教育工作经历

2001-2005：福州大学化学化工学院 化学基地班 学士

2005-2011：福州大学化学化工学院 分析化学 博士（导师：杨黄浩教授）

2011-2015：以色列耶路撒冷希伯来大学 化学系 博士后（导师：Itamar Willner教授）

2015-至今：福州大学化学学院

教学简介

《无机与分析化学》

《核酸化学》

科研简介

主要从事生命分析化学与纳米医学基础及应用研究。在纳米生物传感新技术，DNA超分子纳米结构，纳米分子影像探针等方面，进行较为系统的研究。利用二维材料石墨烯对单链DNA的独特吸附能力和对荧光探针的电子转移猝灭性能，在国际上首次结合氧化石墨烯和生物分子，建立了快速、高灵敏、高选择性检测DNA和蛋白质的新方法。近年来已发表SCI论文100余篇，论文总共被引用9300余次，单篇最高被引2008次，28篇被引超过100次，H-index为46，申请发明专利20件，授权10件。主持国家重点研发计划课题，国家自然科学基金面上基金，福建省杰出青年基金等项目。曾获全国优秀博士学位论文提名奖和福建省青年科技奖，入选福建省“闽江学者”特聘教授、福建省百人计划及海外高层次人才引进计划。

社会兼职

科研项目

1、国家重点研发计划课题（2018YFA0902602），主持

2、国家自然科学基金面上项目(22174019，21775025)，主持

3、海外高层次人才引进计划（青年），主持

4、国家自然科学基金委联合基金（U1705281），参与

5、福州大学“闽江学者”特聘教授科研启动基金，主持

6、福建省杰出青年科学基金（2020J06036），主持

代表性论文

1. Yana Liu, Tao Zeng, Chuang Liu, Xiao Fang, Shiqing Li, Xiuping Cao, Chunhua Lu,* and Huanghao Yang. DNA Origami-Based Letterpress Printing of Gold Nanostructures with Predesigned Morphologies. Nano Lett. 2023, 23, 11569−11577.

2. Tao Zeng, Weijie Zang, Han Xiao, Yifan Jiang, Sang Lin, Min Wang, Shiqing Li, Liannishang Li, Chunsen Li, Chunhua Lu*, and Huanghao Yang*. Carrier-Free Nanovaccine: An  Innovative Strategy for Ultrahigh Melanoma Neoantigen Loading. ACS Nano 2023, 17, 18114-18127.

3. Xiao Fang, Meng Yuan, Fang Zhao, Aoling Yu, Qianying Lin, Shiqing Li, Huichen Li, Xinyang Wang, Yanbin Yu, XinWang, Qitian Lin, Chunhua Lu* and Huanghao Yang*. In situ Continuous Dopa Supply by Responsive Artificial Enzyme for the Treatment of Parkinson’s Disease. Nat. Commun. 2023, 14, 2661.

4. Wukun Zhong, Lei Huang, Yuhong Lin, Chao Xing and Chunhua Lu*. Endogenous dual miRNA-triggered dynamic assembly of DNA nanostructures for in-situ dual siRNA delivery. Sci. China Mater. 2023, 66, 2938-2946.

5. Ziyi Chen, Xin Wang, Yihang Ding, Chao Xing*, Chunhua Lu* and Xiankun Tu*. A Self-Assembled Copper-Selenocysteine Nanoparticle for Enhanced Chemodynamic Therapy via Oxidative Stress Amplification. ACS Materials Lett. 2023, 5, 1237-1244.

6. Tao Zeng, Jiahui Fang, Yifan Jiang, Chao Xing, Chunhua Lu* and Huanghao Yang. Spherical Nucleic Acid Probe Based on 2′-Fluorinated DNA Functionalization for High-Fidelity Intracellular Sensing. Anal. Chem. 2022, 94, 18009-18016.

7. Yifan Jiang^#, Yichang Liu^#, Min Wang, Zhi Li, Lichao Su, Xin Xu, Chao Xing, Jinyu Li, Lisen Lin, Chunhua Lu,* and Huanghao Yang*. siRNA-Based Carrier-Free System for Synergistic Chemo/Chemodynamic/RNAi Therapy of Drug-Resistant Tumors. ACS Appl. Mater. Interfaces 2022, 14, 361-372.
   

8. Chao Xing^#, Shan Chen^#, Qitian Lin, Yuhong Lin, Min Wang, Jun Wang*, and Chunhua Lu*. An aptamer-tethered DNA origami amplifier for sensitive and accurate imaging of intracellular microRNA. Nanoscale 2022, 14, 1327-1332.

9. Haihui Wang^#, Han Xiao^#, Xiaohui Zhu, Yongfei Liu, Zhangcheng Fu, Chunsen Li, Chunhua Lu*, and Huanghao Yang*. A Cyanine-Mediated Self-Assembly System for the Construction of a Two-in-One Nanodrug. Angew. Chem. Int. Ed. 2021, 60, 21226-21230.

10. Haihui Wang, Yongfei Liu, Xiaohui Zhu, Chengyun Chen, Zhangcheng Fu, Min Wang, Danying Lin, Zhaowei Chen, Chunhua Lu*, and Huanghao Yang*. Multistage Cooperative Nanodrug Combined with PD-L1 for Enhancing Antitumor Chemoimmunotherapy. Adv. Healthc. Mater. 2021, 10(21), 2101199

11. Xiao Fang, Shuxian Cai, Min Wang, Zhaowei Chen, Chunhua Lu* and Huanghao Yang*. Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment. Angew. Chem. Int. Ed. 2021, 60, 7046–7050.

12. Junduan Dai, Chao Xing, Yuhong Lin, Yuqing Huang, Yuling Yang, Zhaowei Chen, Chunhua Lu* and Huanghao Yang*. Localized DNA catalytic hairpin assembly reaction on DNA origami for tumor-associated microRNA detection and imaging in live cells. Sensor Actuat B-Chem. 2021, 344,130195.

13. Xiaohui Zhu, Wen Han, Yongfei Liu, Haihui Wang, Danying Lin, Zhangcheng Fu, Yu He*, Xiaofei Yin, Chunhua Lu* and Huanghao Yang. Rational design of a prodrug to inhibit self-inflammation for cancer treatment. Nanoscale 2021, 13, 5817–5825.

14. Shuxian Cai, Ziyi Chen, Yingjie Wang, Min Wang, Junye Wu, Yuhong Tong, Lanlan Chen*, Chunhua Lu* and Huanghao Yang*. Reducing PD-L1 Expression with a Self-Assembled Nanodrug: an Alternative to PD-L1 Antibody for Enhanced Chemo-Immunotherapy. Theranostics 2021, 11, 1970-1981.

15. Yuhong Lin^#, Yuqing Huang^#, Yuling Yang, Lili Jiang, Chao Xing, Jingying Li*, Chunhua Lu* and Huanghao Yang. Functional Self-Assembled DNA Nanohydrogels for Specific Telomerase Activity Imaging and Telomerase-Activated Antitumor Gene Therapy. Anal. Chem. 2020, 92, 22, 15179-15186.

16. Yifan Jiang, Xin Xu, Xiao Fang, Shuxian Cai, Min Wang, Chao Xing, Chunhua Lu* and Huanghao Yang*. Self-Assembled mRNA-Responsive DNA Nanosphere for Bioimaging and Cancer Therapy in Drug-Resistant Cells. Anal. Chem. 2020, 92, 11779-11785.

17. Chao Xing, Ziyi Chen, Junduan Dai, Jie Zhou, Liping Wang, Kai-Long Zhang, Xiaofei Yin, Chunhua Lu* and Huanghao Yang*. Light-Controlled, Toehold-Mediated Logic Circuit for Assembly of DNA Tiles. ACS Appl. Mater. Interfaces 2020, 12, 5, 6336-6342.

18. Chao Xing, Junduan Dai, Yuqing Huang, Yuhong Lin, Kai-Long Zhang, Chunhua Lu* and Huanghao Yang*. Active Self-Assembly of Train-Shaped DNA Nanostructures via Catalytic Hairpin Assembly Reactions. Small 2019, 1901795.

19. Yuhong Lin, Lili Jiang, Yuqing Huang, Yuling Yang, Yu He, Chunhua Lu* and Huanghao Yang*. DNA-mediated reversible capture and release of circulating tumor cells with a multivalent dual-specific aptamer coating network. Chem. Commun. 2019, 55, 5387-5390.

20. Haihui Wang, Qianying Lin, Litian Yin, Yuling Yang, Yuan Qiu, Chunhua Lu* and Huanghao Yang*. Biomimetic Design of Hollow Flower-Like g-C3N4@PDA Organic Framework Nanospheres for Realizing an Efficient Photoreactivity. Small 2019, 1900011

21. Lin Zhong,^# Shuxian Cai,^# Yuqing Huang, Litian Yin, Yuling Yang, Chunhua Lu,*and Huanghao Yang*. DNA Octahedron-Based Fluorescence Nanoprobe for Dual Tumor-Related mRNAs Detection and Imaging. Anal. Chem. 2018, 90, 12059-12066.

22. Chao Xing, Yuqing Huang, Junduan Dai, Lin Zhong, Huimeng Wang, Yuhong Lin, Juan Li, Chun-Hua Lu,* and Huang-Hao Yang*. Spatial Regulation of Biomolecular Interactions with a Switchable Trident-Shaped DNA Nanoactuator. ACS Appl. Mater. Interfaces 2018, 10, 32579-32587.

23. Huimeng Wang, Lin Zhong, Yang Liu, Xin Xu, Chao Xing, Min Wang, Shu-Meng Bai, Chun-Hua Lu* and Huang-Hao Yang*. A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy. Chem. Commun. 2018, 54, 3142-3145.

24. 18. Kaimei Ke, Wen Yang, Xiaoli Xie, Rui Liu, Li-Li Wang, Wei-Wen Lin, Guoming Huang, Chun-Hua Lu*, Huang-Hao Yang*. Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window. Theranostics 2017, 7, 4763-4776.

25. Yongqiang Dong, Qian Wang, Haishan Wu, Yingmei Chen, Chun-Hua Lu*, Yuwu Chi*, Huang-Hao Yang*. Graphitic Carbon Nitride Materials: Sensing, Imaging and Therapy. Small 2016, 12, 5376-5393.

26. Chun-Hua Lu, Alessandro Cecconello, and Itamar Willner*. Recent Advances in the Synthesis and Functions of Reconfigurable Interlocked DNA Nanostructures. J. Am. Chem. Soc. 2016, 138, 5172-5185.

27. Chun-Hua Lu and Itamar Willner*. Stimuli-Responsive DNA-Functionalized Nano-/Microcontainers for Switchable and Controlled Release. Angew. Chem. Int. Ed. 2015, 54, 12212-12235.

28. Chun-Hua Lu, Xiu-Juan Qi, Alessandro Cecconello, Stefan-Sven Jester, Michael Famulok and Itamar Willner*. Switchable Reconfiguration of an Interlocked DNA Olympiadane Nanostructure. Angew. Chem. Int. Ed. 2014, 53, 7499-7503.

29. Chun-Hua Lu, Xiu-Juan Qi, Ron Orbach, Huang-Hao Yang, Iris Mironi-Harpaz, Dror Seliktar and Itamar Willner*. Switchable Catalytic Acrylamide Hydrogels Cross-Linked by Hemin/G-Quadruplexes. Nano Lett. 2013, 13, 1298-1302.

30. Chun-Hua Lu, Fuan Wang and Itamar Willner*. Zn²⁺-Ligation DNAzyme-Driven Enzymatic and Nonenzymatic Cascades for the Amplified Detection of DNA. J. Am. Chem. Soc. 2012, 134, 10651-10658.

31. Chun-Hua Lu, Juan Li, Mei-Hua Lin, Yi-Wei Wang, Huang-Hao Yang*, Xi Chen and Guo-Nan Chen. Amplified Aptamer based Assay through Catalytic Recycling of the Analyte. Angew. Chem. Int. Ed. 2010, 49, 8454 -8457.

32. Chun-Hua Lu, Huang-Hao Yang*, Chun-Ling Zhu, Xi Chen and Guo-Nan Chen. A Graphene Platform for Sensing Biomolecules. Angew. Chem. Int. Ed. 2009, 48, 4785-4787.

33. Chun-Hua Lu, Wen-Hui Zhou, Bing Han, Huang-Hao Yang*, Xi Chen and Xiao-Ru Wang*. Surface-Imprinted Core-Shell Nanoparticles for Sorbent Assays. Anal. Chem. 2007, 79, 5457-5461.

获奖情况

其他