姓名：林雨琦

职称：副教授

学历：博士

专业：化学生物学

电子邮件：Linyuqi@fzu.edu.cn

研究方向：生物催化不对称合成， 电-酶级联催化， 酶工程改造

教育与工作经历

2023.08 — 至今 福州大学化学学院，副教授、硕导。

2018.09 — 2023.06  中国科学院上海有机化学研究所，理学博士

2014.09 — 2018.06  福州大学化学学院，理学学士

科研简介

主要从事生物催化、电-酶级联催化、酶工程改造等研究。目前以第一作者及通讯作者在Proc. Natl. Acad. Sci. U.S.A., JACS Au., Org. Chem. Front., CCS Chem., Org. Lett.等刊物上发表SCI论文10余篇。

代表性论文

14. Bin Zhao, Ding-Bo Zeng, Xinglei He, Jing-Heng Li, Yuqi Lin* and Ke-Yin Ye*. Electrochemical Conversions of Sulfenamides into Sulfonimidoyl- and Sulfondiimidoyl Fluorides. JACS Au. 2025, 5, 2359-2367.

13. Fang-Ling Gao, Xinglei He, Bin Zhao, Yuqi Lin* and Ke-Yin Ye*. Electrochemical conversion of N-sulfinylamines to sulfonimidoyl fluorides. Chin. J. Chem. 2025, 43, 769-774.

12. Yuqi Lin*, Jiage Yu and Ke-Yin Ye*. Integrating electrocatalysis with biocatalysis for asymmetric synthesis. Org. Chem. Front. 2024, 11, 7243-7248.

11. Yuqi Lin*, Wanqing Xue, Hechen Li, Bingmei Su, Juan Lin* and Ke-Yin Ye*. Advances in Enzymatic Incorporation of Small Fluorine Modules. Eur. J. Org. Chem. 2024, 17, e202400003.

10. Cheng-Lin Ding, Hechen Li, Yi Zhong, Yuqi Lin* and Ke-Yin Ye*. Hypervalent iodine catalysis enabled iterative multi-fluorination: not just a simple alternative for the electrochemical approach. Chem. Commun. 2024, 60, 13738-13741.

9. Cheng-Lin Ding, Qiaohong Xu, Shuai Wu, Yi Zhong, Xinglei He, Yuqi Lin*, Yuanming Li* and Ke-Yin Ye*. Current-Controlled Electrochemical Approach Toward Mono- and Trifluorinated Isoindolin-1-one Derivatives. Org. Lett. 2024, 26, 1546-1551.

8. Jun-Fa Han,^# Fang-Ling Gao,^# Lin Chen, Zi-Xin He, Yuqi Lin* and Ke-Yin Ye*.  Cobalt-Catalyzed Oxytrifluoromethylation of N-Allylamides toward Trifluoromethyl-Containing Oxazolines. Asian. J. Org. Chem. 2024, 13, e202300579.

7. Ting Liu,^# Zhaojiang Shi,^# Yaofeng Yuan, Yuqi Lin* and Ke-Yin Ye*. Electrochemical Dearomative Spirocyclization of N-acyl Sulfonamides in a Continuous-flow Cell. Chin. J. Chem. 2024, 42, 980-984.

6. Yi-Min Jiang,^# Yong-Ying Lin,^# Lingyun Zhu, Yi Yu, Yuanming Li, Yuqi Lin* and Ke-Yin Ye*. A General Electrochemical Synthesis of Sulfonimidoyl Fluorides, Azides, and Acetates. CCS Chem. 2024, 6, 2021-2030.

5. Yuqi Lin, Biao Yu*, Pengfei Fang*, Jing Wang*. Inhibiting autophagy before it starts. Autophagy 2024, 20, 923-924.

4. Yuqi Lin, Qiqi Shi, Guang Yang, Fuchun Shi, Yang Zhou, Tongtong Wang, Peng Xu, Peifeng Li, Zaizhou Liu, Hanyin Sun, Zhixin Zhao, Ke Ding, Zhen Wang, Haizhong Feng*, Biao Yu*, Pengfei Fang*, Jing Wang*. A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB. Proc. Natl. Acad. Sci. U.S.A. 2023, 120, e2213670120.

3. Yuqi Lin, Jinxiang Ye, Wenting Zhang, Yu Gao, Haijun Chen*. Catalytic Oxidative Coupling Cyclization for Construction of Benzofuroindolenines under Mild Reaction Conditions. Adv. Synth. Catal. 2019, 361, 432-435.

2. Yuqi Lin, Rong Liu, Ping Zhao, Jinxiang Ye, Zheng Zheng, Jingan Huang, Yingying Zhang, Yu Gao, Haiying Chen, Suling Liu, Jia Zhou, Ceshi Chen, Haijun Chen*. Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer. Eur. J. Med. Chem. 2018, 146, 354-367.

1. Jinxiang Ye^†, Yuqi Lin^†, (co-first author) Qing Liu, Dekang Xu, Fan Wu, Bin Liu, Yu Gao, Haijun Chen*. Biomimetic Oxidative Coupling Cyclization Enabling Rapid Construction of Isochromanoindolenines. Org. Lett. 2018, 20, 5457-5460.

科研项目

福建省中青年教师教育科研项目（JAT231005），主持，2024年-2026年

福州大学科研启动基金（511311），主持，2023年

获奖情况

2025年 福建省C类高层次人才

2024年 “Wiley China Excellent Author Program”