姓    名:刘见永
性    别:

职    称:研究员(博导)
学    历:博士
职    务:
电    话:0591-22867105
专    业:有机化学、药物化学
电子邮件:liujianyong82@163.com
研究方向:有机共轭大环化合物的合成及性能研究

 

教育工作经历

2011 - 2018      福州大学化学学院                      副研究员、研究员

2008-2010      香港中文大学化学系                  博士后

2005-2008      香港中文大学化学系                  博士


 教学简介

承担本科生课程:《有机化学》《综合化学实验》《有机化学实验》

承担研究生课程:《实验室安全讲座》《有机化学研究方法与实验》

 

科研简介

 研究兴趣:

氟硼二吡咯、酞菁类抗癌光敏药物的设计与药效研究;

有机染料分子荧光探针的设计及其在细胞、活体肿瘤中的成像研究;

染料敏化太阳能电池材料的设计及其光电转换性能研究;

酞菁和氟硼二吡咯的超分子化学。


 社会兼职

中国抗癌协会光动力治疗专业委员会委员

中国化学会应用化学学科委员会卟啉与酞菁专业委员会秘书

担任Chemical Communications, Journal of Medicinal Chemistry, Green Chemistry, Chemistry A European Journal, Organic Letters, RSC Advances, ChemMedChem, Current Medicinal Chemistry等期刊的通讯审稿人。

 

科研项目

1. 国家自然科学基金:生物素介导靶向光动力治疗-化疗联用抗癌药物的合成及构效关系研究    (No.21401733)  
2. 国家自然科学基金:叶酸-酞菁共轭物抗癌光敏剂的合成及其靶向光动力活性 (No.21101028) 

3. 福建省科技厅重大项目:抗癌光敏剂福大赛因临床 2期人体药代动力学研究 (No. 2015Y0086)

4. 福建省自然科学基金:光动力治疗-化疗联用前药的合成及协同抗肿瘤活性研究 (No. 020J01440)

5. 福建省自然科学基金:Cu(I)催化“点击化学”合成靶向抗癌光敏剂 (No.2012J05021)  
6. 福州大学海外引进人才项目:功能配合物 (No.022382)  
7. 福州大学科研启动项目:靶向抗癌光敏剂的研究 (No.600366)    
8. 福州大学科技发展基金:分子靶点抗癌光敏剂 (N0.2011-XY-6)



代表性论文

1. Xu, G.; Zhang, H.-X.; Li, X.-Q.; Yang, D.-C.; Liu, J.-Y.* “Red light triggered photodynamic-chemo combination therapy using a prodrug caged by photosensitizer”, Eur. J. Med. Chem., 2021, 215, 113251. DOI: 10.1016/j.ejmech.2021.113251. 

2. Weng, X.-L.; Liu, J.-Y.* “Strategies for maximizing photothermal conversion efficiency based on organic dyes”, Drug Discov. Today, 2021. DOI: 10.1016/j.drudis.2021.03.009.

3. Song, M.; Liu, G.; Liu, Y.; Cheng, Z.; Lin, H.; Liu, J.-Y.; Wu, Z.; Xue, J.; Hong, W.; Huang, M.; Li, J.; Xu, P. “Using porphyrins as albumin-binding molecules to enhance antitumorefficacies and reduce systemic toxicities of antimicrobial peptides”, Eur. J. Med. Chem., 2021, 217, 113382. DOI: 10.1016/j.ejmech.2021.113382.

4. Cao, J.-J.; Zhang, M.-S.; Li, X.-Q.; Yang, D.-C.; Xu, G.; Liu, J.-Y.* “A glutathione-responsive photosensitizer with fluorescence resonance energy transfer characteristics for imaging-guided targeting photodynamic therapy”. Eur. J. Med. Chem., 2020, 193, 112203. DOI:10.1016/j.ejmech.2020.112203.

5. Dai, T.; Ye, F.-R; Hu, P.; Pan, X.; Su, J.; Huang, Y.; Chen, J.; Zhang, L.; Wang, H.; Huang, M.; Liu, J.-Y.; Chen, X.; Chen, Z.*, “A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system” Sci. China Mater., 2020, 64, 232-240.

6. Shi, W.-J.; Liu, J.-Y.; Lo, P.-C.; Ng, D. K.-P.*“Selective Detection of Hg2+ Ions with Boron Dipyrromethene-Based Fluorescent Probes Appended with a Bis(1,2,3-triazole)amino Receptor”, Chem. Asian.J., 2019, 14(7), 1059-1065.

7. Chen, Y.; Liu, J.; Song, M.; Jiang, L.; Liu, L; Liu, Y.; Fu, G.; Xue, J.; Liu, J.-Y.*; Huang, M.*; Li, J*. “Insights into the binding mechanism of BODIPY-based photosensitizers to human serum albumin: A combined experimental and computational study”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 203, 158–165.

8. Lin, H.; Chen, J.; Zhang, Y.; Ullab, A.; Liu, J.-Y.; Lin, F.; Jiang, L.; Huang, M*. “Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine”, J. Inorg. Biochem., 2018, 189, 192–198.

9. Zhang, F.-L.; Song, M.-R.; Yuan, G.-K.; Ye, H.-N.; Tian, Y.; Huang, M.-D.; Xue, J.-P.; Zhang, Z.-H.*; Liu, J.-Y.* “A Molecular Combo of Zinc(II) Phthalocyanine and Tamoxifen Derivative for Dual Targeting Photodynamic Therapy and Hormone Therapy”J. Med. Chem., 2017, 60, 6693-6703.

10. Liu, J.-Y.*; Hou, X.-N.; Tian, Y.; Jiang, L.*; Deng, S.; Röder, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a bis(triphenylamine)–BODIPY–C60 artificial photosynthetic system”, RSC Advances, 2016, 6, 57293-57305.

11. Liu, J.-Y.; Li, J.; Yuan, X.; Wang, W.-M.; Xue, J.-P.* “In vitro photodynamic activities of zinc(II) phthalocyaninessubstituted with pyridine moieties”, Photodiagnosis and Photodynamic Therapy, 2016, 13, 341-343.

12. Chen, J.; Ye, H.; Zhang, M.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* “Erlotinib Analogue-substituted Zinc(II) Phthalocyanines for Small Molecular Target-based Photodynamic Cancer Therapy”, Chin. J. Chem., 2016, 34, 983-988.

13. Ermilov, E. A. *; Liu, J.-Y.; Menting, R.; Huang, Y.-S.; Röder, B.;Ng, D. K. P.*“An artificial photosynthetic model based on a molecular triad of boron dipyrromethene and phthalocyanine”Phys. Chem. Chem. Phys., 2016, 18, 10964-10975.

14. Zhang, F.-L.; Huang, Q.;Liu, J.-Y.; Huang, M.-D.; Xue, J.-P.* “Molecular-Target-Based Anticancer Photosensitizer: Synthesis and in vitro Photodynamic Activity of Erlotinib–Zinc(II)Phthalocyanine Conjugates” ChemMedChem, 2015, 10(2), 312-320.

15. Ermilov, E. A.*;Schlak, M.; Steffen, R.; Liu, X.-Q.; Liu, J.-Y.;Röder, B. “Energy transfer properties of a novel boron dipyrromethene–perylenediimide donor–acceptor dyad”RSC Adv., 2015, 5, 67141-67148.

16. Zhou, X.-Q.; Meng, L.-B.; Huang, Q.; Li, J.; Zheng, K.; Zhang, F.-L.; Liu, J.-Y.; Xue, J.-P.* “Synthesis and in vitro Anticancer Activity of Zinc(II) Phthalocyanines Conjugated with Coumarin Derivatives for Dual Photodynamic and Chemotherapy” ChemMedChem, 2015, 10, 304-311.

17. Lin, J.; Zhu, C.; Liu, X.; Chen, B.; Zhang, Y.; Xue, J.;Liu, J.-Y.* “A Highly Selective and turn-on fluorescence probe for Fe3+ ion based on perylene tetracarboxylic diimide” Chin. J. Chem., 2014, 32, 1116-1120.

18. Jia, X.; Yue, F.; Chen, X.; Pan, H.-B.; Liu, W.-G.*; Liu, J.-Y.* “One-pot controlled synthesis of single-crystal a-Fe2O3 hollow nanostructure and its gas sensing properties”RSC Adv., 2014, 4, 42899-42904.

19. Chen, Z.; Xu, P.; Chen, J.; Chen, H.; Hu, P.; Chen, X.; Lin, L.; Huang, Y.; Zheng, K.; Zhou, S.; Li, R.; Chen, S.; Liu, J.-Y.; Xue, J.; Huang, M. “Zinc phthalocyanine conjugated with the amino-terminal fragment of urokinase for tumor-targeting photodynamic therapy” Acta Biomaterialia, 2014, 10(10), 4257-4268.

20. Liu, J.-Y.; Huang, Y.-S.; Menting, R.; Röder, B.; Ermilov, E. A.;Ng, D. K. P.* “A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model” Chem. Commun.2013, 49, 2998-3000.

21. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “A light-harvesting porphyrin-boron dipyrromethene conjugate”J. Porphyrins Phthalocyanines2013, 17, 831-835.

22. Menting, R.;Liu, J.-Y.;Huang,Y.-S.;Ng, D. K. P.;Röder, B.;Ermilov, E. A.* “Photoinduced energy and charge transfer in ap-phenylene-linked dyad of boron dipyrrometheneand monostyryl boron dipyrromethene”Phys. Chem. Chem. Phys.2013, 15, 6912-6919.

23. Zhang, F.-L.; Huang, Q.; Zheng, K.; Li, J.;Liu, J.-Y.*; Xue, J.-P.* “A novel strategy for targeting photodynamic therapy.Molecular combo of photodynamic agent zinc(II)phthalocyanine and small molecule target-basedanticancer drug erlotinib”Chem. Commun.2013, 49, 9570-9572.

24. Jia, X.; Yang, F.-F.; Li, J.; Liu, J.-Y.; Xue, J.-P.*“Synthesis and in Vitro Photodynamic Activity of Oligomeric EthyleneGlycol−Quinoline Substituted Zinc(II) Phthalocyanine Derivatives”J. Med. Chem. 2013, 56, 5797-5805.

25. He, H.; Liu, J.-Y.;and Ng, D. K. P.* “A Phthalocyanine-Based Fluorescent Sensor for Zn2+Ion”, J. Porphyrins Phthalocyanines2013, 17, 99-103.

26. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Ferrocene-Distyryl BODIPY Dyad and a Ferrocene-Distyryl BODIPY-C60 Triad” ChemPhysChem, 2012, 13, 2030-2036.

27. Shi, W.-J.; Liu, J.-Y.; Ng, D. K. P.* “A Highly Selective Colorimetric and Fluorescent Probe for Cu2+ and Hg2+ Ions Based on a Distyryl BODIPY with Two Bis(1,2,3-triazole)amino Receptors”Chem. Asian.J.2012,7(1), 196-200.

28. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.*; Ng, D. K. P.* “Mimicking the Photosynthetic Antenna-Reaction Center Complexes with a (Boron Dipyrromethene)3-Porphyrin-C60 Pentad”Chem. Eur.J.2011,17, 1605-1613.

29. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Distyryl BODIPY-Fullerene Dyad”Chem. Asian.J.2011,6, 174-179.

30. Liu, J.-Y.; Lo, P.-C.; Ng, D. K. P.* “Phthalocyanine-Containing Supramolecular Arrays” Struct. Bond. 2010, 135, 169-210.

31. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* “Switching the photo-induced energy and electron-transfer processes in BODIPY-phthalocyanine conjugates” Chem. Commun.2009, 45, 1517-1519.

32. Liu, J.-Y.; Lo, P.-C.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis and in vitrophotodynamic activities of di-a-substituted zinc(II) phthalocyanine derivatives” Dalton Trans.2009, 38, 4129-4135.

33. Liu, J.-Y.; Lo, P.-C.; Fong, W.-P.; Ng, D. K. P.* “Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylated zinc(II) phthalocyanines” Org. Biomol. Chem.2009, 7, 1583-1591.

34. Ermilov, E. A.*; Liu, J.-Y.; Ng, D. K. P.*; Röder, B. “Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine-boron dipyrromethene triads” Phys. Chem. Chem. Phys.2009, 11, 6430-6440.

35. Liu, J.-Y.; Yeung, H.-S.; Xu, W.; Li, X.; Ng, D. K. P.* “Highly Efficient Energy Transfer in Subphthalocyanine-BODIPY Conjugates” Org. Lett.2008, 10(23), 5421-5424.

36. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines.  Effects of the chain length on the in vitro photodynamic activities” Org. Biomol. Chem.2008, 6, 4560-4566.

37. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis, Characterization, and in vitro Photodynamic Activities of Novel Amphiphilic Zinc(II) Phthalocyanines Bearing Oxyethylene-rich Substituents” Metal Based Drugs 2008, Article ID: 284691.

38. Lo, P.-C.; Chan, C. M. H.; Liu, J.-Y.; Fong, W.-P.; Ng, D. K.-P.* “Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties” J. Med. Chem. 2007, 50(9), 2100-2107.

 

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