欧敏锐
日期:2021-11-01 阅读次数: 作者: 来源:




姓    名:     欧敏锐
性    别:

     

职    称: 副教授(硕导)
学    历: 研究生(博士)
职    务:
电    话: 13960789220
专    业: 生物工程、生物化学与分子生物学、物理化学
电子邮件: omr0464@sina.com
研究方向: 天然产物研发及计算机辅助药物设计


教育工作经历

教育经历: 
1995.9-1999.7 福建师范大学生物工程学院 本科 发酵工程专业(现改为生物工程) 
1999.9-2002.7 福建师范大学生物工程学院 硕士 生物化学与分子生物学专业 
2005.9-2012.7 福州大学化学化工学院 博士 物理化学专业 
工作经历: 

2002.8-至今 福州大学化学化工学院 工作

2014.11-2020.11 福州大学化学工程与技术 博士后

2018.12-2019.12 加拿大卡尔顿大学 访学


教学简介

本科教学:《药物化学》、《天然药物化学》、《药理学》、《微生物制药》、《药物生物技术》、《计算机辅助药物设计》等课程及制药工程专业相关实验、实习、实践课程; 
研究生教学:《高等药理学》《生化反应工程》《生物化工工艺学》《海洋药物开发》等课程; 
校选课:《生活药学》《工程伦理》


科研简介

主要从事天然产物研发、计算机辅助药物设计、生物医用高分子材料设计。
参加国家自然科学基金项目一项(排名第二),参加其他项目多项; 
主持福建省自然科学基金项目一项,福州大学科技发展基金及博士科研启动项目各一项,指导SRTP项目15项,已发表论文50余篇;   
 

科研项目

主持或参加科研项目情况: 

1、福州大学人才基金项目,XRC-1608、海西药物与制药装备研究设计启动项目、2016/01-2018/12400.0万元、已结题、参加。

2、福州大学博士科研启动项目,基于5α-还原酶与雄激素受体的双效药物设计和筛选、2014/03-2017/032.5万元、已结题、主持。
3
、国家自然科学基金面上项目,21171039、钒酸盐光催化活性和晶面稳定性调控机理的理论研究、2012/01-2015/1255.0万元、已结题、参加。
4
、教育部博士点基金,20103514110002、肾上腺素能药的不对称转化与分子催化、2011/01-2013/126.0万元、已结题、参加。
5
、福州大学科技发展基金,2010-XY-95α-还原酶抑制剂的分子设计与合成、2010/01-2013/121.5万元、已结题、主持。
6
、国家自然科学基金面上项目,20773024、固体表面反应机理的轨道作用分析方法与应用、2008/01-2010/1226.0万元、已结题、参加。
7
、福建省自然科学基金,2008J0100、苯乙醇胺类手性药物的生物转化及分子催化机制、2008/01-2010/126.0万元、已结题、参加。
8
、福建省自然科学基金,2006J03605α-还原酶的分子模拟及其抑制剂的分子设计、2006/01-2007/121.0万元、已结题、主持。
9
、福建省科技厅,702005I010、新型纳米靶向缓释抗癌药物的制备、表征与分子模拟、2005/01-2007/1213.0万元、已结题、参加。


代表性论文

硕士学位论文:白芥子抑制前列腺增生的药学研究.(入选中国优秀硕士学位论文全文数据库) 
博士学位论文:雄激素依赖型疾病相关靶点的分子模拟与分子对接. 


近期论文:ORCID:https://orcid.org/0000-0001-7263-6647

(1)  Minrui Ou*, Wanying Li, Zhixuan Huang, Xiaoping Xu*, Highly efficient extraction of uranium (VI) from seawater by polyamidoxime/polyethyleneimine sponge. Separation and Purification Technology 2024, 331, 125721.

2Minrui Ou; Wanying Li; Zihui Zhang; Xiaoping Xu ; Adsorption of uranium(VI) with a novel AMPS-modified thermostable β-cyclodextrin biosorbent, Journal of Radioanalytical and Nuclear Chemistry, 2023,332, 23–32.    

3Minrui Ou; Wanying Li; Zihui Zhang; Xiaoping Xu ; β-Cyclodextrin and diatomite immobilized in sodium alginate biosorbent for selective uranium(VI) adsorption in aqueous solution, International Journal of Biological Macromolecules, 2022, 222(12): 2006-2016    

4Ou Minrui; Zhang Zihui; Wen Yukai; Xu Xiaoping; Yang Huanghao ; A Sensitive Material for Specifically Treating Tetracycline in Water Environment, Chinese Journal of Structural Chemistry, 2021, 40(5): 646-652   

5 Zhang Zi-Hui; Zhang Wen; Xu Xiao-Ping; Ou Min-Rui* ; Preparation and Characterization of beta-Cyclodextrin/Poly(acrylic acid)/Permutite Hydrogel Composite for U(VI) Adsorption, Chinese Journal of Structural Chemistry, 2020, 39(10): 1795-1806

6Minrui Ou; Zihui Zhang; Yukai Wen; Huanghao Yang; Junjie Gu; Xiaoping Xu ; Cytotoxic study in the treatment of tetracycline by using magnetic Fe3O4PAMAMantibody complexes, Environmental Chemistry Letters, 2019, 17: 543-549      

7Ou Minrui; Zhang Zihui; Chen Zhihong; Wen Yukai; Yang Huanghao; Xu Xiaoping ; Preparation and Characterization of Magnetic Fe_3O_4-PAMAM-antibody Complex and Its Application in the Removal of Tetracycline from Wastewater, Chinese Journal of Structural Chemistry, 2019, 38(7): 1136-1145


专利:

1欧敏锐(#); 张子惠; 许小平, 一种重金属复合吸附材料及其制备方法与应用, 2019.08.30, ZL 2019 1 0811216.9

2欧敏锐(#); 许小平; 祝令辉; 谷俊杰, 一种从无患子中制备常春藤皂苷元的方法, 2016.6.20, ZL201610450153.5

3)许小平(#);张子惠; 欧敏锐; 温昱恺; 谷俊杰, 一种磁性四氧化三铁-PAMAM-抗体复合体及其制备方法和应用, 2019.10.17, ZL201910988626.0

4)许小平(#);魏聪聪; 欧敏锐; 祝令辉; 谷俊杰, 一种阳离子染料复合吸附材料的制备方法及应用, 2018.3.12, ZL201810200366.1

5)许小平(#); 胥智群; 欧敏锐; 祝令辉; 谷俊杰, 荧光探针的制备方法及基于荧光探针的土霉素检测方法, 2016.6.21, ZL201610451659.8

6)许小平(#); 房贺; 欧敏锐; 祝令辉; 谷俊杰, 一种吸附溴酚蓝的微球及其制备方法与应用, 2016.7.8, CN201610534816.1

7)许小平(#); 伊晓峰; 欧敏锐; 祝令辉; 谷俊杰, 一种聚丙烯酸水凝胶吸附材料的制备方法及应用, 2016.11.29, CN201611072981.6

8)许小平(#);虢学勇; 谷俊杰; 欧敏锐, 一种提高静电纺丝明胶膜水溶性的处理方法及应用, 2018.03.12, CN201810200367.6

9)许小平(#); 吴峤; 谷俊杰; 欧敏锐, 一种以聚丙烯腈微球为载体固定化酪氨酸酶的方法及应用, 2016.11.29, CN201611073633.0

10)陈海军; 周小斌; 王爱兰; 俞雪梅; 胡子旋; 郑小梅; 欧敏锐; 高瑜, 一种靶向STAT3的小分子化合物及其制备方法和应用, 2015.7.22, ZL201410021907.6


以往论文:

(1)Wang, Shuai(#); Fang, He; Yi, Xiaofeng; Xu, Zhiqun; Xie, Xiaodong; Tang, Qiao; Ou, Minrui(*); Xu, Xiaoping(*), Oxidative removal of phenol by HRP-immobilized beads and its environmental toxicology assessment, Ecotoxicology and Environmental Safety, 2016.8, 130: 234~239

(2)Xu, Zhiqun(#); Yi, Xiaofeng; Wu, Qiao; Zhu, Yincan; Ou, Minrui(*); Xu, Xiaoping(*), First report on a BODIPY-based fluorescent probe for sensitive detection of oxytetracycline: application for the rapid determination of oxytetracycline in milk, honey and pork, Rsc Advances, 2016, 6(92): 89288~89297 

(3)Yi, Xiaofeng(#)(*); He, Jiarui; Guo, Yingyuan; Han, Zhenhua; Yang, Meixia; Jin, Jiali; Gu, Junjie; Ou, Minrui; Xu, Xiaoping(*), Encapsulating Fe3O4 into calcium alginate coated chitosan hydrochloride hydrogel beads for removal of Cu (II) and U (VI) from aqueous solutions, Ecotoxicology and Environmental Safety, 2018.1, 147: 699~707   

(4)Xu, Zhiqun(#); Wei, Congcong; Jin, Jiali; Xu, Wenkai; Wu, Qiao; Gu, Junjie; Ou, Minrui; Xu, Xiaoping(*), Development of a Novel Mixed Titanium, Silver Oxide Polyacrylonitrile Nanofiber as a Superior Adsorbent and its Application for MB Removal in Wastewater Treatment, Journal of the Brazilian Chemical Society, 2018.3, 29(3): 560~570    

(5)Yi, Xiaofeng(#)(*); Yang, Meixia; Mo, Liuda; Xu, Wenkai; Wang, Shuai; He, Jiarui; Gu, Junjie; Ou, Minrui; Xu, Xiaoping(*), Modification of chitosan/calcium alginate/Fe3O4 hydrogel microsphere for enhancement of Cu(II) adsorption, Environmental Science and Pollution Research, 2018.2, 25(4): 3922~3932   

(6)Yi, Xiaofeng(#)(*); Xu, Zhiqun; Liu, Yan; Guo, Xueyong; Ou, Minrui; Xu, Xiaoping(*), Highly efficient removal of uranium(VI) from wastewater by polyacrylic acid hydrogels, Rsc Advances, 2017, 7(11): 6278~6287   

(7)Xu, Zhiqun(#); Wu, Qiao; Duan, Yunjian; Yang, Meixia; Ou, Minrui; Xu, Xiaoping(*), Development of a Novel Spectrophotometric Method Based on Diazotization-Coupling Reaction for Determination of Bisphenol A, Journal of the Brazilian Chemical Society, 2017, 28(8): 1475~1482  

(8)Wu, Qiao(#); Xu, Zhiqun; Duan, Yunjian; Zhu, Yincan; Ou, Minrui; Xu, Xiaoping(*), Immobilization of tyrosinase on polyacrylonitrile beads: biodegradation of phenol from aqueous solution and the relevant cytotoxicity assessment, Rsc Advances, 2017, 7(45): 28114~28123 

(9).OU Min-Rui LI Jun-Qian. 2D-QSAR Studies on Phenoxybenzoic Acid Derivatives: A Novel Class of 5a-reductase inhibitors.Chinese J.struct.chem.2008 vol 27.(1): 105-111 

(10).OU Min-Rui LI Jun-Qian. Modeling Steroid 5alpha-reductase and Characterizing its Potential Active Sites.Chinese J. Struct. Chem. 2012 Vol. 31 (11): 1618-1626 
(11).OU Min-Rui LI Jun-Qian. Computational Investigation on the Allosteric Modulation of Androgen Receptor.Chinese J. Struct. Chem. 2012 Vol. 31 (12): 1868-1877 
(12).[An experimental study(I) on the inhibition of prostatic hyperplasia with extract of seeds of Brassica alba].Wu GX, Lin YX, Ou MR, Tan DF. 
Zhongguo Zhong Yao Za Zhi. 2002 Oct;27(10):766-8. Chinese. 
PMID: 12776559 [PubMed - indexed for MEDLINE] 
(13).[An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba].Wu GX, Lin YX, Ou MR, Tan DF. 
Zhongguo Zhong Yao Za Zhi. 2003 Jul;28(7):643-6. Chinese. 
PMID: 15139111 [PubMed - indexed for MEDLINE] 
(14).A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis. 
Liping Xiang · Ting Chi · Qiao Tang · Xiang Yang · Minrui Ou · Xiufen Chen · Xiaobo Yu · Jianzhong Chen · Rodney J Y Ho · Jingwei Shao · Lee Jia 
Oncotarget 03/2015; 
Impact Factor 6.63 
(15).Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis 
Jichuang Wang · Zhou Jiang · Liping Xiang · Yuanfang Li · Minrui Ou · Xiang Yang · Jingwei Shao · Yusheng Lu · Lifeng Lin · Jianzhong Chen · Yun Dai · Lee Jia 
Scientific Reports 05/2014; 4:5006.DOI:10.1038/srep05006 
Impact Factor 5.58 
(16).UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma 
Haiyan Dong · Xiang Yang · Jingjing Xie · Liping Xiang · Yuanfang Li · Minrui Ou · Ting Chi · Zhenhua Liu · Suhong Yu · Yu Gao · Jianzhong Chen · Jingwei Shao · Lee Jia 
Biochemical Pharmacology 12/2014; 93(2).DOI:10.1016/j.bcp.2014.11.014 
Impact Factor 4.65 
(17).Synthesis, Spectral Characterization, and In Vitro Cellular Activities of Metapristone, a Potential Cancer Metastatic Chemopreventive Agent Derived from Mifepristone (RU486) 
Jichuang Wang · Jianzhong Chen · Liyuan Wan · Jingwei Shao · Yusheng Lu · Yewei Zhu · Minrui Ou · Suhong Yu · Haijun Chen · Lee Jia 
The AAPS Journal 01/2014; 16(2). DOI:10.1208/s12248-013-9559-2 
Impact Factor 3.91 
(18).Synthesis and biological evaluation of novel Ursolic Acid derivatives as potential anticancer prodrugs 
Xiang Yang · Yuanfang Li · Wei Jiang · Minrui Ou · Yali Chen · Yu Xu · Qiong Wu · Qing Zheng · Fuqiang Wu · Lue Wang · Wentao Zou · Yitong J Zhang · Jingwei Shao 
Chemical Biology & Drug Design 06/2015;DOI:10.1111/cbdd.12608 
Impact Factor 2.51 


获奖情况

 


其他

 


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