教育工作经历

2016.07至今        福州大学 化学学院工作

2015 - 2016         新南威尔士大学（澳大利亚）   访问学者

2013 - 2015         福州大学                                   博士后

2008 - 2013         福州大学   生物化工专业          博士

2004 - 2008         福州大学   制药工程专业          学士  

教学简介

主讲《制药过程安全与环保》、《制药技术经济》、《制药工程专业实验V》和《信息检索与应用》等

科研简介

  目前研究兴趣：  
（1）靶向抗癌光敏剂的设计、合成及性能研究；  
（2）新型抗真菌化合物的设计、合成及其新剂型的研究。

社会兼职

科研项目

 主持国家自然科学基金（青年项目）1项，校科研启动基金项目1项，福建省教育厅课题1项，福建省自然科学基金1项。

代表性论文

1、Bi-Yuan Zheng, Song-Zi Li, Bing-De Zheng, Jia-Wen Ying, Qing-Yan Hu, Xiao-Hui Peng, Xingshu Li, Mei-Rong Ke and Jian-Dong Huang. Phthalocyanine-based photosensitizers combined with anti-PD-L1 for highly efficient photodynamic immunotherapy. Dyes and Pigments 2021, 185: 108907.

2、Bi-Yuan Zheng, Lei Wang, Qing-Yan Hu, Jie Shi, Mei-Rong Ke, Jian-Dong Huang. Novel unsymmetrical silicon(IV) phthalocyanines as highly potent anticancer photosensitizers. Synthesis, characterization, and in vitro photodynamic activities. Dyes and Pigments 2020, 177: 108286.

3、Bi-Yuan Zheng, Xiao-Qing Yang, Yang Zhao, Qiao-Feng Zheng, Mei-Rong Ke, Tao Lin, Ren-Xun Chen, Kitty K.K. Ho, Naresh Kumar, Jian-Dong Huang. Synthesis and photodynamic activities of integrin-targeting silicon(IV) phthalocyanine-cRGD conjugates. European Journal of Medicinal Chemistry, 2018,155: 24-33.

4、Bi-Yuan Zheng, Mei-Rong Ke, Wen-Liang Lan, Lu Hou, Jun Guo, Dong-Hua Wan, Ling-Zhi Cheong, Jian-Dong Huang. Mono- and tetra-substituted zinc(II) phthalocyanines containing morpholinyl moieties: synthesis, antifungal photodynamic activities, and structure-activity relationships. European Journal of Medicinal Chemistry, 2016, 114:380-389.

5、Bi-Yuan Zheng, Xiao-Min Shen, Dong-Mei Zhao, Yi-Bin Cai, Mei-Rong Ke, Jian-Dong Huang. Silicon(IV) phthalocyanines substituted axially with different nucleoside moieties. Effects of nucleoside type on the photosensitizing efficiencies and in vitro photodynamic activities. Journal of Photochemistry and Photobiology B, 2016, 159:196-204.

6、Bi-Yuan Zheng, Xiong-Jie Jiang, Tao Lin, Mei-Rong Ke, Jian-Dong Huang. Novel silicon(IV) phthalocyanines containing piperidinyl moieties: Synthesis and in vitro antifungal photodynamic activities. Dyes and Pigments, 2015, 112: 311-316.

7、Bi-Yuan Zheng, Tao Lin, Huang-Hao Yang, Jian-Dong Huang. Photodynamic inactivation of Candida albicans sensitized by a series of novel axially di-substituted silicon (IV) phthalocyanines. Dyes and Pigments, 2013, 96(2): 547-553.

8、Bi-Yuan Zheng, Hong-Peng Zhang, Mei-Rong Ke, Jian-Dong Huang. Synthesis and antifungal photodynamic activities of a series of novel zinc (II) phthalocyanines substituted with piperazinyl moieties. Dyes and Pigments, 2013, 99(1): 185-191.

9、Xiao-Min Shen*, Bi-Yuan Zheng*, Xiu-Rong Huang , Lei Wang, Jian-Dong Huang. First silicon (IV) phthalocyanine-nucleoside conjugates with high photodynamic activity. Dalton Transactions, 2013, 42(29):10398-10403.（共同第一作者）

10、Qun Sun,Bi-Yuan Zheng, Yan-Hong Zhang, Jing-Jing Zhuang, Mei-Rong Ke, Jian-Dong Huang. Highly photocytotoxic silicon(IV) phthalocyanines axially modified with L-tyrosine derivatives: Effects of mode of axial substituent connection and of formulation on photodynamic activity. Dyes and Pigments 2017, 141: 521-529.

11、Dong-Hua Wan,Bi-Yuan Zheng, Mei-Rong Ke, Ji-Ying Duan,Yun-Quan Zheng, Chih-Kuang Yeh, Jian-Dong Huang. C-Phycocyanin as a tumour-associated macrophage-targeted photosensitiser and a vehicle of phthalocyanine for enhanced photodynamic therapy. Chem. Commun., 2017,53: 4112-4115.

12、Xing-Shu Li, Bi-Yuan Zheng, Mei-Rong Ke, Yong-fan Zhang, Jian-Dong Huang*, Juyoung Yoon* , A Tumor-pH-Responsive supramolecular photosensitizer for activatable photodynamic therapy that has minimal in Vivo skin phototoxicity, Theranostics, 2017, 7(10):2746-2756.

13、杨晓梅, 郑碧远, 蔡悦, 林爱兰, 沈小敏, 张汉辉, 黄剑东. 轴向核苷修饰硅酞菁与白蛋白非共价复合物的制备与光动力活性, 光谱学与光谱分析, 2015, 35(2): 457-461.

14、沈小敏, 郑碧远, 张汉辉, 黄剑东. 一种轴向核苷修饰硅酞菁的合成与光动力抗癌活性.光谱学与光谱分析, 2013, 33(10): 2731-2735.

15、李姗, 郑碧远, 郭甜, 许文龙, 黄剑东. 抗真菌的化学治疗与光动力治疗药物的研究进展.海峡药学, 2011, 23(5): 6-11. 

获奖情况

其他