姓    名：	叶克印
	性    别：	男
	职    称：	闽江学者特聘教授
	学    历：	博士
	职    务：
	电    话：
	专    业：	有机化学
	电子邮件：	kyye@fzu.edu.cn
	研究方向：	课题组主页 https://www.x-mol.com/groups/Ye_Keyin

 

教育工作经历

 

05/2019至今          福州大学化学学院，“闽江学者”特聘教授

 

04/2017-05/2019   博士后, 康奈尔大学 (Cornell University), 美国

                              合作导师: Song Lin教授

                              研究方向: 催化电化学合成

 

10/2014-03/2017   博士后, 明斯特大学 (Universität Münster), 德国

                              合作导师: Gerhard Erker教授

                              研究方向: 受阻路易斯酸碱对 (FLPs) 参与的小分子活化与催化

 

09/2009-07/2014   博士, 中国科学院上海有机化学研究所

                              导师: 戴立信 院士 & 游书力 研究员

                              论文: 金属铱催化的烯丙基取代反应：手性杂环的合成和催化剂设计

 

09/2005-07/2009   本科, 厦门大学 化学化工学院化学系

                              导师: 黄培强 教授 & 张洪奎 教授

                              论文: 天然产物 (+)-Preussin的合成

教学简介

主讲基础有机化学、有机结构分析等课程。

科研简介   

课题组面向国家及社会发展的重大需求，瞄准世界药物技术前沿领域，发展面向医药、农药等高端精细化学品的关键共性技术。在研究方法上，侧重于通过设计合成新型的手性过渡金属催化剂，深入研究催化反应机理，提高催化反应的效率和选择性，实现一系列具有重要药物活性分子的高效精准合成及工业化应用研究。迄今为止，共发表SCI论文50余篇（包括顶级期刊论文10篇），文章他引1500余次（包含1篇ESI高被引论文），h指数20。同时，授权中国专利4项，参与撰写两部外文图书。

1. 电化学合成

2. 不对称催化

3. 药物化学
 

社会兼职

 

国际学术期刊Chinese Chemical Letters青年编委（2021.10-）

国际学术期刊Green Synthesis & Catalysis青年编委（2020.8-）

精细化学品先进制造福建省高校工程研究中心 客座教授（2020.6-）

 

科研项目

1. 廉价过渡金属氟代络合物的制备及其催化反应研究（22171046），国家自然科学基金面上项目，2022-2025，在研，主持。

2. 电化学促进的二氧化碳不对称催化反应研究（21901041），国家自然科学基金青年项目，2020-2022，在研，主持。

3. 有机电化学合成（50012742），福建省第七批引才“百人计划”，2021-2022，在研，主持

4. 电化学合成（510841），闽江学者特聘教授计划启动基金，2019-2021，在研，主持。

5. 电化学促进的磺酰胺类化合物的绿色合成（202008）, 厦门大学固体表面物理化学重点实验室开放课题项目，2021-2022, 在研，主持。

6. 过渡金属催化的不对称去芳构化反应中的新策略研究（21272252），国家自然科学基金面上项目，2013-2016，已结题，参与。

 

代表性论文

  

2022年

1. Zhaojiang Shi, Yuanyuan Li, Nan Li, Wei-Zhen Wang, Hao-Kuan Lu, Hong Yan, Yaofeng Yuan, Jun Zhu*, and Ke-Yin Ye *, Electrochemical Migratory Cyclization of N-acylsulfonamides, Angew. Chem. Int. Ed. 2022, Accepted Article.

2. Zhaojiang Shi,^#  Nan Li,^# Wei-Zhen Wang, Hao-Kuan Lu, Yaofeng Yuan*, Zhen Li and Ke-Yin Ye*, Electrochemical 5-exo-dig aza-cyclization of 2-alkynylbenzamides toward 3-hydroxyisoindolinone derivatives, Org. Biomol. Chem. 2022, 20, 4320-4323. (^#equal contribution)

3. Yi Yu,^# Shao-Fen Wu,^# Xiao-Bin Zhu, Yaofeng Yuan*, Zhen Li and Ke-Yin Ye*, Electrochemical Sulfoxidation of Thiols and Alkyl Halides, J. Org. Chem. 2022, 87, 6942-6950. (^#equal contribution)

4. Zhaojiang Shi,^# Hao-Kuan Lu,^# Nan Li, Yaofeng Yuan*, Zhen Li and Ke-Yin Ye*, Electrochemical oxidative dearomatization of 2-arylthiophenes, Org. Chem. Front. 2022, 9, 2921-2925. (^#equal contribution)

5. Peng Guo,^# Guo-Cai Yuan,^# Liu-Hui Xu and Ke-Yin Ye*, Cobalt-catalyzed modular assembling toward multi-functionalized furan derivatives. Org. Chem. Front. 2022, 9, 1628-1633.

6. Jun-Fa Han,^# Peng Guo,^# Lin Chen (本科生), Ke-Yin Ye*, Cobalt-catalyzed Glaser-type Homocoupling Reaction. Synthesis 2022, 54, 1989-1995. (^#equal contribution, Invited Feature Article)

7. Junsong Zhong, Chenglin Ding, Hyunwoo Kim,* Terry M^cCallum,* Keyin Ye,* Alternating current electrolysis: a photoredox catalysis mimic and beyond. Green Synth. Catal. 2022, 3, 4-10.

8. 李懿伦 (本科生)、余意、袁耀锋*，叶克印*，硫-氟的邻位交叉效应，大学化学，2021, DOI: 10.3866/PKU.DXHX202110088.

9. Xiang-Gui Zhang, ^# Zi-Xin He,^# Peng Guo, ^# Zheng Chen (本科生), Ke-Yin Ye*; Cobalt-catalyzed Divergent Markovnikov and Anti-Markovnikov Hydroamination. Org. Lett. 2021, 24, 22-26. (Dedicated to Professor Pei-Qiang Huang on the occasion of his 60th birthday)

10. Yi Yu, Yi-Min Jiang, Shao-Fen Wu, Zhaojiang Shi, Jin-Nan Wu (本科生), Yaofeng Yuan* and Ke-Yin Ye*, Electrochemistry enabled selective vicinal fluorosulfenylation and fluorosulfoxidation of alkenes, Chin. Chem. Lett. 2020, 33, 2009-2014. also see: ChemRxiv, 2021, DOI: 10.33774/chemrxiv-2021-bpgxh.

2021年

11. Yi Yu, Ke-Yin Ye*, Electroreduction of Alkyl Halides to Alkyl Boronic Esters, Chin. J. Org. Chem. 2021，41, 4526-4527. (Invited Highlight)

12. Yi-Min Jiang, Yi Yu, Shao-Fen Wu, Hong Yan, Yaofeng Yuan and Ke-Yin Ye*, Electrochemical fluorosulfonylation of styrenes. Chem. Commun. 2021, 57, 11481-11484. (In 2021 Chem Commun Emerging Investigators themed collection)

13. 叶克印*、张香归、袁耀锋，利用二维核磁解析复杂有机分子的结构，大学化学，2021, 36, 2106023.

14. Lingxiang Lian, Jingyi Yin, Caixia Lin*, Ke-Yin Ye, Yaofeng Yuan*, Phosphine Oxide-Directed Palladium-Catalyzed Heck-type Functionalization of o-Carboranes. Chin. J. Org. Chem. 2021，41, 3249-3255.

15. Jun-Song Zhong, Zi-Xin Yang, Cheng-Lin Ding (本科生), Ya-Feng Huang (本科生), Yi Zhao, Hong Yan, Ke-Yin Ye*; Desulfonylative Electrocarboxylation with Carbon Dioxide. J. Org. Chem. 2021, 86, 16162-16170. (Invited contribution to the special issue: Electrochemistry in Synthetic Organic Chemistry)

16. Peng Guo,^# Jun-Fa Han,^# Guo-Cai Yuan, Lin Chen (本科生), Jia-Bin Liao, Ke-Yin Ye*; Cobalt-Catalyzed Divergent Aminofluorination and Diamination of Styrenes with N‑Fluorosulfonamides. Org. Lett. 2021, 23, 4067-4071. (^#equal contribution)

17. Jun-Song Zhong, Yi Yu, Zhaojiang Shi, Keyin Ye*; An electrochemical perspective on the roles of ligands in the merger of transition-metal catalysis and electrochemistry. Org. Chem. Front. 2021, 8, 1315-1328.

18. Jun-Song Zhong, Yi Yu, Dong-Liang Zhang (本科生), Ke-Yin Ye*; Merging cobalt catalysis and electrochemistry in organic synthesis. Chinese. Chem. Lett. 2021, 32, 963-972. (Dedicated to the 70th anniversary of Shanghai Institute of Organic Chemistry, in Chinese Chemical Letters Highlights Collection, 2021)

19. Zhaojiang Shi, Nan Li, Hao-Kuan Lu, Xiaoping Chen, Huidong Zheng, Yaofeng Yuan and Ke-Yin Ye*, Recent Advances in the Electrochemical Hydrogenation of Unsaturated Hydrocarbons. Curr. Opinion Electrochem. 2021, 28, 100713. (Invited Highlight)

20. Zixin Yang, Yi Yu, Liangchuan Lai, Ledan Zhou, Ke-Yin Ye* and Fen-Er Chen*, Carbon dioxide cycle via electrocatalysis: electrochemical carboxylation of CO₂ and decarboxylative functionalization of carboxylic acids. Green Synth. Catal. 2021, 2, 19-26.

2020年

21. Lingxiang Lian, Caixia Lin*, Yi Yu, Yaofeng Yuan and Ke-Yin Ye*, Phosphine oxide-directed palladium-catalyzed B(3)–H arylation of o-carboranes. Tetrahedron Lett. 2020，61, 152625. (Selected as the front cover)

22. Jun-Fa Han, Peng Guo, Xiang-Gui Zhang, Jia-Bin Liao (本科生), Ke-Yin Ye*; Recent advances in the cobalt-catalyzed allylic functionalization. Org. Biomol. Chem. 2020, 18, 7440-7450. (Invited Review, dedicated to Prof. Xue-Long Hou on the occasion of his 65th birthday)

23. Jin-Nan Wu (本科生), Yi Yu,* Ke-Yin Ye*; Highly Site-selective Electrooxidation Providing Facile Entries to Functionalized Aromatic Acetals. Chemical Research in Chinese Universities 2020, 36, 723-724. (Invited Highlight)

24. Xiang-Gui Zhang, Peng Guo, Jun-Fa Han, Ke-Yin Ye*; Cobalt Fluorides: Preparation, Reactivity and Applications in Catalytic Fluorination and C–F Functionalization. Chem. Commun. 2020, 56, 8515-8523. (Invited Review, in Chemical Communications Hot Articles Themed Collections)

25. Peng Guo, Yuanyuan Li, Xiang-Gui Zhang, Jun-Fa Han, Yi Yu, Jun Zhu,^* Ke-Yin Ye*; Redox Neutral Radical-Relay Cobalt Catalysis towards C-H Fluorination and Amination. Org. Lett. 2020, 22, 3601-3606. (Highlighted by CBG)

26. Yi Yu, Jun-Song Zhong, Kai Xu (本科生), Yaofeng Yuan, Ke-Yin Ye*; Recent Advances in the Electrochemical Synthesis and Functionalization of Indole Derivatives. Adv. Synth. Catal. 2020, 362, 2102-2119. (VIP, In the special issue dedicated to the 80th birthday of Prof. Bernd Giese)

27. Yi Yu,^# Peng Guo,^# Jun-Song Zhong, Yaofeng Yuan, Ke-Yin Ye*; Merging Photochemistry with Electrochemistry in Organic Synthesis. Org. Chem. Front. 2020, 7, 131-135. (^#equal contribution, Invited Review, dedicated to Professor Li-Xin Dai on the occasion of his 95th birthday, among the journal’s top 2020 content)

2019年以前

28. Ke-Yin Ye,^# Terry McCallum,^# Song Lin; Bimetallic Radical Redox-Relay Catalysis for the Isomerization of Epoxides to Allylic Alcohols. J. Am. Chem. Soc. 2019, 141, 9548. (^# equal contribution)

29. Ke-Yin Ye, Gisselle Pombar, Niankai Fu, Gregory S Sauer, Ivan Keresztes, Song Lin*; Anodically Coupled Electrolysis for the Hetero-difunctionalization of Alkenes. J. Am. Chem. Soc. 2018, 140, 2438. (Highlighted by X-MOL)

30. Ke-Yin Ye, Hu He, Wen-Bo Liu, Li-Xin Dai, Guenter Helmchen, Shu-Li You*; Iridium-Catalyzed Allylic Vinylation and Asymmetric Allylic Amination Reactions with o-Aminostyrenes. J. Am. Chem. Soc. 2011, 133, 19006. (Highlighted by Synfacts 2012, 8, 170)

31. Ke-Yin Ye, Qiang Cheng, Chun-Xiang Zhuo, Li-Xin Dai, Shu-Li You*; An Iridium(I) N-Heterocyclic Carbene Complex Catalyzes Asymmetric Intramolecular Allylic Amination Reactions. Angew. Chem., Int. Ed. 2016, 55, 8113. (Highlighted by Synfacts 2016, 12, 697)

32. Ke-Yin Ye, Gerald Kehr, Constantin G. Daniliuc, Lei Liu, Stefan Grimme, Gerhard Erker*; Coupling of Carbon Monoxide with Nitrogen Monoxide at a Frustrated Lewis Pair Template. Angew. Chem., Int. Ed. 2016, 55, 9216.

33. Ke-Yin Ye, Markus Bursch, Zheng-Wang Qu, Constantin G. Daniliuc, Stefan Grimme, Gerald Kehr, Gerhard Erker*; Reversible Formylborane/SO₂ Coupling at a Frustrated Lewis Pair Framework. Chem. Commun. 2017, 53, 633.

34. Ke-Yin Ye, Zhidong Song, Gregory S. Sauer, Johannes H. Harenberg, Niankai Fu, Song Lin*; Synthesis of Chlorotrifluoromethylated Pyrrolidines by Electrocatalytic Radical Ene-Yne Cyclization. Chem. Eur. J. 2018, 24, 12274.

35. Ke-Yin Ye, Li-Xin Dai, Shu-Li You*; Regio- and Enantioselective Synthesis of N-Allylindoles by Iridium-Catalyzed Allylic Amination/Transition-Metal-Catalyzed Cyclization Reactions. Chem. Eur. J. 2014, 20, 3040.

36. Ke-Yin Ye, Xiao Zhang, Li-Xin Dai, Shu-Li You*; Ruthenium-Catalyzed Regioselective Allylic Trifluoromethylthiolation Reaction. J. Org. Chem. 2014, 79, 12106.

37. Ke-Yin Ye, Constantin G. Daniliuc, Shunxi Dong, Gerald Kehr, Gerhard Erker*; Frustrated Lewis Pair Behavior of an Open, Noninteracting Phosphane/Borane Pair at a Rigid Organic Framework: Exploring Decisive Factors for FLP Activity. Organometallics. 2017, 36, 5003.

38. Ke-Yin Ye, Li-Xin Dai, Shu-Li You*; Enantioselective Synthesis of 2,5-Dihydrobenzo[b]azepine Derivatives via Iridium-Catalyzed Asymmetric Allylic Amination with 2-Allylanilines and Ring-Closing-Metathesis Reaction. Org. Biomol. Chem. 2012, 10, 5932.

39. Ke-Yin Ye, Li-Xin Dai, Shu-Li You*; Synthesis of 1Z,4E,6E-Triene Derivatives by Chemo- and Regioselective Iridium-Catalyzed Dienylation of ortho-Aminostyrenes with Dienyl Carbonates. Asian. J. Org. Chem. 2013, 2, 244.

40. Ke-Yin Ye, Xiaowu Wang, Constantin G. Daniliuc, Gerald Kehr, Gerhard Erker*; A Ferrocene-Based Phosphane/Borane Frustrated Lewis Pair for Asymmetric Imine Reduction. Eur. J. Inorg. Chem. 2017, 368.

41. Ke-Yin Ye, Zhuo-An Zhao, Zeng-Wei Lai, Li-Xin Dai, Shu-Li You*; Highly Regioselective Allylic Substitution Reactions Catalyzed by an Air-stable (π-Allyl)iridium Complex Derived from Dinaphthocyclooctatetraene and a Phosphoramidite Ligand. Synthesis 2013, 2109.

42. Ke-Yin Ye, Ke-Jia Wu, Guo-Tai Li, Li-Xin Dai, Shu-Li You*; Synthesis of Enantioenriched Indolopiperazinones via Iridium(I) N-Heterocyclic Carbene Complex Catalyzed Asymmetric Intramolecular Allylic Amination Reaction. Heterocycles 2017, 95, 304.

43. Xiangyu Wu, Wei Hao, Ke-Yin Ye, Bingyang Jiang, Gisselle Pombar, Zhidong, Song, Song Lin*; Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors. J. Am. Chem. Soc. 2018, 140, 14836.

44. Kai-Jiong Xiao, Jie-Min Luo, Ke-Yin Ye, Yu Wang, Pei-Qiang Huang*; Direct, One-Pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation. Angew. Chem., Int. Ed. 2010, 49, 3037. (Highlighted by Synfacts 2010, 7, 822)

45. Qing-Feng Wu, Wen-Bo Liu, Chun-Xiang Zhuo, Zi-Qiang Rong, Ke-Yin Ye, Shu-Li You*; Iridium-Catalyzed Intramolecular Asymmetric Allylic Dearomatization of Phenols. Angew. Chem., Int. Ed. 2011, 50, 4455. (Highlighted by Synfacts 2011, 8, 854)

46. Wu Li, Chao Liu, Heng Zhang, Ke-Yin Ye, Guanghui Zhang, Wangzheng Zhang, Zhengli Duan, Shu-Li You*, Aiwen Lei*; Palladium-Catalyzed Oxidative C-H/N-H Carbonylationfor the Synthesis of β-lactams. Angew. Chem., Int. Ed. 2014, 53, 2443. (Highlighted by Synfacts 2014, 10, 360)

47. Hu He, Ke-Yin Ye, Qing-Feng Wu, Li-Xin Dai, Shu-Li You*; Iridium-Catalyzed Asymmetric Allylic Etherification and Ring-Closing-Metathesis Reaction for Enantioselective Synthesis of Chromene and 2,5-Dihydrobenzo[b]oxepine Derivatives. Adv. Synth. Catal. 2012, 354, 1084.

48. Kai-Jiong Xiao, Yu Wang, Ke-Yin Ye, Pei-Qiang Huang*; Versatile One-Pot Reductive Alkylation of Lactams/Amides via Amide Activation: Application to the Concise Syntheses of Bioactive Alkaloids (-)-Bgugaine, (-)-Coniine, (+)-Preussin, and (-)-Cassine. Chem. Eur. J. 2012, 16, 12792.

49. Thomas Őzgün, Ke-Yin Ye, Constantin G. Daniliuc, Birgit Wibbeling, Lei Liu, Stefan Grimme, Gerald Kehr, Gerhard Erker*; Why Does the Intramolecular Trimethylene-Bridged Frustrated Lewis Pair Mes₂PCH₂CH₂CH₂B(C₆F₅)₂ Not Activate Dihydrogen? Chem. Eur. J. 2016, 22, 5988.

50. Zeng-Wei Lai, Rong-Fei Yang, Ke-Yin Ye, Hongbin Sun, Shu-Li You*; Synthesis of 1,1’- bis(trifluoromethyl)phosphine-oxazoline ferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates. Beilstein J. Org. Chem. 2014, 10, 1261.

 

获奖情况  

2021    Chem Commun Emerging Investigator

2021    入选福建省第七批“百人计划”

2020    Thieme Chemistry Journals Award（德国）

2019    福建省“闽江学者”特聘教授

2014    中国科学院三好学生

2012    刘铸晋优秀博士生奖学金

2010    中国科学院三好学生

2009    厦门大学优秀毕业生

 

其他

 

图书章节

1. Yi-Min Jiang, Yi Yu, Zhaojiang Shi, Yi-Lun Li, Hong Yan, Ke-Yin Ye, , in Sustainable & Functional Redox Chemistry, Shinsuke Inagi Ed, Royal Society of Chemistry, England 2022, pp 154-174.

2. De-Wei Gao, Jun Zheng, Ke-Yin Ye, Chao Zheng, Shu-Li You, in Asymmetric Functionalization of C-H Bonds, Shu-Li You Ed. Royal Society of Chemistry, England 2015, pp 141-213.

发明专利

1. 叶克印，施兆江，李楠；一种苯并[e] [1,4,3]恶噻嗪-1,1-二氧化物衍生物的制备方法（专利申请号：202111382488.5，申请日期: 2021-11-20）

2. 叶克印，施兆江，卢浩宽；一种螺环噻吩磺酰胺类化合物的合成方法（专利申请号：202111383423.2，申请日期: 2021-11-20）

3. 叶克印，余意，蒋一民；一种烯烃邻位氟磺化、氟亚砜化和氟磺酰化衍生物（中国专利号：ZL 202110582315.1，申请日期: 2021-11-20）

4. 游书力，叶克印，吴可嘉；金属铱络合物、单晶、苯并吲哚类化合物及合成方法和应用(中国专利号: ZL201510305993.8, 申请日期: 2015-06-04).

5. 游书力，赖增伟，叶克印；一种1，1’-二茂铁全氟烷基磷氮配体、其制备方法及应用(中国专利号: ZL201410065244.8, 申请日期: 2014-02-25).

6. 游书力，叶克印，赵卓安；含有二萘基[1,2-b;5,6-b’]环辛四烯和手性膦氮骨架的π-烯丙基铱络合物、合成方法以及应用 (中国专利号: ZL201310196809.1, 申请日期: 2013-05-23).