姓    名:李兴淑   
性    别:

男         

职    称:闽江学者特聘教授,博导
学    历:博士研究生
职    务:
电    话:
专    业:应用化学,药物化学,生物医学工程
电子邮件:xingshuli@fzu.edu.cnxingshuli@foxmail.com
研究方向:功能染料,超分子光敏剂,纳米诊疗剂


教育工作经历

2006.09-2010.06 福州大学化学化工学院,制药工程专业,学士

2010.09-2015.06 福州大学化学学院,生物化工专业,博士(导师:黄剑东研究员)

2015.10-2018.11 韩国梨花女子大学化学与纳米科学院,博士后(合作导师:Juyoung Yoon)

2018.12-2019.05 加拿大多伦多大学药学院,博士后(合作导师:Shana O. Kelley)

2019.09-2020.02 韩国梨花女子大学化学与纳米科学院,博士后(合作导师:Juyoung Yoon)

2020.05-至今 福州大学化学学院,闽江学者特聘教授
 

教学简介

主讲研究生学位课《化工数学方法》


科研简介

主要从事基于功能染料分子构建具有疾病治疗与成像检测功能的超分子光敏剂和纳米诊疗剂,研究内容涉及到应用化学、药物化学和生物医学工程等多个学科的交叉领域。迄今,以第一作者或通讯作者发表SCI论文20余篇,包括Nat. Rev. Clin. Oncol., Chem. Soc. Rev., J. Am. Chem. Soc. (2 篇), Angew. Chem. Int. Ed. (4 篇), Adv. Mater. (2 篇), Adv. Funct. Mater., ACS Nano (2 篇), Coord. Chem. Rev. (2 篇), Biomaterials (2 篇), Theranostics (2 篇), Chem. Sci. (2 篇) 等。其中9篇入选ESI高被引论文,另有1篇被评为热点文章、1篇被选为当期期刊封面文章以及1篇成为top 10%被下载文章。受邀参与Coord. Chem. Rev.两期专刊(主题:光敏剂和荧光探针)的规划与组稿。

 

社会兼职



科研项目

1. 国家自然科学基金(面上项目):酞菁纳米聚集体的调控、光动力免疫效应与抗肿瘤转移研究22078066,64万,2021.01-2024.12。

2. 闽江学者特聘教授科研启动基金,200万,2020.06-2023.05。



代表性论文

[1] M. Yang, X. Li*, J. Yoon*. Activatable supramolecular photosensitizers: advanced design strategies. Mater. Chem. Front., 2020, DOI: 10.1039/d0qm00827c.

[2] X. Li, Y. H. Jeong, N. Kwon, J. G. Park, G. Tian, H. R. Kim, J. D. Huang*, D. S. Lee*, J. Yoon*. In vivo-assembled phthalocyanine/albumin supramolecular complexes combined with a hypoxia-activated prodrug for enhanced photodynamic immunotherapy of cancer. Biomaterials, 2021, 266, 120430.

[3] B. D. Zheng, Q. X. He, X. Li*, J. Yoon*, J. D. Huang*. Phthalocyanines as contrast agents for photothermal therapy. Coord. Chem. Rev., 2021, 426, 213548.

[4] X. Li, J. F. Lovell*, J. Yoon*, X. Chen*. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat. Rev. Clin. Oncol., 2020, 17, 657-674.

[5] E. Lee, X. Li*, J. Oh, N. Kwon, G. Kim, D. Kim*, J. Yoon*. A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria. Chem. Sci., 2020, 11, 5735.

[6] X. Li, E. Y. Park, Y. Kang, N. Kwon, M. Yang, S. Lee, W. J. Kim*, C. Kim*, J. Yoon*. Supramolecular phthalocyanine assemblies for improved photoacoustic imaging and photothermal therapy. Angew. Chem. Int. Ed., 2020, 59, 8630-8634.

[7] Z. H. Yu, X. Li, F. Xu, X. L. Hu, J. Yan, N. Kwon, G. R. Chen, T. Tang, X. Dong, Y. Mai*, D. Chen*, J. Yoon*, X. P. He*, H. Tian. A supramolecular-based dual-wavelength phototherapeutic agent with broad spectrum antimicrobial activity against drug resistant bacteria. Angew. Chem. Int. Ed., 2020, 59, 3658-3664.

[8] X. Li, K. Jeong, Y. Lee, T. Guo, D. Lee, J. Park, N. Kwon, J. H. Na, S. K. Hong, S. S. Cha, J. D. Huang*, S. Choi*, S. Kim*, J. Yoon*. Water-soluble phthalocyanines selectively bind to albumin dimers: a green approach toward enhancing tumor-targeted photodynamic therapy. Theranostics, 2019, 9, 6412-6423.

[9] X. Li, H. Fan, T. Guo, H. Bai, N. Kwon, K. H. Kim, S. Yu, Y. Cho, H. Kim, K. T. Nam*, J. Yoon*, X. B. Zhang*, W. Tan. A sequential protein-responsive nanophotosensitizer complex for enhancing tumor-specific therapy. ACS Nano, 2019, 13, 6702-6710.

[10] X. Li, S. Yu, Y. Lee, T. Guo, N. Kwon, D. Lee, S. C. Yeom, Y. Cho, G. Kim, J. D. Huang*, S. Choi*, K. T. Nam*, J. Yoon*. In vivo albumin traps photosensitizer monomers from self-assembled phthalocyanine nanovesicles: A facile and switchable theranostic approach. J. Am. Chem. Soc., 2019, 141, 1366-1372.

[11] X. Li, H. Bai, Y. Yang, J. Yoon*, S. Wang*, X. Zhang*. Supramolecular antibacterial materials for combatting antibiotic resistance. Adv. Mater., 2019, 31, 1805092.

[12] X. Li, B. D. Zheng, X. H. Peng, S. Z. Li, J. W. Ying, Y. Zhao, J. D. Huang*, J. Yoon*. Phthalocyanines as medicinal photosensitizers: developments in the last five years. Coord. Chem. Rev., 2019, 379, 147-160.

[13] X. Li, C. y. Kim, J. M. Shin, D. Lee, G. Kim, H. M. Chung*, K. S. Hong*, J. Yoon*. Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy. Biomaterials, 2018, 187, 18-26.

[14] X. Li, D. Lee, J. D. Huang*, J. Yoon*. Phthalocyanine-assembled nanodots as photosensitizers for highly efficient type I photoreactions in photodynamic therapy. Angew. Chem. Int. Ed., 2018, 57, 9885-9890.

[15] X. Li*, N. Kwon, T. Guo, Z. Liu*, J. Yoon*. Innovative strategies for hypoxic-tumor photodynamic therapy. Angew. Chem. Int. Ed., 2018, 57, 11522-11531.

[16] X. Li*, S. Lee, J. Yoon*. Supramolecular photosensitizers rejuvenate photodynamic therapy. Chem. Soc. Rev., 2018, 47, 1174-1188.

[17] X. Li, X. H. Peng, B. D. Zheng, J. Tang, Y. Zhao, B. Y. Zheng, M. R. Ke, J. D. Huang*. New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates. Chem. Sci., 2018, 9, 2098-2104.

[18] X. Li, S. Yu, D. Lee, G. Kim, B. Lee, Y. Cho, B. Y. Zheng, M. R. Ke, J. D. Huang*, K. T. Nam*, X. Chen*, J. Yoon*. Facile supramolecular approach to nucleic-acid-driven activatable nanotheranostics that overcome drawbacks of photodynamic therapy. ACS Nano, 2018, 12, 681-688.

[19] X. Li, C. y. Kim, S. Lee, D. Lee, H. M. Chung, G. Kim, S. H. Heo, C. Kim*, K. S. Hong*, J. Yoon*. Nanostructured phthalocyanine assemblies with protein-driven switchable photoactivities for biophotonic imaging and therapy. J. Am. Chem. Soc., 2017, 139, 10880-10886.

[20] X. Li, J. Kim, J. Yoon*, X. Chen*. Cancer-associated, stimuli-driven, turn on theranostics for multimodality imaging and therapy. Adv. Mater., 2017, 29, 1606857.

[21] X. Li, S. Kolemen, J. Yoon*, E. U. Akkaya*. Activatable photosensitizers: agents for selective photodynamic therapy. Adv. Funct. Mater., 2017, 27, 1604053.

[22] X. Li, B. Y. Zheng, M. R. Ke, Y. Zhang, J. D. Huang*, J. Yoon*. A tumor-pH-responsive supramolecular photosensitizer for activatable photodynamic therapy with minimal in vivo skin phototoxicity. Theranostics, 2017, 7, 2746-2756.

[23] X. S. Li, M. R. Ke, M. F. Zhang, Q. Q. Tang, B. Y. Zheng, J. D. Huang*. A non-aggregated and tumour-associated macrophage-targeted photosensitiser for photodynamic therapy: a novel zinc(II) phthalocyanine containing octa-sulphonates. Chem. Commun., 2015, 51, 4704-4707.

[24] X. S. Li, M. R. Ke, W. Huang, C. H. Ye, J. D. Huang*. A pH-responsive layered double hydroxide (LDH)-phthalocyanine nanohybrid for efficient photodynamic therapy. Chem. Eur. J., 2015, 21, 3310-3317.

[25] X. S. Li, J. Guo, J. J. Zhuang, B. Y. Zheng, M. R. Ke, J. D. Huang*. Highly positive-charged zinc(II) phthalocyanine as non-aggregated and efficient antifungal photosensitizer. Bioorg. Med. Chem. Lett., 2015, 25, 2386-2389.


获奖情况

第十四届福建省自然科学优秀学术论文一等奖

Dyes and Pigments突出贡献审稿人称号

福建省药剂年会优秀论文奖


其他

课题组常年招收应用化学、药物化学、纳米材料科学、生物医学工程等相关专业的硕士、博士、科研助理、博士后,待遇优厚。有意向者请发送简历至邮箱:xingshuli@fzu.edu.cn

 

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