(#), Jiming Xie, Xiaolian Feng, Xiaofang Zhang, Zhenzhen Ren, Yunquan Zheng(*),  Jianming Yang. Preparation and evaluation of a Rubropunctatinloaded liposome anticancer drug carrier. RSC Advances, 2020, 17: 10352-10360.

Zhenzhen Ren(#), Yanan Xu, Zhenxin Lu, Zhenzhen Wang, Chengqun Chen, Yanghao Guo, Xianai Shi, Feng Li, Jianmin Yang, Yunquan Zheng(*). Construction of Water-soluble and Photostable Rubropunctatin cyclodextrin Drug Carrier. RSC Advances, 2019, 9: 11396-11405.

Yunquan Zheng(#)(*); Liuda Mo; Wenyi Zhang; Yunjian Duan; Jiandong Huang; Chengqun Chen; Yueming Gao; Xianai Shi; Feng Li; Jianmin Yang; Yanghao Guo. Phycocyanin fluorescent probe from Arthrospira platensis: preparation and application in LED-CCD fluorescence density strip qualitative detection system. Journal of Applied Phycology, 2019, 31(2): 1107-1115.

Shengxue Hu(#), Xianqun Cai, Xin Qu, Bangrui Yu, Chenyan Yan, Jianmin Yang(*), Feng Li, Yunquan Zheng, Xianai Shi(*). Preparation of biocompatible wound dressings with long-term antimicrobial activity through covalent bonding of antibiotic agents to natural polymers. International Journal of Biological Macromolecules, 2019, 123: 1320-1330.

Zheng Yunquan(#); Li Liangbin; Shi Xianai(*); Huang Zhijian; Li Feng; Yang Jianmin; Guo Yanghao. Nonionic surfactants and their effects on asymmetric reduction of 2-octanone with Saccharomyces cerevisiae. AMB Express, 2018, 8(1): 111-117.

Zheng Yunquan(#)(*); Pan Qisheng; Mo Liuda; Zhang Wenyi; Duan Yunjian; Chen Chengqun; Chen Haijun; Guo Yanghao; Shi Xianai; Yang Jianmin. Monascus pigment rubropunctatin derivative FZU-H reduces A beta(1-42)-induced neurotoxicity in Neuro-2A cells. RSC Advances, 2018, 8(31): 17389-17398.

Xianqun Cai(#), Shengxue Hu, Bangrui Yu, Yilei Cai, Jianmin Yang(*), Feng Li, Yunquan Zheng, Xianai Shi(*). Transglutaminase-catalyzed preparation of crosslinked carboxymethyl chitosan/carboxymethyl cellulose/collagen composite membrane for postsurgical peritoneal adhesion prevention. Carbohydrate Polymers, 2018, 201: 201-210.

Wan Dong Hua(#); Zheng Bi Yuan; Ke Mei Rong; Duan Ji Ying; Zheng Yun Quan; Yeh Chih Kuang; Huang Jian Dong(*). C-Phycocyanin as a tumour-associated macrophage-targeted photosensitiser and a vehicle of phthalocyanine for enhanced photodynamic therapy. Chemical Communications, 2017, 53(29): 4112-4115.

Chen Yingyu(#); Li Cailong; Zheng Yunquan; Gao Yu; Hu Jianda(*); Chen Haijun(*). Discovery of FZU-03,010 as a self-assembling anticancer amphiphile for acute myeloid leukemia. Bioorganic & Medicinal Chemistry Letters, 2017, 27(4): 1007-1011.

Yunquan Zheng(#)(*); Yun Zhang; Deshan Chen; Haijun Chen; Ling Lin; Chengzhuo Zheng; Yanghao Guo. Monascus Pigment Rubropunctatin: A Potential Dual Agent for Cancer Chemotherapy and Phototherapy. Journal of Agricultural and Food Chemistry, 2016, 64(12): 2541-2548.

Haijun Chen(#); Yu Gao; Ailan Wang; Xiaobin Zhou; Yunquan Zheng; Jia Zhou. Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents. European Journal of Medicinal Chemistry, 2015, 92: 648-65.

Haijun Chen(#); Xiaobin Zhou; Ailan Wang; Yunquan Zheng; Yu Gao; Jia Zhou. Evolutions in fragment-based drug design: the deconstruction–reconstruction approach. Drug Discovery Today, 2015, 20(1): 105-113.

Yu Gao(#), Zhihong Li, Chaoqun Wang, Jiali You, Biyu Jin, Fan Mo, Jianzhong Chen, Yunquan Zheng, Haijun Chen. Self-assembled chitosan/rose bengal derivative nanoparticles for targeted sonodynamic therapy: Preparation and tumor accumulation. RSC Advances, 2015, 5(23): 17915-17923.

Henan Xu(#), Haijun Chen, BiyuanZheng, Yunquan Zheng, Meirong Ke, Jiandong, Huang(*). Preparation and sonodynamic activities of water-soluble tetra-α-(3-carboxyphenoxyl) zinc(II) phthalocyanine and its bovine serum albumin conjugate. Ultrasonics Sonochemistry, 2015, 22: 125-131.

Li, Yongning(#); Wu, Haiyan; Guo, Liangqia; Zheng, Yunquan; Guo, Yanghao(*). Microsphere-based flow cytometric immunoassay for the determination of citrinin in red yeast rice. Food Chemistry, 2012.10.15, 134(4): 2540-2545.

Bai, Kai-Kai(#); Chen, Fen-Ling; Yu, Zhou; Zheng, Yun-Quan; Li, Yong-Ning; Guo, Yang-Hao(*). Synthesis of [3 beta-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its antitumor effects against BGC-823. Bioorganic & Medicinal Chemistry, 2011, 19(13): 4043-4050.

Zheng, Yunquan(#); Xin, Yanwen; Shi, Xianai; Guo, Yanghao(*). Cytotoxicity of Monascus Pigments and Their Derivatives to Human Cancer Cells. Journal of Agricultural and Food Chemistry, 2010, 58(17): 9523-9528.

Zheng, Yunquan(#); Xin, Yanwen; Shi, Xianai; Guo, Yanghao(*). Anti-cancer effect of rubropunctatin against human gastric carcinoma cells BGC-823. Applied Microbiology and Biotechnology, 2010, 88(5): 1169-1177.

Zheng, Yunquan(#); Xin, Yawen; Guo, Yanghao(*). Study on the fingerprint profile of Monascus products with HPLC-FD, PAD and MS. Food Chemistry, 2009, 113(2): 705-711.

Yunquan Zheng(#), Yanghao Guo(*). Study on the pigment metabolites produced by Monascus sp. MFL06. Journal of Biotechnology, 2008, 136(S1): 515.

 

获奖情况

 

 

其他